精神分裂症LPO、GPX和VE含量测定

对56例精神分裂症患者和42例正常对照组的血清过氧化脂质(LPO)、谷胱甘肽过氧化物酶(GPX)和维生素E(VE)水平进行了测定,结果表明:LPO含量明显高于对照组(P<0.05),GPX活性和VE含量明显低于对照组(P<0.01);LPO与病程呈正相关(γ=0.361,<0.01),GPX和VE与病程呈负相关(γ±-0.383～-0.403,P<0.01);LP0与GPX和VE呈负相关(γ=-0.378～-0.411,P<0.01)。结合文献,认为自由基代谢异常在本病的发病机制中具有一定作用。     

围手术期癌症病人心理状况及心理干预的作用

目的 :了解围手术期癌症病人抑郁、焦虑、恐惧状况及心理干预对其产生的影响。方法 :对10 8例癌症病人手术前行心理评估 ,其中 6 1例在围手术期行心理干预 ,即一般性心理支持治疗、个别心理治疗、病人互助治疗、家庭和社会支持治疗、肌肉放松和意念引导等。对照组 47例仅采取手术治疗。观察两组治疗前后抑郁、焦虑、恐惧情绪变化。结果 :围手术期癌症病人存在较严重的不良情绪 ,心理干预能明显改善其抑郁、焦虑、恐惧情绪 ,有助于其躯体疾病的治疗及生存质量的提高。结论 :外科医护人员应重视癌症病人围手术期存在的不良心理 ,积极进行心理干预能有效改善其情绪 ,有助于躯体疾病的治疗及生存质量的提高。     

基于CMR-FT机械离散在心肌疾病中的应用研究进展

心肌机械离散为应变的衍生参数,可更细微地反映心肌微观结构和电生理的改变,有助于对心肌疾病引起的心律失常等主要不良心血管事件的风险分层。心脏磁共振（CMR）具有更高的空间分辨力和软组织分辨力,测量的机械离散更准确,但目前基于CMR组织特征追踪（CMR-FT）技术获得机械离散的研究很少。就基于CMR-FT的心肌机械离散的概念和评价方法及其在缺血和非缺血性心肌病中的应用研究进展予以综述。     

乳腺癌患者社会心理特征的研究

目的　研究乳腺癌患者的社会心理特点和心身健康状况。方法　运用临床心理评定量表 (LES、EPQ、CS、SSQ、SCL 90 )评定 40例乳腺癌患者遭遇的生活事件、人格特征、应付方式、社会支持、心身健康状况 ,与 40例健康者相比较。结果　乳腺癌患者组病前经历的生活事件总频数及应激强度、负性生活事件频数及应激强度、神经质分、消极应付方式评分显著较多 ,社会支持总分、客观支持分、主观支持分、支持利用度显著较低 ,SCL 90除敌对、恐怖因子外其他因子分增高均具有显著性。结论　乳腺癌患者的社会心理因素有自身的特点 ,应采取积极的社会心理干预措施。     

Cerebral venous sinus thrombosis in Behçet’s disease: a retrospective case-control study

The objective of the study is to investigate the clinical features of Behçet’s disease (BD) complicated with cerebral venous sinus thrombosis (CVST). We retrospectively analyzed the clinical features of age- and gender-matched BD patients with and without CVST. Of the 840 BD patients enrolled, 21 (2.5%, 11 female, mean age 30.3 ± 9.5) were diagnosed as CVST. Eighteen patients (85.7%) developed neurologic manifestations after BD onset, with an average interval of 47.6 months (SD 36.1). Onset of neurologic symptoms was mostly progressive (89.5%), with headache (95.2%) being the most common symptom. Intracranial hypertension occurred in 17 cases (89.5%). Thrombosis was detected mostly in transverse (71.4%) and superior sagittal (66.7%) sinuses, with more frequently (66.7%) dual or multiple sinuses involved. In addition, extra cranial thrombosis was presented in 11 cases. Cerebral infarction was presented in four cases. Compared with BD patients without CVST, the prevalence of extra cranial vascular involvement (52.4 versus 20.6%; P = 0.005) and BDCAF 2006 score (3.7 ± 1.4 versus 1.8 ± 1.3; P = 1.7863 × 10^?7) was higher in BD patients with CVST. During a median 7-month follow-up (range 0.3–88.8 months), 18 patients (85.7%) achieved remission following glucocorticoid, immunosuppressant therapy, anticoagulants, and dehydration, although 3 patients experienced (14.3%) flare. No death was reported. CVST is rare complication of BD and predominately progressively developed in active BD and after BD onset. It typically features intracranial hypertension syndrome and is frequently complicated with extra cranial thrombosis; thus, systemic thrombus screening is highly recommended. Promptly, diagnosis and aggressive treatment are keys to improve the prognosis.     

Beh?et's Disease Complicated with Thrombosis: A Report of 93 Chinese Cases

To investigate the clinical features of Behçet''s disease (BD) complicated with thrombosis.Medical records of patients with BD at Peking Union Medical College Hospital from 1993 to 2013 were reviewed to identify thrombosis.Of the 766 patients with BD, 93 patients (16 female and 77 male) developed thrombosis. The most common thrombosis was extremity vein thrombosis (86.0%), including deep vein thrombosis (n = 78) and superficial thrombophlebitis (n = 4). The other thrombosis types associated with BD in descending frequency of order were: vena cava thrombosis (30.1%), pulmonary thromboembolism (15.1%), cerebral venous thrombosis (CVT) (12.9%), intracardiac thrombosis (8.6%), Budd–Chiari syndrome (7.5%), and renal vein thrombosis (4.3%), etc. Venous thrombosis is more frequent than arterial thrombosis, and most of patients (94.6%) experienced multiple thrombosis. A male predominance of extremity vein thrombosis and positive pathergy test, and a female predominance of CVT and genital ulcers were noted. All of these patients exhibited active disease during the emergence of thrombotic events. After treating with glucocorticosteroids, immunosuppressants, and/or anticoagulants, the thrombosis resolved in 89 patients. Three patients died from aneurysm rupture, myocardial infarction and Budd–Chiari syndrome, respectively. One patient with septic shock discontinued therapy during follow-up.Thrombosis in BD patients is male predominance, mainly multiple and venous thrombosis is more common. Active disease patients are prone to thrombosis, which suggest the key role of immunosuppressive therapy for the complication.     

食道调搏心负荷二维超声心动图试验评价冠心病介入性治疗疗效

目的 探讨ＴＥＡＰ－２ＤＥ试验对ＣＨＤ诊断价值及其一对介入性治疗效果的评价。方法 １９９５年４月￣１９９８年９月之间３８例在我院住院的ＣＨＤ患,先期行ＴＥＡＰ－２ＤＥ试验及ＣＡＧ检查,并在１周后接受冠状动脉介入性治疗（ＰＴＣＡ或ＰＴＣＡ＋Ｓｔｅｎｔ）,分别在１、３、６、１２个月用ＴＥＡＰ－２ＤＥ评价介入治疗的效果。结果 ＴＥＡＰ－２ＤＥ与ＣＡＧ相比,检出冠脉狭窄的符合率相似。ＴＥＡＰ－２ＤＥ观察     

牛磺酸钙的合成研究

利用中和反应合成了牛磺酸钙 ,用元素分析和核磁共振谱确定了其组成为Ca(NH2 CH2 CH2 SO3) 2 ,并测定了它的溶解度。该方法简单 ,产率和纯度较高     

肾活检新技术装置

目的探讨一种操作简便、成功率高、并发症少的肾活检技术。方法应用自动同步负压肾穿装置及专用穿刺针进行肾活检。结果肾活检２００例,成功率９９５％,２例出现肉眼血尿。结论自动同步负压肾穿装置具有简便易行、成功率高、并发症少等优点。     

SEAP型人工膝关节置换的术后疗效--五年以上随访研究

目的：探讨ＳＥＡＰ型人工膝关节置换术（ＴＫＡ）的术后疗效。方法：采用ＳＩＣＯＴ／ＩＤＥＳ标准,对４５ 例（６５ 个关节）实施ＳＥＡＰ型ＴＫＡ患者进行随访、评估和统计学分析。随访时间为５２～８６ 个月（平均５ 年３ 个月）。结果：在能调查的２９ 例４３ 个关节中,疼痛膝占２３％ 。ＲＯＭ 均保持了手术时所改善的范围,而且术前有屈曲挛缩者也获得显著改善（Ｐ＜ ０．０１）。ＦＴＡ 及人工假体设置位置同手术时相比无明显改变。２ ｍ ｍ 以上ＲＬＺ的发生主要见于股骨髁后方和胫骨外侧。结论：ＳＥＡＰ型ＴＫＡ的中期疗效满意,但持续性长期随访十分必要