全文获取类型
收费全文 | 977490篇 |
免费 | 71434篇 |
国内免费 | 1726篇 |
专业分类
耳鼻咽喉 | 13736篇 |
儿科学 | 25279篇 |
妇产科学 | 24128篇 |
基础医学 | 140406篇 |
口腔科学 | 28962篇 |
临床医学 | 84950篇 |
内科学 | 192545篇 |
皮肤病学 | 20854篇 |
神经病学 | 76237篇 |
特种医学 | 39479篇 |
外国民族医学 | 79篇 |
外科学 | 157508篇 |
综合类 | 18474篇 |
现状与发展 | 2篇 |
一般理论 | 250篇 |
预防医学 | 64765篇 |
眼科学 | 22577篇 |
药学 | 76595篇 |
3篇 | |
中国医学 | 2580篇 |
肿瘤学 | 61241篇 |
出版年
2019年 | 7017篇 |
2018年 | 10198篇 |
2017年 | 7996篇 |
2016年 | 9205篇 |
2015年 | 10718篇 |
2014年 | 14205篇 |
2013年 | 20084篇 |
2012年 | 27742篇 |
2011年 | 28593篇 |
2010年 | 16985篇 |
2009年 | 16047篇 |
2008年 | 27117篇 |
2007年 | 28161篇 |
2006年 | 28701篇 |
2005年 | 27545篇 |
2004年 | 26346篇 |
2003年 | 25195篇 |
2002年 | 24615篇 |
2001年 | 55495篇 |
2000年 | 57286篇 |
1999年 | 47624篇 |
1998年 | 11061篇 |
1997年 | 9767篇 |
1996年 | 9844篇 |
1995年 | 9173篇 |
1994年 | 8486篇 |
1993年 | 7815篇 |
1992年 | 35979篇 |
1991年 | 34435篇 |
1990年 | 33185篇 |
1989年 | 32363篇 |
1988年 | 29490篇 |
1987年 | 28728篇 |
1986年 | 26723篇 |
1985年 | 25565篇 |
1984年 | 18168篇 |
1983年 | 15419篇 |
1982年 | 8016篇 |
1979年 | 16032篇 |
1978年 | 10817篇 |
1977年 | 9213篇 |
1976年 | 8011篇 |
1975年 | 8755篇 |
1974年 | 10637篇 |
1973年 | 10043篇 |
1972年 | 9514篇 |
1971年 | 8956篇 |
1970年 | 8551篇 |
1969年 | 8045篇 |
1968年 | 7303篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
72.
Dominique Trudel Luminita-Mihaela Avarvarei Michèle Orain Stéphane Turcotte Marie Plante Jean Grégoire Reinhild Kappelhoff David P. Labbé Dimcho Bachvarov Bernard Têtu Christopher M. Overall Isabelle Bairati 《Pathology, research and practice》2019,215(6):152369
Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. A targeted DNA microarray known as the CLIP-CHIP microarray was used to identify potential prognostic factors in ten high-grade serous ovarian cancer women who had early recurrence (<1.6 years) or late/no recurrence after first line surgery and chemotherapy. In women with early recurrence, we identified seven upregulated genes (TMPRSS4, MASP1/3, SPC18, PSMB1, IGFBP2, CFI – encoding Complement Factor I – and MMP9) and one down-regulated gene (ADAM-10). Using immunohistochemistry, we evaluated the prognostic effect of these 8 candidate genes in an independent cohort of 112 high-grade serous ovarian cancer women. Outcomes were progression, defined according to CA-125 criteria, and death. Multivariate Cox proportional hazard regression models were done to estimate the associations between each protein and each outcome. High ADAM-10 expression (intensity of 2–3) was associated with a lower risk of progression (adjusted hazard ratio (HR): 0.51; 95% confidence interval (CI): 0.29-0.87). High complement factor I expression (intensity 2–3) was associated with a higher risk of progression (adjusted HR: 2.30, 95% CI: 1.17–4.53) and death (adjusted HR: 3.42; 95% CI: 1.72–6.79). Overall, we identified the prognostic value of two proteases, ADAM-10 and complement factor I, for high-grade serous ovarian cancer which could have clinical significance. 相似文献
73.
74.
Accuracy and Precision of Acetabular Component Placement With Imageless Navigation in Obese Patients
Leonard T. Buller Alexander S. McLawhorn Jose A. Romero Peter K. Sculco David J. Mayman 《The Journal of arthroplasty》2019,34(4):693-699
Background
Obesity is a risk factor for acetabular component malposition when total hip arthroplasty is performed with manual techniques. The utility of imageless navigation in obese patients remains unknown. This study compared the accuracy and precision of imageless navigation for component orientation between obese and nonobese patients.Methods
A total of 459 total hip arthroplasties performed for osteoarthritis using imageless navigation were reviewed from a single surgeon’s institutional review board–approved database. Einzel-Bild-Roentgen Analyse determined component orientation on 6-week postoperative anteroposterior radiographs. Mean orientation error (accuracy) and precision were compared between obese (body mass index ≥ 30 kg/m2) and nonobese patients. Regression analysis evaluated the influence of obesity on component position.Results
The difference in mean inclination and anteversion between obese and nonobese groups was 1.1° (43.0° ± 3.5°; range, 35.8°-57.8° vs 41.9° ± 4.4°; range, 33.0°-57.1° and 24.9° ± 6.3°; range, 14.2°-44.3° vs 23.8° ± 6.6°; range, 7.0°-38.6°, respectively). Inclination precision was better for nonobese patients. No difference in inclination accuracy or anteversion accuracy or precision was detected between groups. And 83% of components were placed within the target range. There was no relationship between obesity (dichotomized) and component placement outside the target ranges for inclination, anteversion, or both. As a continuous variable, increased body mass index correlated with higher odds of inclination outside the target zone (odds ratio, 1.06; P = .001).Conclusion
Using imageless navigation, inclination orientation was less precise for obese patients, but the observed difference is likely not clinically relevant. Accurate superficial registration of landmarks in obese patients is achievable, and the use of imageless navigation similarly improves acetabular component positioning in obese and nonobese patients.Level of Evidence
Therapeutic Level IV. 相似文献75.
Yeon Seok Lee June Hyunkyung Lee Jae Eun Choi Joo Young Kim Tae Young Han 《Pediatric dermatology》2021,38(1):290-291
Erythema induratum of Bazin (EIB) is a form of tuberculid resulting from hypersensitivity to tuberculosis antigen. EIB occurs most commonly in middle‐aged women and is not typically seen in children. Here, we present a rare case of EIB, presenting as a chronic nodular panniculitis, in a 10‐year‐old Korean boy. 相似文献
76.
Die Anaesthesiologie - Eine junge Patientin erleidet während der Anlage einer axillären Plexusblockade einen generalisierten Krampfanfall. Die Mechanismen, im Wesentlichen die vermutlich... 相似文献
77.
78.
79.
80.
No national epidemiological investigations have been conducted recently regarding facial lacerations. The study was performed using the data of 3,634,229 people during the 5-year period from 2014 to 2018 archived by the National Health Information Database (NHID) of the Health Insurance Review and Assessment Service. Preschool and children under 10 years old accounted for about one-third of patients. Facial lacerations were concentrated in the “T-shaped” area, which comprised forehead, nose, lips, and the perioral area. The male to female ratio for all study subjects was 2.16:1. Age and gender are significantly related with each other (P < .001). Mean hospital stays decreased, and numbers of outpatient department visits per patient were highest for hospitals and lowest for health agencies. Over the study period, hospital costs per patient in tertiary and general hospitals increased gradually. Preschool and school-aged children are vulnerable to trauma. Male patients outnumbered female patients by a factor of more than 2. The “T-shaped’” area around forehead is vulnerable to injury. Total cost of medical care benefits per patient in tertiary hospitals was about 7 times on average than in health agencies. Regarding functional, behavioral, and aesthetic outcomes, more attention should be paid to epidemiologic data and hospital costs for facial lacerations. 相似文献