Research trends of prostatitis over past 20 years: A bibliometric analysis

In the past two decades, thousands of documents in the field of prostatitis have been published. This bibliometric analysis aimed to assess the characteristics, hotspots and frontiers trend of global scientific output on prostatitis. With the trend of moderate growth, altogether 2,423 papers were reviewed. The leading role of the United States in global prostatitis research was obvious, while China had developed rapidly in recent years. Queen's University and JOURNAL OF UROLOGY were the most prolific affiliation and journal respectively. Nickel, J. C made the greatest contribution to the field of prostatitis. Five hotspots have been confirmed: (a) male infertility associated with prostatitis and the molecular mechanisms; (b) diagnosis and treatment of prostatitis; (c) inflammation, pain and bladder irritation symptoms; (d) relationship between chronic prostatitis/chronic pelvic pain syndrome, benign prostatic hyperplasia and prostate cancer; (e) epidemiology, complications of prostatitis and improvement of acupuncture. This bibliometric analysis reveals that the international cooperation was becoming more and more close. Hotspot analysis shows that the molecular mechanism of prostatitis will be a hotspot in the future, mainly focussing on inflammatory immunity and oxidative stress.     

The anterior versus posterior approach for the treatment of ossification of the posterior longitudinal ligament in the cervical spine: A systematic review and meta-analysis

Study Design: Systematic review and meta-analysis.Objective: To compare the effectiveness and safety between anterior and posterior approach, and determine the best surgical methods for the treatment of ossification of the posterior longitudinal ligament (OPLL) in the cervical spine.Methods: We searched the Cochrane Library, PubMed, CNKI and Wanfang Med Data databases from January 2007 to March 2018. Japanese Orthopaedic Association (JOA) scores, cervical lordosis, functional recovery rates, excellent and good outcomes of the surgical approaches, and complication and reoperation rates were analyzed. RevMan 5.3 was utilized for data analysis.Results: Eleven studies were included in the meta-analysis. By comparing the anterior and posterior approaches for the treatment of OPLL in the cervical spine, statistically significant differences were found in the preoperative initial JOA, the postoperative final JOA scores, functional recovery rates, complication rates, excellent and good outcomes of the surgical approaches and reoperation rates. However, no statistically significant difference in the occurrence of the preoperative and postoperative cervical lordosis was noted.Conclusion: The anterior approach is superior to the posterior approach in terms of the postoperative final JOA score, functional recovery rate, and clinical outcomes. Although the complication and reoperation rates of the anterior approach are higher than those of the posterior approach. We recommend the anterior approach for the treatment of OPLL when patients with occupying ratio ≥ 60%. In addition, high-quality studies with long-term follow-up and large sample size are also needed.     

腹腔镜右半结肠癌切除术后消化道重建的研究现状及前景

腹腔镜右半结肠癌切除术后腹腔内吻合正逐渐成为结直肠手术领域中的热点。研究者发现:腹腔内吻合与腹腔外吻合比较,前者在促进病人术后恢复,降低术后并发症发生率等方面有潜在优势。且腹腔内吻合较腹腔外吻合病人术后胃肠功能恢复更快、术后疼痛评分更低。但对于腹腔内吻合的并发症发生率,尤其是重要指标吻合口漏的比较,尚缺乏足够证据。而手术技术不统一、吻合口漏定义不明确是目前研究的主要困难。多项高质量的前瞻性随机对照试验目前正在进行中,对于腹腔镜右半结肠癌切除术的客观评价仍需要更高级别的循证医学证据验证。笔者综合分析国内外研究进展,系统阐述腹腔镜右半结肠癌切除术后消化道重建的研究现状及前景,旨在为我国结直肠外科临床研究探索新方向。     

Chronic Effects of Bromate on Sexual Reproduction of Freshwater Rotifer Brachionus calyciflorus

The effects of potassium bromate (KBrO₃), sodium bromate (NaBrO₃), and potassium bromide (KBr) on the sexual reproduction of the rotifer Brachionus calyciflorus were studied by 2-d population growth, 4-d sexual reproduction, and 7-d resting egg production tests. The results showed that low concentrations of bromate promote 2-d and 4-d rotifer population growth, while high concentrations limit it. Bromate stress significantly affected parameters of rotifer sexual reproduction, including the ratio of mictic to amictic females, the mictic rate of rotifers, and the fertilization rate of mictic females. KBrO₃ at 0.001, 0.01, 1, and 10 mg/L, NaBrO₃ at 1 and 10 mg/L, and KBr at 100 and 200 mg/L significantly increased resting egg production, while KBrO₃ at 100 and 200 mg/L, and NaBrO₃ at 200 mg/L significantly decreased it. Resting egg production appears to provide a sensitive endpoint in evaluating the effect of bromate on rotifer sexual reproduction.

     

An Environmental Dilemma for China During the COVID-19 Pandemic: The Explosion of Disposable Plastic Wastes

Plastic pollution control has been on top of the political agenda in China. In January 2020, China announced a phased ban on the production and usage of various types of single-use plastics as a solution to environmental pollution problems. However, the outbreak of COVID-19 seems to be a new obstacle to the ban on single-use plastic products. To basically satisfied the daily necessities and contain the spread of SARS-CoV-2 under the background of the regular epidemic prevention and control in China, online ordering, contactless delivery and wearing mask have become an important and feasible way of daily life. However, the unrestrained use of disposable plastic bags, lunch boxes and masks within the nationwide quarantine leads to hundreds of millions of plastics wastes every day. The potential environmental pollution caused by the use of disposable plastic products during the pandemic should arouse social concern. The Chinese government should manage environmental protection in parallel with anti-pandemic endeavors as the situation of the pandemic evolves.

     

刺五加对肺纤维化BALF中IL－6抑制作用的研究

在用石棉灌肺制成大鼠支气管肺纤维化模型基础上，应用刺五加注射液进行体内实验治疗。测定了治疗及非治疗组大鼠支气管肺泡灌洗液中单个核细胞自分泌白细胞介素６（ＩＬ－６）水平，经统计学处理两组差异显著（Ｐ＜０．０１）。说明了刺五加对ＩＬ－６的分泌有抑制作用。可能对细胞因子网络紊乱有调节作用，为临床应用刺五加治疗肺纤维化提供了实验依据。     

原发性肝癌患者手术前后血清SICAM-1、VEGF水平检测的临床意义

目的:分析了31例原发性肝癌患者手术前后血清SICAM-1、VEGF水平的变化。方法:采用双抗 体夹心法测定了31例原发性肝癌患者手术前后血清SICAM-1、VEGF含量,并与35名正常人作比较。结果: 手术前血清SICAM-1、VEGF水平非常显著地高于正常人组(P<0.01),手术后6个月,复发者SICAM-1、 VEGF水平持续异常,未复发者SICAM-1、VEGF水平恢复正常。结论:观察原发性肝癌患者血清SICAM-1 和VEGF水平的变化与原发性肝癌患者的病情和预后密切相关。     

微电极记录技术在立体定向手术治疗帕金森病中的应用

目的：提高立体定向手术的定位精确度。方法：32例帕金森患者均采用CT定位。通过微电极描述和记录苍白球腹后内侧部（Gpi)及丘脑腹外侧核（Vim)的电生理信号。从而pi和Vim核的电生理靶点。结果：电生理靶点坐标与原始CT靶点坐标的更换率为64%。总有效率为90%,无永久性并发症,结论：微电极记录技术的应用提高了手术治疗帕金森病的效果。降低了手术并发症。     

EGb对MPP^＋诱导的PC12细胞凋亡的影响

目的 观察EGb对MPP^ 诱导的PC12细胞凋亡的细胞。方法 MPP^ 诱导PC12细胞凋亡,AO／EB染色,荧光显微镜下观察凋亡细胞。结果 EGb50、100μg/ml在6h、12h、24h可抑制细胞凋亡,而EGb25μg/ml则无效。结论 EGb在6h、12h、24h时呈剂量依赖性降低细胞凋亡率,提示EGb有可能通过抑制DA能神经元凋亡而相对增加DA含量。     

一种新的鼠大脑局部缺血模型

目的 制成鼠大脑局部缺血模型。方法 采用左侧颈动脉离心端插管,灌注一定压力和流量的生理盐水。结果 ①美蓝染色显示大脑左侧大部分区域被染蓝,除皮层着色较浅外,其余部位着色较深。②体感诱发电位在灌注后30min时,其幅度超过灌注前20％。结论 染色说明大脑左侧为缺血区,体感诱发电位幅度的增高,表明大脑处于兴奋性损伤状态。证实了此方法制成的大脑局部缺血可靠,且省时省力简便易行。