Evidence of IQ-modulated association between ZNF804A gene polymorphism and cognitive function in schizophrenia patients

ZNF804A gene polymorphism rs1344706 has been suggested as the most compelling case of a candidate gene for schizophrenia by a genome-wide association study and several replication studies. The current study of 570 schizophrenia patients and 448 controls again found significantly different genotype frequencies of rs1344706 between patients and controls. More important, we found that this association was modulated by IQ, with a stronger association among individuals with relatively high IQ, which replicated results of Walters et al, 2010. We further examined whether this IQ-modulated association also existed between the SNP and the intermediate phenotypes (working memory and executive functions) of schizophrenia. Data were available from an N-back task (366 patients and 414 controls) and the attention network task (361 patients and 416 controls). We found that the SNP and IQ had significant interaction effects on the intermediate phenotypes for patients, but not for controls. The disease risk allele was associated with poorer cognitive function in patients with high IQ, but better cognitive function in patients with low IQ. Together, these results indicated that IQ may modulate the role of rs1344706 in the etiology of both schizophrenia and its cognitive impairments, and pointed to the necessity of considering general cognitive function as indexed by IQ in the future studies of genetic bases of schizophrenia.     

胼胝体切开术治疗儿童药物难治性癫(癎)

目的 探讨胼胝体切开术治疗无法行局灶性切除的儿童药物难治性癫(癎)的安全性及有效性.方法 回顾性分析113例儿童药物难治性癫(癎)病人的临床资料,均行胼胝体切开术.结果 术后发作完全消失77例(68.1％),发作减少90％以上21例(18.6％),其中失张力性发作病人术后发作完全消失和发作减少90％以上者分别占94.1％和5.9％,而全身强直性发作病人为8.3％和75.0％.术后出现短暂的主动性语言减少3例,并在术后6-8d内恢复.随访113例,时间12个月～5年,病人精神发育状态均有不同程度的改善,无发作加重病例.结论 胼胝体切开术是治疗儿童药物难治性癫(癎)的一种安全有效的方法,特别是对失张力性发作和全身强直性发作效果更佳.     

Diagnostic Value of 64-Slice Dual-Source CT Coronary Angiography in Patients with Atrial Fibrillation: Comparison with Invasive Coronary Angiography

Objective

We wanted to evaluate the image quality and diagnostic value of 64-slice dual-source computed tomography (DSCT) coronary angiography in patients with atrial fibrillation (Afib).

Materials and Methods

The coronary arteries of 22 Afib patients seen on DSCT were classified into 15 segments and the imaging quality (excellent, good, moderate and poor) and significant stenoses (≥ 50%) were evaluated by two radiologists who were blinded to the conventional coronary angiography (CAG) results. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting important coronary artery stenosis were calculated. McNemar test was used to determine any significant difference between DSCT and CAG, and Cohen''s Kappa statistics were calculated for the intermodality and interobserver agreement.

Results

The mean heart rate was 89 ± 8.3 bpm (range: 80-118 bpm). A range from 250 msec to 300 msec within the RR interval was the optimal reconstruction interval for the patients with Afib. The respective overall sensitivity, specificity, PPV and NPV values were 74%, 97%, 81% and 96% for reader 1 and 72%, 98%, 85% and 96% for reader 2. No significant difference between DSCT and CAG was found for detecting a significant stenosis (reader 1, p = 1.0; reader 2, p = 0.727). Cohen''s Kappa statistics demonstrated good intermodality and interobserver agreement.

Conclusion

64-slice DSCT coronary angiography provides good image quality in patients with atrial fibrillation without the need for controlling the heart rate. DSCT can be used for ruling out significant stenosis in patients with atrial fibrillation with its high NPV for detecting in important stenosis.     

螺旋CT测量在胸腰段椎弓根螺钉置入术中的应用

目的 评估CT测量胸腰段椎弓根螺钉置入术中的应用价值.方法 测量22例胸腰段(T11～L2)椎弓根理想螺钉的长度、进钉间距、最小横径、外偏角,观察椎弓根后缘中点与相应横突根部和关节突的下缘的关系.结果 T11～L2理想椎弓根螺钉的长度分别为(41.43±4.04) mm、(42.28±4.90) mm、(49.52±4.98) mm、(50.74±4.67) mm;直径分别为(7.03±1.41) mm、(7.1±1.47) mm、(6.12±1.62) mm、(6.31±1.34) mm;进钉间距分别为(30.10±2.44) mm、(31.5±2.60) mm、(35.8±3.00) mm、(37.15±3.16) mm;外偏角分别为4.40°±2.23°、4.44°±1.65°、10.02°±2.30°、10.48°±2.60°.T11椎弓根拟进钉点位于横突根部上缘与关节突中垂线的交点处,T12位于横突根部中上1/3,关节突中垂线偏外处的交点,L1,2位于横突根部中点,关节突外侧缘.结论 进行胸腰段椎弓根螺钉固定术时应根据不同节段椎弓根形态特点,选择相应的螺钉直径、长度、进钉部位及方向.     

Awareness and management of pulmonary embolism among physicians in China: a nationwide cross-sectional study

Journal of Thrombosis and Thrombolysis - Pulmonary embolism (PE) is a leading cause of cardiovascular mortality. We intended to evaluate the awareness and management status of PE among Chinese...     

Interhospital transfer on intravenous thrombolysis in patients with acute ischemic stroke in three chinese municipal stroke centers

Journal of Thrombosis and Thrombolysis - We included acute ischemic stroke (AIS) patients who received recombinant tissue plasminogen activator (rt-PA) at three stroke centers via either...     

排粪造影在功能性出口梗阻诊断中的临床意义

目的探讨排粪造影在诊断与治疗功能性出口梗阻性便秘中的应用。方法对186例排便障碍者进行排粪造影检查与治疗。结果 7例X线无异常,179例有异常X线表现。其中直肠前突113例,直肠黏膜脱垂、内套叠92例,会阴下降64例,盆底痉挛综合征11例,耻骨直肠肌综合征7例,内脏下垂7例,乙状结肠疝3例。其中多种异常表现并存69例。结论排粪造影对功能性出口梗阻性便秘的诊断与治疗具有重要价值。     

直肠癌患者造瘘术后的综合护理干预

目的探讨综合护理干预在直肠癌患者造瘘术后的临床价值。方法 2007年1月至2011年1月我院共收治的64例直肠癌患者随机分为对照组(32例)和观察组(32例),2组患者均按其具体病情接受相应的外科手术、内科化疗和常规护理,观察组在此基础上实行全程个体化的综合护理干预,而对照组仅给以传统的支持性护理干预。结果观察组的患者的平均住院天数、平均医疗费用、护理满意程度、术后并发症、心理改善状态、患者生活质量等方面均明显优于对照组,P<0.05,差异有统计学意义。结论综合护理干预可有效利用医疗资源、提高护理质量、提升患者满意度,值得推广应用。