海上训练与跳伞训练军训伤的流行病学调查

目的　研究空军的跳伞训练和海军的海上训练期间军训伤的流行病学特征 ,制定初步的预防措施 .方法　采用就诊登记和回顾性调查的方法调查了军训伤的发生情况 .结果　空军某部新兵军训伤的发生率为 16 .3% ,海军某部新兵为18.7% ,海军老兵为 5 .5 % .空军新兵和海军新兵的发生率无显著性差异 ,海军新兵和老兵之间的发生率有显著性差异 (P<0 .0 1) .海军新兵的发生高峰为开训后第 2个月 ,海军老兵的发生高峰为开训后第 1个月 ,空军新兵开训后第 2个月发生率较低 ,其余月份均维持较高水平 .海军的受伤部位以小腿和踝关节为主 ,分别占 42 .9%和 17.9% ;空军的受伤部位以踝关节和腰部为主 ,分别占 2 6 .9%和 2 3.9% .海军和空军均以急性创伤性损伤为主要类型 ,且均以关节扭伤为主要伤型 .结论　不同于基础训练的训练内容 ,军训伤的发生情况亦不同 .根据特殊训练的特殊性 ,要制定不同的预防措施     

电生理学检查对慢性酒精中毒性周围神经病的早期诊断价值

目的：通过对慢性酒精中毒患者做电生理学检查,以及早发现无自觉症状期的周围神经损害;方法：对６４例慢性酒精中毒患者行常规肌电图检查与神经传导速度测定;结果：发现在慢性酒精中毒性周围神经病无临床自觉症状时,肌电图与神经传导速度均可出现异常改变;结论：提示肌电图与神经传导速度可作为早期诊断慢性酒精中毒性周围神经病的有效诊断方法。     

地塞米松诱导幼龄大鼠胸腺细胞凋亡模型

目的：建立一个比较实用且成型时间短的地塞米松诱导大鼠胸腺细胞凋亡模型。方法：给幼龄大鼠（４周￣５周）腹腔注射地塞米松（０．０２ｇ／ｋｇ）采用形态学（光镜和电镜）、ＤＮＡ琼脂糖凝胶电泳、流式细胞光度分析等方法研究３、６、９、１５、２４ｈ等不同注射时间胸腺细胞凋亡变化。结果：在１５ｈ内,地塞米松诱导的大鼠胸腺细胞凋亡百分率随时间延长,凋亡发生率从６．２％逐渐增至５８．５％,注射地塞米松１５ｈ,在光镜和     

老年糖尿病患者骨质疏松及骨折发生率分析

目的：探讨２型糖尿病患者骨密度改变及骨折发生率。方法：逆向随机选取住院骨折病人３８０例,测定骨密度改变,同时测定其血Ｃａ,Ｐ,ＡＫＰ,ＧＬＵ,ＢＧＰ浓度,并统计其中糖尿病的发生率及测定值对比情况。结果;骨折病人中的糖尿病患者机率为６．３２％,骨折病人的骨密度改变在糖尿病组和非糖尿病组病人中有显著差异,和本区普查结果无显著差异。结论：糖尿病病人的骨折发生率和非糖尿病患者及无明显差异,但骨密度改变有明     

手掌部浅血管神经层与屈肌支持带关系的观测

目的：为腕管松解术及掌中间隙引流术提供解剖学基础。方法：１８例（男１２、女６）３６侧成人固定上肢标本上对手掌部屈肌支持带、正中神经、尺神经在胱掌部分支点和掌浅弓最高点与屈肌支撑带下缘的距离以及足动脉终末支与正中神经间距观察。结果：正中神经掌部分支点距屈肌支持下缘９±３ｍｍ。尺神经掌部分支点距屈肌支持带下缘５±２ｍｍ。正中神经于与尺动脉终末间距为１０±２ｍｍ。结论：在手掌部裳托肌腱与第三指蹼尺侧缘     

四物汤对红细胞免疫及骨髓干细胞增殖能力的影响

用四物汤对辐射损伤小鼠进行治疗.结果表明:电离辐射对小鼠红细胞免疫功能及骨髓干细胞增殖能力有明显的抑制作用,应用四物汤治疗后红细胞免疫功能得到恢复,说明四物汤有较明显的增强红细胞免疫功能的作用.由骨髓干细胞增殖实验中可看出四物汤可使受照小鼠的骨髓干细胞增殖能力恢复正常.该研究为四物汤治疗辐射损伤引起的红细胞免疫功能及造血功能低下提供了实验依据.     

IDO1 高表达与肺鳞癌临床分期及不良预后相关

目的 探讨不同分期肺鳞癌组织中 IDO1 的表达情况及与预后的关系。 方法 纳入河北医科大学 附属医院邢台市人民医院胸外科自 2017 年 1 月至 2019 年 1 月开展手术根治的肺鳞癌患者, 留取患者术中 癌组织标本, 用免疫组织化学染色法检测 IDO1 的表达情况, 并对患者进行术后随访。 结果 肺鳞癌组织 中有 IDO1 蛋白表达, 且临床Ⅱ ~ Ⅲ期阳性细胞数显著高于Ⅰ期。 截止随访结束时, 30 例患者中 28 例存 活, 2 例死亡, 疾病稳定 22 例 (73. 3 % ), 疾病进展 8 例 (26. 7 % )。 IDO1 高表达组和低表达组的无进展 生存期 (PFS) 分别为 26 个月和 40 个月, 差异具有统计学意义 (P< 0. 05); 高临床分期和低临床分期 PFS 分别为 33 个月和 40 个月, 差异具有统计学意义 (P< 0. 05)。 结论 IDO1 在肺鳞癌中表达量与临床分期有 关, 临床分期越高表达量越高, 患者预后也越差; IDO1 能指导临床分期和预后。     

An efficient synthesis of 3-(E)-hydroxypropenyl cephem derivatives, key intermediates for 3-(E)-ammoniopropenylcephalosporin antibiotics

An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylcephem derivatives, key intermediates for the synthesis of 3-(E)-propenylcephalosporins was achievedvia Stille coupling reaction of 3-trifloxycephem with 3-(E)-tributylstannylallylic alcohol.     

Repeated Independent Exposures to Domoic Acid Do Not Enhance Symptomatic Toxicity in Outbred or Seizure-Sensitive Inbred Mice

Domoic acid (DA) is an environmental neurotoxin to humans. Thiswork examines whether repeated exposure to subsymptomatic orsymptomatic nonlethal doses of domoic acid leads to enhancedsymptomatic toxicity in ICR outbred and DBA inbred strains oflaboratory mice. A multiple independent exposure paradigm wasdesigned in which doses were administered intraperito neallyevery other day for 7 days to achieve four separate exposuresto domoic acid. We first examined the effect of repeated exposureon serum clearance of domoic acid. Serum domoic acid levelsdid not differ following a single or repeated exposure. We nextexamined the effect of repeated exposure on symptomatic toxicity.The mean toxicity scores did not show a significant differencebetween single and repeated exposures of either subsymptomatic(0.5 mg/ kg) or symptomatic sublethal (2.0 mg/kg) doses of domoicacid. We then examined the effects of repeated domoic acid exposureon a second strain of mouse. DBA mice were chosen based upontheir sensitivity to kainic acid-induced seizures; however,the ICR mice were more sensitive to low-dose domoic acid toxicity,particularly in terms of onset and duration of stereotypic scratchingbehavior. Our results indicate that both strains of mice havecomparable concentration-dependent toxic responses to domoicacid; however, differences exist in the magnitude of the responseand in specific symptoms. The mean toxicity scores did not showa significant difference when a single exposure (1.0 and 2.0mg/kg domoic acid) and repeated exposure of the same dose werecom pared in the DBA mice. This study provides no evidence thatshort-term repeated exposure to domoic acid in laboratory micealters domoic acid clearance from the serum, or leads to a moresensitive or a greater neurotoxic response.     

Inhibitory effects of plant extracts on adjuvant-induced arthritis

Twenty seven plant extracts were selected on the basis of ancient literature search for rheumatoid arthritis or similar syndrome. Methanol extract of each plant was prepared and administered orally to rats everyday at a dose of 200 mg/kg/day. Experimental arthritis was induced by subplantar injection of heat-killedMycobacterium butyricum to right hind paw of rats. This treatment provoked swelling of the treated paw in two phases, acute primary swelling and secondary arthritic swelling. An inhibition of secondary swelling was considered to be antiarthritic activity. Several plant methanol extracts such asAkebia quinata (caulis),Ephedra sinica (herba) andSophorae subprostrata (radix) were found to show significant inhibitory activity against secondary swelling at the dose tested. Our results strongly suggested an antiarthritic potential of these plant extracts.