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131.
B. B. Aleksandrov M. S. Gavrilov R. Z. Dautova R. Kh. Niyazov V. D. Sviridov N. D. Chkanikova B. Ya. Syropyatov V. S. Shklyaev Yu. V. Shklyaev 《Pharmaceutical Chemistry Journal》1992,26(1):57-58
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 26, No. 1, pp. 44–45, January, 1992. 相似文献
132.
Purified murein from Thiobacillus neapolitanus was poorly digested by lysozyme. It's sensitivity to the enzyme greatly increased after N-acetylation. The murein was found to contain 30 to 35% glucosamine residues lacking N-acetyl groups. It also contained phosphomuramic acid. Further modifications included amidation of diaminopimelic acid in the peptide side chains and a low alanine content. None of these modifications were found in the murein of another sulphur bacterium, Thiobacillus versutus. 相似文献
133.
E Zuskin Z Zagar E N Schachter J Mustajbegovic J Kern 《British journal of industrial medicine》1992,49(6):435-440
A group of 59 workers (41 men and 18 women) employed in swine confinement areas was studied to assess the presence of acute and chronic respiratory symptoms and the prevalence of abnormalities in ventilatory function. A control group of 46 (31 men and 15 women) unexposed workers was studied for the prevalence of chronic respiratory symptoms. For both male and female swine confinement workers complaints of chronic cough, dyspnoea, and chest tightness were significantly more frequent than among control workers. Male workers also complained more of chronic phlegm. Male swine confinement workers who were smokers had significantly higher prevalences of chronic cough, chronic phlegm, and chronic bronchitis than male non-smoking swine confinement workers. The frequency of acute symptoms associated with the workshift was high among the swine confinement workers with more than half of the workers complaining of cough and dyspnoea associated with work. Significant acute across shift reductions in lung function occurred in swine confinement workers, being largest for FEF25. All Monday preshift ventilatory capacity measurements in male confinement workers were significantly lower than predicted values; FVC and FEV1 were found to be lower than predicted values for women. The data indicate that exposure in swine confinement buildings is associated with the development of acute and chronic respiratory symptoms and impairment of lung function. Smoking appears to aggravate these changes. 相似文献
134.
This exploratory study examined the family environment of ten families, each with a physically disabled adolescent and at least one non-disabled adolescent. Family members completed the Moos Family Environment Scale (FES) and discussed with the interviewer their experiences as a family. Blind and independent ratings on the FES by social workers involved in the study provided a comparison with the families' self ratings. Family ratings on the FES gave no indication of distress, but showed slightly higher than average emphasis on cohesion and achievement orientation. Social work ratings, in contrast, indicated elevated levels of conflict, achievement orientation, and control. In this report, no attempt is made to generalize these specific findings to all families with disabled adolescents. Rather, results are interpreted, in the light of findings in the recent literature, to underscore the need for better designed research and to alert professionals to the danger of imposing the prevalent dysfunctional view upon families with disabled children and adolescents. 相似文献
135.
L W Brady C Miyamoto D V Woo M Rackover J Emrich H Bender S Dadparvar Z Steplewski H Koprowski P Black 《International journal of radiation oncology, biology, physics》1992,22(1):225-230
Twenty-five patients with primary presentation of malignant astrocytoma, astrocytoma with anaplastic foci, and glioblastoma multiforme were treated with surgical resection and definitive radiation therapy followed by intravenous or intra-arterial administration of Iodine-125 labeled monoclonal antibody-425, which binds specifically to human epidermal growth factor receptor. The patients presented with primary untreated disease, positive contrast enhanced computed tomography scans of the brain, and compatible clinical symptoms. In this Phase II clinical trial, the patients had surgical debulking or biopsy followed by definitively administered external beam radiation therapy and one or multiple doses (35 to 90 mCi per infusion) of radiolabeled antibody. The total cumulative doses ranged from 40 to 224 mCi. The administrations of the radiolabeled antibody were performed in most cases 4-6 weeks following completion of the primary surgery and radiation therapy. Ten patients had astrocytoma with anaplastic foci and 15 had glioblastoma multiforme. No significant life-threatening toxicities were observed during this trial. At 1 year 60% of the patients with astrocytoma with anaplastic foci or glioblastoma multiforme are alive. The median survival for both groups was 15.6 months. 相似文献
136.
Z. S. Meharwal N. Trehan V. M. Kohli V. K. Sharma R. R. Kasliwal A. Mishra V. Kohli A. Jayant 《Indian Journal of Thoracic and Cardiovascular Surgery》1992,8(2):88-91
Between November 1988 and February 1992, 416 patients required coronary endarterectomy for diffuse coronary artery disease.
This constitutes 16.19 per cent of all patients who underwent coronary artery bypass grafting during the same period. A total
of 528 endarterectomies were performed. Four-hundred and twenty-two endarterectomies were performed on right coronary system
and 106 endarterectomies were performed on left coronary system. One-hundred and twelve (26.92%) patients required more than
one endarterectomies.
The hospital mortality was 2.16 percent. 3.37 per cent of patients had perioperative infarction. Intraaortic balloon pump
was required in 1.92 per cent of patients. 5.77 per cent of the patients had significant arrhythmias. The patients have been
followed up for a mean period of 27 months. One-hundred and forty patients were evaluated by exercise multigated radionuclide
angiogram. One-hundred and thirty-four (95.71%) patients showed increase in ejection fraction as compared to preoperative
value. Six (4.29%) patients did not show any significant change while eight (5.71%) patients had fall in ejection fraction.
Postoperative coronary angiogram was done in 44 patients at a mean of 10 months. 89.59 per cent of grafts to the endarterectomised
vessels and 91.67% of grafts to nonendarterectomised vessel were patent. The difference between the two groups was not statistically
significant. 相似文献
137.
Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex. 总被引:9,自引:0,他引:9
C Cepeda Z Radisavljevic W Peacock M S Levine N A Buchwald 《Synapse (New York, N.Y.)》1992,11(4):330-341
The responses of human neocortical neurons to iontophoretic application of excitatory amino acids and their modulation by dopamine (DA) were studied in vitro. Brain slices were obtained from children undergoing surgery for intractable epilepsy. Application of N-methyl-D-aspartate (NMDA) to the slices induced slow depolarizations accompanied by decreased input conductances and sustained action potentials in cortical neurons. Glutamate produced rapid depolarizations and firing with few changes in input conductances. Quisqualate also induced depolarization and firing, but input conductances increased during the rising phase of the membrane depolarization. Iontophoretic application of DA alone produced no change in membrane potential or input conductance. However, when DA was applied in conjunction with the excitatory amino acids, it produced contrasting effects. With either bath application of DA or when iontophoresis of DA preceded application of NMDA, the amplitude of the membrane depolarizations and the number of action potentials were increased, whereas the latency of these responses decreased. In contrast, DA decreased the amplitude of the depolarizations and the number of action potentials evoked by glutamate or quisqualate. The fact that DA affects responses to NMDA and glutamate or quisqualate in opposite directions is of considerable importance to the understanding of cellular mechanisms of neuromodulation and the role of DA in cognitive processing and in epilepsy. 相似文献
138.
139.
Z Radisavljevic 《The American journal of the medical sciences》1991,302(5):284-286
Oxygen consumption of the rabbit femoral artery after hemorrhagic shock was studied. Hemorrhagic shock was initiated and maintained at 60 mm Hg of systolic blood pressure for 2 hours. A significant reduction in femoral artery oxygen consumption was observed after hemorrhagic shock (1.64 +/- 0.14 microliter/g/hr) when compared to oxygen consumption in the normal condition (2.52 +/- 0.22 microliter/g/hr). Application of the beta-agonist isoproterenol significantly increased oxygen consumption in the isolated femoral artery after hemorrhagic shock (2.66 +/- 0.20 microliter/g/hr), but did not exceed the normal values recorded without stimulation. Also, isoproterenol significantly increased oxygen consumption in the femoral artery of nonhemorrhagic condition (4.84 +/- 0.42 microliter/g/hr). The increase in oxygen consumption conditioned by isoproterenol was significantly lower after hemorrhagic shock compared with values in the nonhemorrhagic state. The data suggest that oxygen consumption is regulated by beta-adrenergic receptors, and the phenomenon of diminished oxygen consumption after hemorrhagic shock probably occurs because of changes in beta-adrenergic receptors, causing the appearance of change in the mechanism of oxygen consumption. 相似文献
140.