刘铁军基于"脏毒腑秽学说"辨治肝癌

刘铁军教授认为,基于"脏毒腑秽学说",肝癌应以脏毒立论.肝失条达,久病入络,毒伏脏腑是肝癌脏毒产生、发展的基础.脏毒流窜是肝癌并发症发生和肝癌转移的根本原因.临床将肝癌分为肝郁气滞、肝郁脾虚、肝郁血瘀、气虚血瘀、肝胆湿热、脏毒伤络、肝肾阴虚、脾肾阳虚、气血阴阳俱虚等证型,以肃清毒源为治疗根本原则,施以疏泄、化瘀、通腑、扶正四法,分别予柴胡疏肝散合金铃子散、逍遥散、血府逐瘀汤/复元活血汤、补中益气汤合血府逐瘀汤、龙胆泻肝汤合(或)茵陈蒿汤、大黄蛰虫丸、化癥散积方/一贯煎、真武汤/实脾饮、八珍汤加味治疗,大黄运用贯彻在治疗始末,体现扶正祛邪的特点.     

运动中跟腱断裂的原因及预防

目的:分析运动中跟腱断裂的原因和发生部位,找到预防的措施。方法:通过检索文献资料、调查访问和临床诊断等方法,对34例在运动中因非外力的原因造成跟腱断裂的个案进行分析。结果:34例全部为在运动中因非外力的原因造成跟腱急性闭合性断裂,其中30例为完全断裂,4例为不完全断裂。损伤的主要原因:①跟腱患有退行性病变,变得脆弱,易断裂。②跟腱部位过度疲劳。③热身活动不足。④技术动作不合理。⑤跟腱的退行性变化提前于肌肉造成的软组织活性不协调。⑥可能的原因:近几年来吃的转基因食品较多或吃的动物肉类所含激素成分较多,造成肌腱脆性增加。34例中有25例为跟腱中部断裂,占74%,即断点在跟腱止点上方3～5cm。34例中28例断端不整齐呈现马尾状,19例曾有慢性跟腱周围炎病史,且年龄平均在40岁以上。断裂部位集中,断裂类型较一致。结论:运动前应充分做好热身活动,防止运动中过度疲劳,严格控制营养素的摄取,尽量少补充含激素成分较多的肉类和转基因食品,以减少跟腱断裂情况的发生。     

用SKY骨扩张器行经皮椎体后凸成形术的手术配合

随着人口的老龄化,骨质疏松症已成为严重危害老年人健康的疾病之一.椎体骨质疏松的病人,在轻微的外力作用下即有可能发生压缩性骨折.传统治疗方法是卧床休息、药物镇痛、支具外固定等,但这些方法极易导致骨质进一步脱钙疏松,形成恶性循环[1].     

Effect of Jianpi-yangwei decoction on gut fungi in the patients with gastric cancer undergoing chemotherapy

Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with gastric cancer undergoing chemotherapy by increasing beneficial gut bacteria and decreasing harmful bacteria.The present study aims to investigate the effect of JYD on gut fungi in patients with gastric cancer undergoing chemotherapy.Methods:A total of 73 patients with gastric cancer undergoing chemotherapy were recruited.Twenty-nine patients in the chemotherapy group were given standard chemotherapy and 44 patients in the observation group were given JYD plus standard chemotherapy.A control group(55 cases)was recruited from the healthy medical examiners.After 3 months of treatment,life-quality score was evaluated and fecal microbiota was tested by high-throughput sequencing based on the 18S rRNA gene.Results:After treatment,life-quality score in the observation group was significantly lower than that in the chemotherapy group(P<0.05).There was no significant difference between the observation and control groups’diversity and richness indices of intestinal fungi.The Chao index for intestinal fungi in the chemotherapy group was significantly lower than that in the observation group(P<0.05).There was a significant difference between the control and chemotherapy groups in the intestinal fungi according to Shannon and Simpson indices(P<0.05).Linear discriminant analysis effect size analysis showed no significant differences among the three groups,but significant difference in intestinal fungi was observed between the observation group and the chemotherapy group.At the genus level,the relative abundance of the Aspergillus genus in the observation and control groups was significantly lower(P<0.05),the relative abundance of the Cutaneotrichosporon,Galactomyces,and Ganoderma genus taxa was significantly higher compared with those in the chemotherapy group(P<0.05),and there was no significant difference between the observation group and control group.Conclusion:JYD can ameliorate chemotherapy-induced fungal dysbacteriosis in patients with gastric cancer undergoing chemotherapy and improve the quality of life of patients.     

Movement disorders in women: A review

The field of women's health developed based on the recognition that there are important sex‐based differences regarding several aspects of medical illnesses. We performed a literature review to obtain information about differences between women and men for neurological movement disorders. We identified important differences in prevalence, genetics, clinical expression, course, and treatment responses. In addition, we found that female life events, including menstruation, pregnancy, breast feeding, menopause, and medications prescribed to women (such as oral contraceptives and hormone‐replacement therapy), have significant implications for women with movement disorders. Understanding this biological sex‐specific information can help improve the quality and individualization of care for women with movement disorders and may provide insights into neurobiological mechanisms. © 2013 International Parkinson and Movement Disorder Society     

Evidence that the LRRK2 ROC domain Parkinson's disease‐associated mutants A1442P and R1441C exhibit increased intracellular degradation

Mutations in the leucine‐rich repeat kinase 2 (lrrk2) gene are the leading genetic cause of Parkinson's disease (PD). In characterizing the novel ROC domain mutant A1442P, we compared its steady‐state protein levels, propensity to aggregate, and toxicity with the pathogenic R1441C mutant and wild‐type (WT) LRRK2. Mutant (R1441C and A1442P) and WT LRRK2 fused to green fluorescent protein (GFP) and FLAG were transiently expressed in HEK293 cells using plasmid constructs. Western analysis and fluorescence microscopy consistently demonstrated lower mutant LRRK2 protein levels compared with WT. A time‐course expression study using flow cytometry showed that WT LRRK2 expression increased initially but then plateaued by 72 hr. Conversely, R1441C and A1442P mutant expression attained 85% and 74% of WT levels at 24 hr but fell to 68% and 55% of WT levels by 72 hr, respectively. We found that proteasome inhibition markedly increased mutant LRRK2 to levels approaching those of WT. Taken together, our findings reveal increased intracellular degradation for both mutants. Furthermore, the impact of mutant and WT LRRK2 expression on HEK293 cell viability was assessed under normative and oxidative (hydrogen peroxide) conditions and found not to differ. Expression of WT and mutant LRRK2 protein gave rise to intracellular aggregates of similar appearance and cellular localization. In summary, we provide evidence that the novel A1442P mutant and the previously investigated R1441C pathogenic mutant exhibit increased intracellular degradation, a property reportedly demonstrated for the pathogenic LRRK2 kinase domain mutant I2020T. © 2013 Wiley Periodicals, Inc.