桂枝汤对体温双向调节作用机理探讨——对发热及低体温大鼠下丘脑PGE_2含量及COX活性的影响

目的 :研究桂枝汤对体温双向调节作用与下丘脑PGE2 含量及COX活性的关系。方法 :采用放免法对下丘脑中PGE2 含量及COX活性进行同步检测。结果 :在酵母诱导发热大鼠中 ,桂枝汤可使下丘脑中PGE2 含量明显降低 (P <0 .0 5) ,而在安痛定诱导的低体温大鼠中 ,它可使PGE2 含量明显增高 (P <0 .0 5)。在两种模型中 ,桂枝汤对下丘脑细胞中COX活性的影响均不明显 (P >0 .0 5)。结论 :桂枝汤对体温的双向调节作用可能部分是通过影响PGE2 含量来实现的 ,但PGE2 含量增减不依赖于下丘脑细胞中COX活性的变化。     

益气养阴清热解毒法对EB病毒感染者中医体质证候的影响

目的:观察益气养阴清热解毒法对EB病毒感染者中医体质证候的影响。方法:对EB病毒感染者44例行随机对照试验。治疗组服用益气养阴清热解毒方药,连续服3个月;对照组未服任何药物,3个月后复查。比较两组观察前后体质证候平均积分及EBV-VCA/IgA滴度的变化。结果:治疗组的虚弱体质证候平均积分从治疗前2.54±2.11,降为治疗后1.19±1.29,差异有统计学意义(P<0.05);而其它体质证候平均积分在治疗前后差异无统计学意义(P>0.05)。对照组观察前后各体质证候平均积分差异无统计学意义(P>0.05)。治疗组治愈率58.62%,有效率20.69%,总有效率79.31%,对照组治愈率13.33%,有效率6.67%,总有效率20.00%(P<0.01)。结论:益气养阴清热解毒法能改善EB病毒感染者的虚弱体质证候,降低EB病毒活性。     

四瓣技术在改良结膜囊泪囊鼻腔吻合术中的应用

目的:探讨四瓣技术在改良结膜囊泪囊鼻腔吻合术中应用的安全性及有效性。方法:回顾性临床研究。选取2017-09/2020-06在我院就诊的泪道疾病患者28例28眼作为研究对象,均行结膜囊泪囊鼻腔吻合术。术后随访6～12mo,观察患者手术效果、满意度及术后并发症情况。结果:本组患者术后荧光素钠染料排泄试验阳性率为96%(27/28),手术成功率为96%(27/28),其中治愈率为68%(19/28),好转率为28%(8/28),无效率为4%(1/28),患者总体满意度为93%(26/28)。术后并发症包括眼部异物感(28眼)、球结膜充血(11眼)、鼻腔结膜囊渗血(8眼)及泪道引流管脱出(1眼)。结论:四瓣技术用于改良结膜囊泪囊鼻腔吻合术手术成功率高,并发症少,安全有效。     

Anti-tumor pharmacology of natural products targeting mitosis

Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis. Targeting mitosis is an effective method for cancer treatment. This review summarizes several natural products with anti-tumor effects related to mitosis, focusing on targeting microtubulin, inducing DNA damage, and modulating mitosis-associated kinases. Furthermore, the main disadvantages of several typical compounds, including drug resistance, toxicity to non-tumor tissues, and poor aqueous solubility and pharmacokinetic properties, are also discussed, together with strategies to address them. Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.     

个性化综合护理对胎膜早破患者不良情绪及新生儿结局的影响

目的 探讨个性化综合护理对胎膜早破患者焦虑、抑郁情绪及新生儿结局的影响。方法 本研究选取河南省某医院2020年3月—2021年4月收治的胎膜早破患者340例作为研究对象,按照随机数字表法分为对照组和观察组,各170例。对照组患者给予常规护理,观察组患者在对照组的基础上予以个性化综合护理。比较2组患者护理前及出院时焦虑自评表(SAS)及抑郁自评表(SDS)评分;观察记录2组患者护理后的分娩方式、产后的并发症发生情况;观察并记录2组新生儿的不良结局。结果 护理前,2组患者SAS及SDS评分比较,差异无统计学意义(P>0.05)。出院时,2组患者SAS及SDS评分均低于护理前,且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组患者自然分娩率为81.18%,高于对照组的59.41%,差异有统计学意义(P<0.05)。2组患者阴道助产率、剖宫产率比较,差异无统计学意义(P>0.05)。对照组患者并发症发生率为10.58%,高于观察组的2.36%,差异有统计学意义(P<0.05)。观察组新生儿不良结局发生率为18.23%,低于对照组的35.89%,差异有统...     

早期他汀类药物治疗对小动脉闭塞性脑梗死的效果分析及对预后的影响

目的：探究早期他汀类药物治疗对小动脉闭塞性脑梗死(SAO)的效果分析及对预后的影响。方法：选取2017年6月～2021年12月于我院治疗的80例SAO患者作为研究对象。对照组在发病1w内采用瑞舒伐他汀口服,观察组在发病24h之内采用瑞舒伐他汀口服。比较两组患者的血脂水平、神经功能、预后情况。结果：治疗后,两组患者LDL-C、TG、TC水平均低于治疗前,且观察组LDL-C、TG、TC水平低于对照组;两组患者NIHSS评分低于治疗前,且观察组低于对照组;两组患者ADL评分高于治疗前,且观察组高于对照组。结论：早期采用他汀类药物治疗,能够有效的改善SAO患者的血脂水平以及神经功能缺损的状况,还能够提高患者预后质量。     

MATLAB在医学影像物理学实验数据处理中的应用

分析MATLAB在医学院校影像物理实验教学中的应用,指出了MATLAB在医学基础实验教学中推广的意义和可行性,根据作者在医学影像物理实验教学活动中使用MATLAB的经验,提出了实验数据的MATLAB处理方法。     

Association between Excessive Dietary Branched-Chain Amino Acids Intake and Hypertension Risk in Chinese Population

The dietary intake of branched-chain amino acids (BCAAs) has been reported to be associated with both elevated blood pressure (BP) and hypertension risk, while published findings were inconsistent, and the causality has never been well disclosed. We performed this prospective study aiming to find out the relationship between dietary BCAAs intake and hypertension risk in the Chinese population. A total of 8491 participants (40,285 person-years) were selected. The levels of dietary BCAAs intake were estimated using the 24-h Food Frequency Questionnaire. Associations of both BP values and hypertension risk with per standard deviation increase of BCAAs were estimated using linear and COX regression analysis, respectively. The hazard ratios and 95% confidence interval were given. Restricted cubic spline analysis (RCS) was used to estimate the nonlinearity. Both systolic and diastolic BP values at the end points of follow-up were positively associated with dietary BCAAs intake. Positive associations between BCAAs intake and hypertension risk were shown in both men and women. By performing a RCS analysis, the nonlinear relationship between BCAAs intake and hypertension was shown. As the intake levels of Ile, Leu, and Val, respectively, exceeded 2.49 g/day, 4.91 g/day, and 2.88 g/day in men (2.16 g/day, 3.84 g/day, and 2.56 g/day in women), the hypertension risk increased. Our findings could provide some concrete evidence in the primary prevention of hypertension based on dietary interventions.