中国地鼠情绪唤醒水平评定量表的制定

为建立一套适合于中国地鼠情绪唤醒水平观测的评定方法,并验证其可靠性,在Ａｄｅｒ 情绪唤醒评定方法基础上进行修订,对中国地鼠进行试测,建立情绪唤醒水平划界分。结果显示总分以５ 分为界,能区分高／ 低情绪唤醒水平的中国地鼠;条目与量表总分呈中高度相关（ ｒ ＝ ０ ．３２６８ ～０ ．７３４７） ,量表总分重测信度良好（ ｒ ＝ ０ ．５８７４ ～０ ．６１０５） ,评定者评分一致性高,符合率达９５－２ ％     

大鼠饮盐行为的个体发生的研究

研究不同性别的发育期大鼠饮盐行为的发生年龄及其与大鼠血浆醛固酮（ＡＬＤＯ）水平之间的关系,为研究高血压病提供基础资料。方法：用自控泵经口腔导管给大鼠灌注３％盐水,记录大鼠的饮盐水量。结果：禁盐能引起１３ｄ龄及１３ｄ龄以上大鼠的饮盐行为。而不能引出１３ｄ龄以下幼鼠的饮盐行为。幼鼠的饮盐行为无显著的性别差异。这与禁盐引起各年龄组大鼠的血浆ＡＬＤＯ水平都显著升高的现象不一致。结论：大鼠饮盐行为的发生与大鼠的年龄有关,与大鼠脑的发育,特别是与大鼠的饮盐中枢的发育及完善有关。     

道路桥梁桩基础沉降性状及计算分析

由桥梁桩基实测沉降的统计分析,揭示了桩端持力层的性质对桩基的沉降性状具有显著的影响;经5组桩基进一步的计算比较,表明桩端持力层压缩模量计算值的离散是造成桩基计算沉降偏离实际沉降的主要原因之一.提出了用静力触探Ps值修正Es值的方法,并且讨论了桩基附加应力的计算及计算沉降经验系数(ψs)的取值问题.     

Development and clinical application of dental spot weld & heat-treat tri-uses device]

A spot weld & heating treatment tri-uses device based on modern mechanical-electric technique, was developed for dental spot weld, stainless steel orthodontic wire heating-reversion and Ni-Ti orthodontic wire heating-overload metamorphism. The device will be very helpful instrument in orthodontic clinic. The paper not only described the operating methods of the device, but also discussed the Performance-improved principles of stainless steel orthodontic wire and the principles of heating overload metamorphism of Ni-Ti orthodontic wire.     

左旋四氢巴马汀对单个豚鼠心室肌细胞钙电流的阻滞作用

AIM: To study the effect of l-tetrahydropalmatine (l-THP) on L-type calcium channel. METHODS: Patch clamp technique (whole cell recording) was used to record L-Ca2+ current in single cardiac myocyte. RESULTS: 1) l-THP 1, 10, and 100 micromol.L-1 reduced ICa-max from (999 +/- 93) pA to (700 +/- 111) pA, (582 +/- 66) pA, and (420 +/- 112) pA (n = 6, P < 0.01), respectively. 2) l-THP reduced the voltage at half-maximal inactivation (V1/2) of L-Ca2+ channel to more negative potentials by 9 mV (n = 5, P < 0.05). 3) l-THP caused both tonic and use-dependent reduction of Ca2+ current. Tonic block of l-THP on Ca2+ current was 46% +/- 8% (n = 6, P < 0.01). The degree of use dependent blocking was 13.5% +/- 2.4% (n = 6, P < 0.05) at 1 Hz, the degree increased to 44% +/- 5% (n = 6, P < 0.01) at 3 Hz. 4) l-THP delayed half-recovery time of Ca2+ channel recovery from inactivity from (94 +/- 39) ms to (170 +/- 42) ms(n = 6, P < 0.01). CONCLUSION: l-THP has a moderate inhibitory effect on L-Ca2+ current.     

The von-Hippel-Lindau (VHL) tumor suppressor gene is not mutated in sporadic ovarian carcinomas

The von Hippel-Lindau (VHL) tumor suppressor gene has been shown to be mutated frequently not only in neoplasms from von Hippel-Lindau disease, but also in sporadic clear cell renal carcinoma. In order to reveal the possible role of the VHL tumor suppressor gene in the development of ovarian carcinoma, a total of 71 primary sporadic ovarian carcinomas were analyzed for the presence of mutations in the exon 2 and 3 of the VHL tumor suppressor gene, using the polymerase chain reaction with single strand conformation polymorphism analysis. No mutations in the VHL gene were found in any of the tumors analyzed. This result shows that the VHL tumor suppressor gene does not play a major role in the tumorigenesis of sporadic ovarian carcinoma.     

"气至病所"针法治疗臀上皮神经损伤的疗效观察

目的：观察气至病所针法的临床治疗效果。方法：将120例臀上皮神经损伤病例随机分成“气至病所”针法组与常规针法组进行对照观察。结果：气至病所组治愈率优于常规组(P＜0．01)。结论：“气至病所”针法是一种治疗臀上皮神经损伤的有效方法。     

Use of YAG laser combined with mucosal suturing for the treatment of polypoid vocal cord]

To improve low-pitched voices in cases with polypoid vocal cords, YAG laser irradiation combined with a mucosal suturing technique was attempted in 9 female cases with severe polypoid changes in their vocal cords. A YAG laser beam (5 to 10 W) was used to irradiate the upper surface of the polypoid vocal cord. The polypoid content of the cord was gradually coagulated, and the free edge of the cord appeared to slide up toward the burned area. The polypoid content was then removed and squeezed through an open wound made in the burned area using a conventional method. Bleeding was successfully controlled using the laser. After the excessive mucosal margin was trimmed and the contour of the vocal cord was adjusted, the wound was closed by 7-0 monofilament absorbable suture. Suturing was relatively easy because the mucosal edge was also coagulated. Postoperative evaluations of voice quality revealed an improvement in the GRBAS scale of voice quality as well as an elevation in voice pitch and an upwards shift in the voice range in all cases.     

p27kip1及p53基因蛋白与恶性卵巢上皮性肿瘤预后的关系

目的　探讨 p2 7kip1和 p5 3基因蛋白在恶性卵巢上皮性肿瘤中的表达及其与预后的关系。 方法　1992年 11月至 1999年 12月应用免疫组化检测 5 6例恶性卵巢上皮性肿瘤石蜡切片中 p2 7kip1和p5 3基因蛋白表达情况 ,并应用Kaplan -Mier法及多变量Cox比例风险回归模型分析患者预后。 结果　 5 6例恶性卵巢上皮性肿瘤患者的 p2 7kip1基因蛋白表达率为 4 1 1% ;p5 3基因蛋白表达率为 4 8 2 % ,两种基因蛋白表达比较 ,差异无显著性 (P >0 0 5 )。p2 7kip1及 p5 3基因蛋白表达与肿瘤的病理分级有关 ( P <0 0 5 ) ,与其他临床病理特征无关。单因素分析 :p2 7kip1及 p5 3基因蛋白表达与患者的中位生存时间、生存曲线各时点生存率密切相关。 结论　p2 7kip1基因蛋白表达对恶性卵巢上皮性肿瘤的预后有显著影响 ,而 p5 3基因蛋白表达与预后关系不显著