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81.
In rabbit platelet rich plasma (PRP), 5-hydroxytraptamine (5-HT,0.03~3μmol/L) induced decrease in light transmission (DLT) dose-de pendently with centralization, as revealed by electron microscopy. However, 5-HT did not induced platelet aggregation and release reaction. 5-HT-induced DLT was inhibited by methysergide (0.3~30μmol/L), indomethacin (0.3~10μmol/L) and PGE_1 (0.01~0.3μmol/L) in a dose-dependent manner, but not EGTA(0.3~3mmol/L). Collagen(Coll), arachidonic acid (AA), adenosine diphosphate (ADP) and a stable thromboxane A2 analoge(STA_2) also induced DLT before aggregation by themselves, which was also inhibited by PGE_1, but not inhibited by EGTA except for Coll However,Coll-, AA-, STA_2-and ADP-induced DLT were reduced by pretreatment of PRP with 5-HT dose-depen-dently. The duration of DLT by Coll and AA were decreased from 151.4±5.93 sec and 15(?)38±0.60sec to 45.44±4.04 sec and 9.00±1.25 sec respectively ((?)±s(?) P<0.01), but not by ADP and STA_2, 3μmol/L of ADP-and 0.3μmol/L of STA_2-induced aggregation which was not accompanied with release reaction were enhanced by 5-HT pretreatment, but in those (Coil 5μg/ml, AA 100~200μmol/L and STA_2 1~3 μmol/L) with release reaction, the amount of adenosine triphosphate(ATP)were suppressed significantly (P<0.001) by 5-HT pretreatment without the effect on the magnitude of aggregation, The mobilization of cytosolic free calcium concentration ([Ca~(2+)]i) was observed after 5-HT treatment in single washed platelet, the results indicated that the basic level of [Ca~(2+)] i was 64.78±3.24nmol/L and this level was increased dose-dependently and significantly at 30 sec after administration of 5-HT and the time of peak value of [Ca~(2+)] i was at 90~100 sec.The similar time courses of suppression of ATP released during aggregation, in cases of Coll(5μg/ml), AA (200μmol/L) and STA_2(3μmol/L), by 5-HT were also found in the present experiment. 相似文献
82.
腰椎峡部裂的CT诊断 总被引:12,自引:2,他引:10
目的:回顾性分析腰椎峡部裂的CT表现并讨论其诊断与鉴别诊断,材料与方法,23例患先行腰椎侧位扫描定位图像,采用与椎间盘平行的角度,自病变脊椎的上一椎体下缘边续发描至于下椎体上缘,层厚4或5mm必要时在峡部行2mm,层厚扫描,结果;23例中,累及双侧21例,单侧2例,发生在L516例,L47例,CT表现为同一脊椎关节突间的低密度裂隙,出瑞椎弓根下缘平面,走行不规则,裂隙可宽可窄,表面不光滑。 相似文献
83.
本文根据Svennerholm和蒋谷人等的方法略加改良,测定了蚌埠地区113例正常人,71例恶性肿瘤患者和82例非肿瘤疾病患者血清脂质结合唾液酸(LSA)的含量。正常值为12.4mg/dl(SD=±3.6mg/dl),71例不同肿瘤患者的平均值为28.2mg/dl(SD=±9.7mg/dl),阳性率为88.7%,82例非肿瘤疾病患者的平均值为16.82mg/dl(SD=±5.4mg/dl),假阳性率为17%。方法的灵敏度,重复性(平均CV=3.6%)和回收率(平均回收率=101.4%)测定结果是满意的。本研究的初步结果表明,血清LSA测定对肺癌、白血病、胃癌和食管癌具有一定的临床诊断价值。 相似文献
84.
85.
86.
Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less mollusk Dolabella auricularia (Pettit GR, Kamano Y, Herald CL, Tuinman AA, Boettner FE, Kizu H, Schmidt JM, Baczynskyj L, Tomer KB and Bontems RJ, J Am Chem Soc 109: 6883-6885, 1987). Since our preliminary studies demonstrated that dolastatin 10 inhibited tubulin polymerization and the binding of radiolabeled vinblastine to tubulin, an initial characterization of the properties of dolastatin 10 included a comparison to other antimitotic drugs interfering with vinca alkaloid binding to tubulin (vinblastine, maytansine, rhizoxin, and phomopsin A). Dolastatin 10 inhibited the growth of L1210 murine leukemia cells in culture, with a concordant rise in the mitotic index, and its IC50 value for cell growth was 0.5 nM. Comparable values for the other drugs were 0.5 nM for maytansine, 1 nM for rhizoxin, 20 nM for vinblastine, and 7 microM for phomopsin A. IC50 values were also obtained for the polymerization of purified tubulin in glutamate: 1.2 microM for dolastatin 10, 1.4 microM for phomopsin A, 1.5 microM for vinblastine, 3.5 microM for maytansine, and 6.8 microM for rhizoxin. Dolastatin 10 and vinblastine were comparable in their effects on microtubule assembly dependent on microtubule-associated proteins. Preliminary studies indicated that dolastatin 10, like vinblastine, causes formation of a cold-stable tubulin aggregate at higher drug concentrations. We confirmed that rhizoxin, phomopsin A, and maytansine also inhibit the binding of radiolabeled vinblastine and vincristine to tubulin. Dolastatin 10 and phomopsin A were the strongest inhibitors of these reactions, and rhizoxin the weakest. Dolastatin 10, phomopsin A, maytansine, vinblastine, and rhizoxin all inhibited tubulin-dependent GTP hydrolysis. The greatest inhibition of hydrolysis was observed with dolastatin 10 and phomopsin A, and the least inhibition with rhizoxin. 相似文献
87.
Jinyong Lin Wei Sun Enjiang Li Sihui Wang Jingwen Bai Haixian YangTianjin Eye Hospital Tianjin China Tianjin Medical Cellege Tianjin China 《眼科学报》1994,(1)
Eighteen trabeculectomy specimens of congenital glaucoma were examined by light and transimssion electron microscopy. The results showed that the primary anomalies in congenital glaucoma included the developmental defects of trabecular meshwork, excessive collagen fibrils in the trabecular matrix, shifting forward of ciliary muscle fibres and persistent mesenchymal tissues in the anterior-chamber angle. The authors also pointed out the importance of the secondary lesions of the trabecular meshwork in the pathogenesis of congenital glaucoma. Eye Science 1994; 10:50-56. 相似文献
88.
急性白血病形态学与免疫学分型 总被引:4,自引:1,他引:3
目的:分析急性白血病形态学分型(FAB分型)与免疫学分型的相互关系。方珐:选择我院2000~2002年确诊的169例初诊急性白血病进行形态学与单克隆检测免疫学分型比较。结果:106例FAB分型为急性髓细胞白血病(AML),免疫学特征有M3 HLA-DR(-),M4、M5有CD14( )特征,及有淋系相关抗原表达;63例FAB分型为急性淋巴细胞白血病(ALL),免疫学分型有单纯髓系4例,B-ALL18例,T-ALL5例,变异型23例,混合型13例。结论:在AML中(除M0、M7),不如形态学直观、分型仔细。对于ALL病FAB分型不如免疫学分型,对于M0、M7,只有依靠免疫学分型。FAB分型与免疫学分型两者要相互结合,互相补充,才能更好地反映急性白血病的状况,对临床治疗方案的选择及判断预后有重要意义。 相似文献
89.
OBJECTIVE: To investigate the factors responsible for Pseudomonas aeruginosa nosocomial cross-infection in the intensive care unit (ICU) and provide effective measure for the prevention and management. METHODS: The homology of 7 Pseudomonas aeruginosa strains isolated from the patients in the ICU and the environment was examined by biological, serological, drug-resistance and plasmid analysis. RESULTS: The results of serological and plasmid analyses had good consistency, which demonstrated that the 7 Pseudomonas aeruginosa strains originated from solution in the oxygen humidifier, with uniform serological and plasmid type, and belonged to the same clone with cross-infection by contact between the patients or nursing staff and the objects in the ICU. CONCLUSION: Serological and plasmid analyses are more practical for identifying the sources of Pseudomonas aeruginosa cross-infection, which can be prevented by strict disinfection of the instrument and supervision of the nursing staff in the ICU. 相似文献
90.
对综合大学医学生心理健康干预的研究 总被引:1,自引:0,他引:1
[目的 ]探讨具有改善医学生心理健康水平的较长期效果 ,并可在自然条件下提高医学生心理素质的有效途径 .[方法 ]采用 16种人格因素量表多角度地分析当代医学生的心理素质状况 ,在此基础上 ,连续 2年先后在全年级开展多种形式的心理健康干预活动 .[结果 ]医学生的人格可塑性很强 ,通过多种途径的心理健康教育及心理辅导 ,完全能改善医学生的某些人格因素 ,提高其心理健康水平 .[结论 ]心理健康干预活动对于提高医学生心理健康水平是有效的 相似文献