全文获取类型
收费全文 | 1202篇 |
免费 | 68篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 47篇 |
妇产科学 | 39篇 |
基础医学 | 132篇 |
口腔科学 | 42篇 |
临床医学 | 109篇 |
内科学 | 236篇 |
皮肤病学 | 19篇 |
神经病学 | 145篇 |
特种医学 | 22篇 |
外科学 | 176篇 |
综合类 | 20篇 |
预防医学 | 64篇 |
眼科学 | 68篇 |
药学 | 70篇 |
中国医学 | 11篇 |
肿瘤学 | 42篇 |
出版年
2024年 | 2篇 |
2023年 | 15篇 |
2022年 | 43篇 |
2021年 | 38篇 |
2020年 | 28篇 |
2019年 | 42篇 |
2018年 | 45篇 |
2017年 | 31篇 |
2016年 | 73篇 |
2015年 | 44篇 |
2014年 | 63篇 |
2013年 | 88篇 |
2012年 | 122篇 |
2011年 | 109篇 |
2010年 | 62篇 |
2009年 | 31篇 |
2008年 | 57篇 |
2007年 | 58篇 |
2006年 | 62篇 |
2005年 | 61篇 |
2004年 | 48篇 |
2003年 | 39篇 |
2002年 | 23篇 |
2001年 | 9篇 |
2000年 | 12篇 |
1999年 | 9篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1990年 | 10篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有1272条查询结果,搜索用时 0 毫秒
91.
Isotamarixen - a new antioxidant and prolyl endopeptidase-inhibiting triterpenoid from Tamarix hispida 总被引:2,自引:0,他引:2
Sultanova N Makhmoor T Yasin A Abilov ZA Omurkamzinova VB Atta-ur-Rahman Choudhary MI 《Planta medica》2004,70(1):65-67
A new pentacyclic triterpenoid, 3alpha-(3",4"-dihydroxy- trans-cinnamoyloxy)- D-friedoolean-14-en-28-oic acid ( 1) has been isolated along with two known compounds, rhamnocitrin ( 2) and isorhamnetin ( 3) from the aerial parts of Tamarix hispida Willd. Compound 1 was found to be a potent antioxidant. In addition, compounds 1 - 3 showed significant inhibitory activity against prolylendopeptidase (PEP). 相似文献
92.
93.
Genc H Morita E Perrier ND Miura D Ituarte P Duh QY Clark OH 《Journal of the American College of Surgeons》2003,196(4):535-540
BACKGROUND: Minimally invasive parathyroid surgery with intraoperative parathyroid hormone testing has been reported to be as successful as a bilateral operation. This study aimed to determine whether the histologic findings and outcomes differ in patients with primary sporadic hyperparathyroidism treated by a focal or a bilateral parathyroid exploration with intraoperative parathyroid hormone testing. To make the two groups comparable all patients had a solitary parathyroid adenoma identified preoperatively. STUDY DESIGN: Eighty unselected patients with primary hyperparathyroidism and a single abnormal parathyroid gland identified preoperatively by sestamibi scanning or ultrasonography were included in this study. All patients had intraoperative parathyroid hormone testing. RESULTS: Forty-five patients had standard bilateral neck explorations and 35 patients had focal neck explorations. In the bilateral neck exploration group a single adenoma was found in 38 patients (84%), a double adenoma in 3 patients (7%), hyperplasia in 3 patients (7%), and carcinoma in 1 patient (2%). In contrast, a single adenoma was identified in all patients in the focal neck exploration group. Sestamibi scanning and intraoperative parathyroid hormone assay were accurate in 87% and 84%, respectively, in the bilateral neck exploration group and in 96.9% and 94.3%, respectively, in the focal neck exploration group. All patients were normocalcemic (mean followup 17 months). CONCLUSIONS: Patients with primary hyperparathyroidism having a bilateral exploration had about a 15% higher rate of multiple parathyroid tumors than did patient having a focal approach. Despite this observation all patients were normocalcemic postoperatively. This suggests that either some histologically abnormal parathyroid glands do not function or there will be recurrences in patients treated by a focused approach. Longterm followup will be necessary to determine whether patients treated by focal neck exploration will develop recurrent primary hyperparathyroidism. 相似文献
94.
Fabiana K. Kashiwabuchi Yasin A. Khan Murilo W. Rodrigues Jr Jiangxia Wang Peter J. McDonnell Yassine J. Daoud 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2013,251(8):1961-1965
Background
Post-cataract endophthalmitis has increased after introduction of clear cornea incisions (CCI). Laboratory models suggested that these incisions might not be competent at certain changes in intraocular pressure (IOP). Considering that side-port incisions (SPI) might behave similarly, the purpose of the present study was to determine the most stable side-port incision configuration.Methods
Using four cadaveric human eyes, four different side-port incisions (SPI) were created in each cornea: 1.5 mm and 2.5 mm squared tunnel, 1.5 mm and 2.5 mm stab tunnel. Fluorescein was placed on the eye, and the IOP varied from 10 to 80 mmHg. IOP at which each SPI started leaking was recorded. In the second part of the study, India ink was applied to the corneal surface at normal IOP, and then rinsed with balanced salt solution (BSS). The ink influx was recorded by planimetry. IOP was elevated to 80 mmHg, ink was reapplied, and IOP was dropped to 0 mmHg. Ink influx was measured again. Histological examination was used to visualize ink inflow into each incision.Results
There was no statistically significant difference in the IOP levels at which the different incisions leaked (p?=?0.52). A significant increase in the length of India ink ingress in all incision types was measured after IOP variation (p?<?0.05). The 2.5 mm squared incision showed the least increase in ink inflow in this test.Conclusion
All incision types of SPIs tested exhibited similar resistance to leakage after IOP variation. Good resistance to wound leakage may not predict adequate resistance to the inflow of bacterial-sized particles into the wound. 相似文献95.
Turgut S Polat A Inan M Turgut G Emmungil G Bican M Karakus TY Genc O 《Indian journal of pediatrics》2007,74(9):827-830
Objective Anemia is a widespread problem among infants and children in many parts of the world, and it is often associated with some
trace elements (iron, zinc, copper) and heavy metals (cadmium and lead). Aim of this study was to investigate the relationship
between anemia and these elements.
Methods This research was performed on 256 children (mean age 6.8 ± 0.2) living in Denizli city center. We observed iron deficiency
anemia (IDA) in 23 children, iron deficiency without anemia (ID) in 36 children and only anemia (ferritin level normal) (OA)
in 18 children, and 179 children were found healthy and they were regarded as controls (C). Blood samples were taken from
subjects and the concentrations of zinc, copper, iron, cadmium and lead in serum were measured with atomic absorption spectrophotometer.
Results The levels of copper, cadmium and lead in serum were significantly higher in children with IDA than those of controls (p<0.05,
p<0.05, p<0.01, respectively). The other elements in the serum of ID were not different from controls. 相似文献
96.
Kim SH Song JH Chung DR Thamlikitkul V Yang Y Wang H Lu M So TM Hsueh PR Yasin RM Carlos CC Pham HV Lalitha MK Shimono N Perera J Shibl AM Baek JY Kang CI Ko KS Peck KR;ANSORP Study Group 《Antimicrobial agents and chemotherapy》2012,56(3):1418-1426
Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin-nonsusceptible pneumococci (MIC, ≥ 4 μg/ml) was 4.6% and penicillin resistance (MIC, ≥ 8 μg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A. 相似文献
97.
Polyarteritis nodosa (PAN) is a systemic disease which involves the kidneys in 70% of cases. We report a case in which the pre-operative diagnosis was perirenal abscess or perirenal tumour, but at operation a perirenal haematoma was found. After pathological examination, it was recognised as renal involvement with PAN. The diagnosis of PAN is often difficult. Renal arterial changes, including aneurysm formation, are frequent. Since Kussmaul and Maier first described PAN in 1866, diagnosis has remained difficult because it is based upon tissue examination obtained at biopsy or post-mortem. In this report we present a case of renal involvement of PAN resulting in a perirenal haematoma due to spontaneous rupture of intrarenal arterial aneurysms. 相似文献
98.
OBJECTIVES: To demonstrate initial results using Khan Kinetic Treatment (KKT) as a chronic neck pain treatment and to present pain control mechanistic theory on which the treatment is based. METHODS: A self-reported functional assessment, neck pain questionnaire, and pain medication dose were used as outcome measures for 44 matched patients randomly split into 2 groups ("treatment" and "control"). The treatment group underwent a treatment period consisting of several individual KKT treatments, whereas the control group continued conventional therapy. RESULTS: Compared with a control group, the treatment group lowered both their self-recorded neck pain scores (P=0.012) and pain medication dose (P=0.048), although current functional assessment questionnaires (range of motion, overall activity, and recreation/work activities) did not detect changes (P=0.233, 0.311, and 0.472, respectively). DISCUSSION: We address the theory of the pain control mechanisms of the device in detail. Although we await randomized placebo controlled trials and additional results from ongoing mechanistic studies, initial results show that KKT is potentially an effective treatment for chronic neck pain and may contribute to the reduction of pain relieving medication. 相似文献
99.
Alia Alawneh Hesham Yasin Ghaleb Khirfan Bashar Abu Qayas Khawla Ammar Dalia Rimawi Pål Klepstad 《Supportive care in cancer》2016,24(6):2455-2462
Purpose
Health related quality of life (HRQOL) is an important outcome in cancer care and needs assessment by a valid questionnaire. HRQOL questionnaires need to be validated after translations to other languages and cultural settings. The purpose of this study is to evaluate the psychometric properties of the Arabic version of the European Organization for Research and Treatment of Cancer Quality of Life 15 items Questionnaire for Palliative Care (EORTC QLQ-C15-PAL).Methods
This is a cross-sectional study of a convenient sample of inpatients with cancer.Results
One hundred seventy-five patients completed the EORTC QLQ-C15-PAL questionnaire. Cronbach’s alpha coefficient met the 0.7 alpha criterion. Confirmatory factor analysis met the goodness of fit criteria; goodness-of-fit index (GFI), comparative fit index (CFI), normed fit index (NFI) and non-normed fit index (NNFI) >0.90 and root mean square error of approximation (RMSEA) <0.06. All item-scale correlation coefficients exceeded the set value of 0.40, indicating satisfactory convergent validity. In terms of discriminant validity, all items in the questionnaire showed a higher item-scale correlation than item-other scale correlation, except for items 1 and 2 (physical function scale) that showed a higher correlation with fatigue. Construct validity was tested by item inter scale correlation coefficient. All constructs had correlation coefficient <0.70. External validity was tested by comparison of scores of patients who had metastasis and who did not have metastasis. Significant differences (P value <0.05) were found in all scales except for nausea. Age groups were compared and showed significant differences for physical function, fatigue, and global score of HRQOL.Conclusion
The Arabic version of the EORTC QLQ-C15-PAL is valid and reliable.100.
Nitric oxide contamination of hospital compressed air improves gas exchange in patients with acute lung injury 总被引:3,自引:0,他引:3
OBJECTIVE: We tested the hypothesis that NO contamination of hospital compressed air also improves PaO(2) in patients with acute lung injury (ALI) and following lung transplant (LTx). DESIGN: Prospective clinical study. SETTING: Cardiothoracic intensive care unit. PATIENTS: Subjects following cardiac surgery (CABG, n=7); with ALI (n=7), and following LTx (n=5). INTERVENTIONS: Four sequential 15-min steps at a constant FiO(2) were used: hospital compressed air-O(2) (H1), N(2)-O(2) (A1), repeat compressed air-O(2) (H2), and repeat N(2)-O(2) (A2). MEASUREMENTS AND RESULTS: NO levels were measured from the endotracheal tube. Cardiorespiratory values included PaO(2) were measured at the end of each step. FiO(2) was 0.46+/-0.05, 0.53+/-0.15, and 0.47+/-0.06 (mean+/-SD) for three groups, respectively. Inhaled NO levels during H1 varied among subjects (30-550 ppb, 27-300 ppb, and 5-220 ppb, respectively). Exhaled NO levels were not detected in 4/7 of CABG (0-300 ppb), 3/6 of ALI (0-140 ppb), and 3/5 of LTx (0-59 ppb) patients during H1, whereas during A1 all but one patient in ALI and three CABG patients had measurable exhaled NO levels (P<0.05). Small but significant decreases in PaO(2) occurred for all groups from H1 to A1 and H2 to A2 (132-99 Torr and 128-120 Torr, P <0.01, respectively). There was no correlation between inhaled NO during H1 and exhaled NO during A1 or the change in PaO(2) from H1 to A1. CONCLUSIONS: Low-level NO contamination improves PaO(2) in patients with ALI and following LTx. 相似文献