复发性卵巢上皮癌二次细胞减灭术62例分析

目的 探讨复发性卵巢上皮癌二次细胞减灭术的意义及可行性。方法 62例复发性卵巢上皮癌接受了二次细胞减灭术。其中48例手术成功，14例仅做探查术。术式包括部分肠切除、肠修补、脾切除、残余大网膜切除及其它转移瘤切除。仅作探查术者是由于转移癌浸润大血管及胰十二指肠等重要脏器，肠系膜呈蜡肠状等。术后辅以铂剂为主的联合化疗。结果 残余瘤直径小于2cm的27例2年和5年存活率分别为40．7％及14．8％。残余瘤大于2cm的35例只有1例存活超过2年（2．9％）。结论 成功的二次肿瘤细胞减灭术能提高患者的存活率。术前作好检查筛去不适合手术病例会提高成功率。     

中医辨证治疗慢性肾功能衰竭57例临床观察

目的 :观察中医辨证分型治疗慢性肾功能衰竭(CRF)的临床疗效。方法 :采用中医辨证治疗和正常组对照 ,观察其疗效及血清BUN与Cr的变化。结果 :气阴两虚型、肝肾阴虚型以肾功能代偿期及氮质血症期为主 ;脾肾气(阳)虚型以氮质血症期及尿毒症期为多 ;阴阳两虚型以尿毒症期为最多。各型BUN与Cr明显高于正常组 ,而以阴阳两虚型最高 ;气阴两虚型、肝肾阴虚型、脾肾气(阳)虚型的疗效及降低BUN与Cr作用尤为显著。结论 :CRF患者各型与西医肾功能分期关系密切 ,中医辨证治疗对CRF有明显的改善作用。     

Vojta and Bobath combined treatment for high risk infants with brain damage at early period

BACKGROUND: In the process of early screening and interventions to high risk infants with brain damage, the occasion and choosing methods of interventions and the combined application of different interventions are still at the exploratory phase. OBJECTIVE: To observe the efficacy of early intervention using Vojta and Bobath combined treatment in high risk infants with brain damage, and investigate the effect of early rehabilitation on the prognosis. DESIGN: A randomized controlled comparative observation. SETTING: Daqing Oil Field General Hospital of Heilongjiang Province. PARTICIPANTS: Eighty-four high risk infants younger than 1 year were selected from the Department of Pediatrics, Daqing Oil Field General Hospital of Heilongjiang Province from October 2005 to October 2006, including 52 boys (62%) and 32 girls (38%). The treatment started at the age of 0–3 months in 11 cases (13%), 4–6 months in 28 cases (33%), 7–9 months in 35 cases (42%), and 10–12 months in 10 cases (12%). Infants with at least two of the followings were enrolled, including 7 Vojta abnormal postural reflexes, slow or disorder of motor development, increase of muscular tension, postural abnormality, primary reflection residual and CT/MRI abnormalities. Informed consents were obtained from their guardians. The 84 infants were randomly divided into treatment group (n =42) and control group (n =42). METHODS: All the children were intravenously injected with cerebroprotein hydrolysate injection or cattle encephalon glycoside and ignotin injection, 10 times as a course for 2–5 courses; Besides, the infants in the treatment group also received early rehabilitative training of Vojta and Bobath combined treatment, once a day, 40 minutes per time, 5 times a week followed by a 2-day rest, 1 month as a course, and totally 2–5 courses. The Vojta method was to facilitate the automatic regulation by reflexlocomotion. Bobath method was to inhibit abnormal posture but facilitate the normal one, thus it is also called neurodevelopmental therapy realized by reflex inhibition and facilitation. The rehabilitation was evaluated clinically using Gesell Development Schedules (GDS) after the courses when the infants were 1 year old. GDS included five aspects of adaptive behavior, gross motor, refine motor, speech, individual-social behavior. The developmental quotient (DQ) could be calculated according to their development. DQ=developmental age/actual age×100, < 85 points was taken as abnormal; The higher the DQ value, the better the development. ② Evaluation of efficacy: Cured: Developmental order reached normal or generally normal, abnormal posture disappeared, muscular tension ameliorated, symmetric limbs' motor function, free movement, normal intelligence, powerful reaction, and clear speech. Significant effect: Developmental order tended to normal, abnormal posture disappeared incompletely, muscular tension ameliorated incompletely, transient pause in the flexion and extension of limbs, good reaction, and improved intelligence. Effective: Developmental order improved to a certain degree, muscular tension ameliorated, limbs' motor function and posture improved as compared with before treatment, but still under control, intelligence improved a little. Invalid: No obvious changes before and after treatment. Total significant effective rate=(cured cases+cases of significant effect)/total cases×100%. ③ The enumeration data and measurement data were compared with chi-square test and t test respectively. MAIN OUTCOME MEASURES: Clinical efficacy and GDS results at 1 year old in both groups. RESUTLS: All the 84 infants were involved in the analysis of results. ① Efficacy: The total significant effective rate in the treatment group was higher than that in the control group (93%, 74%, χ2=4.2, P < 0.05). ② Results of GDS evaluation: The DQ values of individual intercourse and social adaptation in the treatment group (93.57±11.23, 95.13±9.32) were higher than those in the control group (88.27±10.18, 90.10±10.67, t =2.267, 2.301, P < 0.05); The DQ values of gross motor, fine motor and speech in the treatment group (90.78±10.20, 98.63±9.23, 93.69±11.31) were higher than those in the control group (84.32±11.33, 87.80±8.61, 85.52±10.61, t =2.746, 5.560, 2.746, P < 0.01). The interventional effects on each functional area were significant, especially the gross motor, fine motor and speech. CONCLUSION: The Vojta and Bobath combined treatment on the basis of drug therapy can improve the general developments of abilities in motor, intelligence, social intercourse, social adaptation and speech of high risk infants with brain damage, also can improve the curative efficacy.     

生活事件及其影响因素的人群研究

目的　研究生活事件的分布及其影响因素。方法　以杨德森生活事件量表对简阳某厂１１６０ 名职工进行调查。结果　５０ 件主要生活事件中发生的前三位的生活事件分别是：住房紧张，对现职工作不满，以及恋爱订婚或工作学习压力大。各生活事件综合加权评分均分前三位生活事件是：住房紧张，对现职工作不满和家庭经济困难。该人群中男性生活事件综合加权分明显高于女性（Ｐ＜ ０．０１），中青年人群组生活事件得分最高。对影响生活事件的因素作多元回归分析，结果显示婚姻状况、疾病与生活事件呈正相关；性别、年龄与生活事件呈负相关。评分系统以综合加权法为优。结论　婚姻及疾病状况与生活事件关联较大     

Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay

Background  

Our previous proteomic study showed that the senescence marker protein (SMP30) is selectively present in the plasma of a murine model of acute liver failure (ALF). The aim of this study was to validate this SMP30 expression in the plasma and liver tissues of mice and humans with ALF.     

Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors

Background  

Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in Chinese patients with PGL.     

肠复康肛滴治疗胸腹部术后肠麻痹86例临床观察

目的观察肠复康肛滴液治疗胸腹部术后肠麻痹的临床疗效。方法选择胸腹部术后肠麻痹患者146例,随机分为治疗组86例,对照组60例;治疗组用肠复康肛滴,对照组用新斯的明、吗丁啉分别肌注和口服。结果治疗组在促进患者肠鸣音出现时间、复常时间及肛门排气、排便出现时间等方面,明显优于对照组(P<0.01);治疗组在腹胀、呕吐、腹痛等肠麻痹症状的起效时间、消失时间及3d内症状消除率等方面亦明显优于对照组(P<0.05或0.01)。结论肠复康肛滴对胸腹部术后肠麻痹具有良好的治疗作用,其临床疗效优于新斯的明及吗丁啉。