40所军队医院病种病例分型质量评价结果分析

应用病例分型质量费用监控管理软件和ＳＡＳ６．１２统计软件包,对４０所军队医院５０万份病例样本资料进行深入分析,结果显示：病例分型组合数据稳定,分析结果合理。     

试析大型综合医院在社区医疗服务中的作用

根据国家城市卫生服务体系改革的原则及对基层医院和大医院的功能定位,分析大型综合医院在社区医疗服务中的作用。指出大型综合医院应加强与城市基层医院的联系,建立全科医生培训基地,为社区医疗服务输送适用人才,建立切实可行的转诊制度,成为社区医疗服务的坚强后盾,提高社区医疗服务的质量和水平,促进社区医疗服务的发展。     

Detection of bilateral and symmetrical anomalies in technetium-99m-HMPAO brain SPECT studies.

The detection of bilateral and symmetrical regional cerebral blood flow (rCBF) abnormalities requires knowledge of the antero-posterior rCBF distribution in normal subjects of all age groups. These data are very difficult to obtain in children for ethical reasons and in older subjects because of the necessity of recruiting a large number of healthy volunteers from each age group. Therefore, to obtain normal values of antero-posterior rCBF distribution, we have retrospectively selected a group of patients with a low probability of having cerebral lesions, whose 99mTc-HMPAO brain SPECT studies were analyzed semiquantitatively. Cerebellum/mean cerebral cortex index when compared to young adults was higher in the neonatal period, slightly lower between 2 mo and 15 yr, and more or less identical after 15 yr. Cortico/occipital indexes exhibit considerable changes during the first year of life due to important differences in maturation timing of cerebral cortical areas. After 1 yr, all cerebral cortical areas approximately displayed a parallel evolution. A slight increase in fronto/occipital and temporo/occipital indexes was, however, still observed during childhood, while in elderly subjects there was a trend towards a decrease in all cortico/occipital indexes (particularly in prefrontal and motor areas). Changes that occurred after 1 yr were, however, usually smaller than interindividual variation. Despite the large range of "normal" values, the antero-posterior analysis could be useful in various neurologic disorders, because it allows detection of symmetrical rCBF anomalies undiagnosed by the right-left analysis.     

Uptake of the daunorubicin-DNA complex in cultured fibroblasts

Summary The uptake and fate of the daunorubicin-DNA complex have been studied in cultured rat embryo fibroblasts. ¹²⁵I-DNA was digested by the cells and appeared as low molecular weight fragments in the incubation medium. Subcellular fractionation of fibroblasts, previously incubated with the complex, showed that daunorubicin was localized to nuclei and lysosomes. At a high incubation concentration (17.5 M), the accumulation of the free drug exceeded that of the complex. However, at a lower concentration (1.75 M), the accumulation of the complex was as high as that of the free drug.The results are consistent with an uptake of the complex into cultured rat embryo fibroblasts by endocytosis. However, it cannot be excluded that the complex partly dissociates in the incubation medium, and that daunorubicin and DNA thereafter enter the cells separately.     

AT1受体阻滞剂和β受体阻滞剂联合治疗充血性心力衰竭

目的探讨β受体阻滞剂、AT1受体阻滞剂联合应用对CHF的治疗作用,并与血管紧张素II转换酶抑制剂(ACEI)与β受体阻滞剂合用作比较。方法对103例非瓣膜性充血性心力衰竭分组,分别给予缬沙坦加美托洛尔和培哚普利加美托洛尔治疗3个月以上,并观察有关临床指标、1年内再住院次数。结果两组治疗后的心功能、心胸比例、左心室舒张末内径、左室射血分数无明显差别,P均>0.05;但均较治疗前明显改善,P<0.05;两组1年内再住院次数也相似,P>0.05。结论AT1受体阻滞剂和β受体阻滞剂联合应用对CHF有较好的近期治疗作用,与ACEI和β受体阻滞剂合用相当。     

冠状动脉MSCT成像技术探讨

目的探讨回顾性心电门控技术在MSCT冠状动脉成像中的应用。方法15例患者做MSCT冠状动脉成像检查,采用回顾性心电门控和心脏分段重建算法,选择0.5s螺旋扫描。在9个R-Rinterval上进行冠状动脉CT图像重建。结果15例患者的230个冠状动脉节段(内径>2mm)中,213个节段(91%)在70%R-Rinterval上显示最好,15(6.4)、9(3.8%)和3(1.3%)个节段分别在80%、40%和50%R-Rinterval上显示最好。结论冠状动脉通常在心动周期R波后70%R-Rinterval上显示最好。     

神阙穴敷贴对原发性骨质疏松症骨钙素的影响

目的　观察神阙穴贴补血益精透皮贴对原发性骨质疏松症骨钙素 (BGP)的影响。方法　选择原发性骨质疏松症患者130名 ,分神阙穴贴药组 (补血益精穴位透皮贴剂 )、西药组 (羟乙磷酸钠片 )、中药组 (补血益精药丸 )、空白对照组。结果和结论　穴位敷贴组能显著提高骨钙素 (7.69± 1.65 )。穴位敷贴组与中药组 (7.82± 0 .99)和西药对照组 (7.13± 0 .89)对原发性骨质疏松症的骨钙素调整作用基本一致 (P>0 .0 5 )。     

葛根素注射液与输液配伍的稳定性考察

目的　用正交法考察葛根素与 5 %葡萄糖注射液、0 9%氯化钠注射液、葡萄糖氯化钠注射液输液配伍后的稳定性。方法　用正交设计法 ,以葛根素的稳定性为考察指标 ,以浓度、温度、时间、输液种类为可变因素 ,选用L9(34)表进行实验 ,用紫外分光光度法测定其含量。结果　浓度、温度、时间、输液种类对葛根素的稳定性未产生显著性差异。结论　在低温 (4±1℃ )、常温 (17± 1℃ )、高温 (37± 1℃ )下 ,葛根素注射液与各输液均可配伍使用。     

高效液相色谱法测定奥硝唑栓的含量

目的　建立HPLC法测定奥硝唑栓中奥硝唑含量的方法。方法　以HypersilODS 2 50mm× 4mm为分析柱 ,甲醇 水 (34∶66)为流动相 ,检测波长为 31 2nm。结果　线性范围为 1～ 9μg·ml- 1 ,r=0 9978;平均回收率为 1 0 2 8% ,RSD为 1 98%。结论　本法简便、快捷、灵敏 ,可用于该制剂的质量检验