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51.
功能性消化不良(FD)是常见的胃肠道疾病,消化不良症状量表和生活质量量表是目前评价FD干预措施疗效较为客观的手段。本文就消化不良症状量表和生活质量量表评价FD的研究进展作一综述。 相似文献
52.
Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. 总被引:16,自引:1,他引:16 下载免费PDF全文
J C Clark S E Wert C J Bachurski M T Stahlman B R Stripp T E Weaver J A Whitsett 《Proceedings of the National Academy of Sciences of the United States of America》1995,92(17):7794-7798
Surfactant protein B (SP-B) is an 8.7-kDa, hydrophobic protein that enhances the spreading and stability of surfactant phospholipids in the alveolus. To further assess the role of SP-B in lung function, the SP-B gene was disrupted by homologous recombination in murine mouse embryonic stem cells. Mice with a single mutated SP-B allele (+/-) were unaffected, whereas homozygous SP-B -/- offspring died of respiratory failure immediately after birth. Lungs of SP-B -/- mice developed normally but remained atelectatic in spite of postnatal respiratory efforts. SP-B protein and mRNA were undetectable and tubular myelin figures were lacking in SP-B -/- mice. Type II cells of SP-B -/- mice contained no fully formed lamellar bodies. While the abundance of SP-A and SP-C mRNAs was not altered, an aberrant form of pro-SP-C, 8.5 kDa, was detected, and fully processed SP-C peptide was markedly decreased in lung homogenates of SP-B -/- mice. Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth. 相似文献
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Jinlun Chen Xingyu Wang Jin Li Haitao Zhang Yijin Li Peng Deng Wenjun Feng Xinyu Qi Pengcheng Ye Jiahao Li Jianchun Zeng Yirong Zeng Jie Li Shuihua Xie 《Orthopaedic Surgery》2022,14(12):3378
ObjectiveThe treatment of chronic osteomyelitis (COM) is extremely challenging for physicians and patients. It is of great significance to explore the research status, development trend and future research hotspots in the field of COM to promote the development of this field. This study is aimed to explore the global research status of COM and predict its future research hotspots based on bibliometric and visualized analysis.MethodsWeb of Science core collection database was used to search the related literature of COM from 1994 to 2020. All data were imported into Microsoft Excel 2019 for collation. Additionally, the literature quality of countries, authors, journals, and institutions is evaluated. The VOS viewer software was used for conducting co‐analysis, co‐citation analysis, and keyword co‐occurrence analysis of literature to analyze the global status and predict the future hotspots of the COM field.ResultsA total of 726 articles were retrieved in this study. The number of global publications shows a trend of wave growth, but the increase is not significant. It is expected that the number of COM articles will remain at more than 50 per year in the next decade. The COM literature published in the United States (Publications = 160, H index = 37, average citations per item = 28.63) is of the highest quality. Girschick HJ (Publications = 16, H index = 14, average citations per item = 52.25) is the most contributed scholar in the field of COM. UNIV IOWA (Publications = 15, H index = 11, average citations per item = 57.27) and UNIV WURZBURG (Publications = 18, H index = 15, average citations per item = 47.5) are influential institutions in the field of COM. The results of co‐occurrence analysis show that the field of COM can be roughly divided into the following five modules: COM surgical research, COM basic research, COM diagnosis‐related research, chronic recurrent multifocal osteomyelitis (CRMO)‐related research, risk factors of COM. Risk factors of COM are the module with the highest concentration of hot words.ConclusionCOM‐related research will continue to develop further in the next decade. The diagnosis research and risk factors of COM are the most popular research modules in recent years. Some controversial or troubled issues including the efficacy of perforator flap and fascia flap covering soft tissue, searching exclusive detection methods for the diagnosis of COM and bisphosphonates and biological agents in the treatment of CRMO may lead to the development of the COM field. 相似文献
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Absence of Lamellar Bodies with Accumulation of Dense Bodies Characterizes a Novel Form of Congenital Surfactant Defect 总被引:1,自引:0,他引:1
A. Francine Tryka Susan E. Wert Jon E. Mazursky Robert W. Arrington Lawrence M. Nogee 《Pediatric and developmental pathology》2000,3(4):335-345
Two female sibling full-term newborns developed respiratory distress shortly after birth, which progressed to respiratory failure. Tracheal lavage demonstrated presence of surfactant protein A (SP-A), but little surfactant protein B (SP-B), without aberrant surfactant protein C (SP-C). On a lung biopsy performed in both infants, prominent type II pneumocyte hyperplasia was evident. Through ultrastructural examination an absence of normally formed lamellar bodies was determined, with numerous irregular electron dense bodies within the type II pneumocytes. These electron dense bodies could also be identified in the alveolar spaces and alveolar macrophages. No alveolar tubular myelin was present. Abnormally high immunoreactivity for surfactant proteins SP-A, proSP-B, SP-B, and proSP-C was demonstrated by light microscopy. Presence of incompletely processed immunopositive proSP-B, but not proSP-C was observed in the alveolar lumina. No mutations in either the SP-B or SP-C gene were identified by sequence analysis of amplified cDNA. We conclude that these siblings exhibit an inherited surfactant deficiency characterized by abnormal accumulations of surfactant proteins within the pneumocytes. This abnormal accumulation may be due to a primary secretory defect, a defect in surfactant phospholipids, or an abnormal interaction between the phospholipids and surfactant proteins. Received November 17, 1998; accepted August 19, 1999. 相似文献
56.
Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice. 总被引:4,自引:2,他引:4 下载免费PDF全文
T R Korfhagen R J Swantz S E Wert J M McCarty C B Kerlakian S W Glasser J A Whitsett 《The Journal of clinical investigation》1994,93(4):1691-1699
Increased production of EGF or TGF-alpha by the respiratory epithelial cells has been associated with the pathogenesis of various forms of lung injury. Growth factors and cytokines are thought to act locally, via paracrine and autocrine mechanisms, to stimulate cell proliferation and matrix deposition by interstitial lung cells resulting in pulmonary fibrosis. To test whether TGF-alpha mediates pulmonary fibrotic responses, we have generated transgenic mice expressing human TGF-alpha under control of regulatory regions of the human surfactant protein C (SP-C) gene. Human TGF-alpha mRNA was expressed in pulmonary epithelial cells in the lungs of the transgenic mice. Adult mice bearing the SP-C-TGF-alpha transgene developed severe pulmonary fibrosis. Fibrotic lesions were observed in peribronchial, peribronchiolar, and perivascular regions, as well as subjacent to pleural surfaces. Lesions consisted of fibrous tissue that included groups of epithelial cells expressing endogenous SP-C mRNA, consistent with their identification as distal respiratory epithelial cells. Peripheral fibrotic regions consisted of thickened pleura associated with extensive collagen deposition. Alveolar architecture was disrupted in the transgenic mice with loss of alveoli in the lung parenchyma. Pulmonary epithelial cell expression of TGF-alpha in transgenic mice disrupts alveolar morphogenesis and produces fibrotic lesions mediated by paracrine signaling between respiratory epithelial and interstitial cells of the lung. 相似文献
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本文介绍了4只活猕猴头颈肌损伤的一系列生物力学冲击性能实验结果,它包括颈肌拉伸强度、应力与应变,旋转加速度等,并建立了颈肌的生物力学模型。头颈肌损伤的生物力学特性是设计头颈部的保护装备的依据,同时这些知识对了解头颈肌损伤机制及临床损伤处理也是十分有益的。 相似文献
59.
本文报道利福喷丁正常人药物动力学研究结果,健康志愿者10人单剂口服利福喷丁粉剂及胶囊600mg后的体内过程均符合血管外一室模型,其血药峰浓度分别为17.43mg/L(粉剂)和18.38mg/L(胶囊),达峰时间为9,70h(粉剂和)和8.21h(胶囊),消除半衰期(t1/2ke)为19.90h(粉剂)和19.42h(胶囊),以上各项参数经统计学处理均无明显意义,胶囊的相对生物利用度为104.72%,口服该药后有少量自尿中以原形排出体外,给药后2h内分别排出给药量的11.30%(粉剂)和11,29%(胶囊)。 相似文献
60.