肾移植前后男性性生活状况比较

目的 :探讨肾移植前后男性性生活质量的变化。　方法 :将 86例男性肾移植病人分为低年龄组 (2 5～ 35岁 ,35例 )、中年龄组 (36～ 45岁 ,2 9例 )、高年龄组 (46～ 5 5岁 ,2 2例 ) 3组 ,分别调查病人患病前后、肾移植术后性生活能力、频率、性生活满意程度等性生活状况。　结果 :86例病人患病前均有性生活能力 ,患病后有性生活能力的 :低年龄组、中年龄组、高年龄组分别为 2 8.6 %,13.8和 9.1%。肾移植术后有性生活能力的 :低年龄组、中年龄组、高年龄组分别为 88.6 %、75 .9%和 6 3.6 %。　结论 :肾移植术后的性生活质量明显好于患病后 ,年龄越轻、恢复的越理想。     

巨大浆膜下子宫肌瘤的CT与MRI诊断

目的:探讨巨大浆膜下子宫肌瘤(giant subserous hysteromyoma,GSH)的CT与MRI表现,以期提高诊断水平。方法:回顾性分析15例GSH的CT平扫、增强扫描及14例MRI平扫1、0例增强扫描表现并与手术病理结果对照。结果:5例CT表现呈非均匀实性的GSH在增强后内部呈多个大小不等的结节状改变,其间可见分隔结构,4例呈非均匀实性的GSH增强后呈"漩涡状"混杂密度,3例GSH瘤体边缘见低密度带。MRI T1WI所有肌瘤表现为等、低信号,T2WI表现为低或混杂信号,5例瘤体内部为结节状改变,其间可见高信号分隔结构,7例瘤体边缘见低信号带。结论:GSH的CT与MRI表现有一定的特征性,具有较高的诊断价值。     

Implantation of Active Can Implantable Defibrillators in the right Pectoral Region

Routinely the active can ICD is placed in the left side pectoral position, which theoretically gives optimal conditions for a low defibrillation threshold. Some patients, bowever, demand a right pectoral position, which possibly could result in a bigger defibrillation threshold. A right pectoral position was used in 3 of 85 active can ICDs implanted in our institution from 1994. the DFT was 12 J in two and 18 f in one patient. Thus, right pectoral implantation is feasible and offers an alternative approach in selected patients.     

功能性内镜鼻窦手术的核心技术

自Messerldinger 1972年开始采用鼻内镜手术治疗慢性鼻窦炎至今已近40年[1],在我国也已经有20年的历史.1995年Kennedy将其命名为功能性内镜鼻窦手术(functional endoscopic sinus surgery,FESS)[2].时至今日,FESS仍然是慢性鼻窦炎最重要的治疗手段之一.     

Adrafinil-induced orofacial dyskinesia.

We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4-month period. They were secondly dramatically improved by tetrabenazine, a presynaptic dopaminergic depleting drug which was introduced after the 4-month adrafinil-free period.     

大鼠脑室系统出血模型的建立

目的 探讨建立稳定、制作过程简单、创伤小的大鼠脑室系统出血模型的方法 . 方法 取大鼠自体动脉血立体定向下注入右侧侧脑室建立大鼠腩室系统出血模型,对模型组和对照组大鼠在不同时间点进行神经行为学评分,并观察脑室及室周脑组织病理变化. 结果本方法 模型成功率为88.9%(16/18),注血后6h大鼠出现行为异常,7d后行为异常好转;光镜下观察发现注血后24h模型组大鼠室管膜连续性遭到破坏,细胞间隙增宽,室周脑组织轻度水肿及出现红色坏死神经元. 结论 本研究采用的造模方法 模型稳定,制作创伤小,病理变化接近临床.     

湿润烧伤膏治疗外伤性末节指(趾)骨外露体会

目的：探讨MEBO治疗骨外露的临床疗效。方法：对2005年10月至2006年2月处置外伤性指（趾）骨外露3例采用MEBO治疗。结果：3例创面全部愈合,时间均为3周。结论：MEBO治疗外伤性末节指（趾）骨外露简便,实用,疗效可靠,不影响美观。     

胶质瘤中LGI 1的突变及微卫星不稳定性研究

目的 为了检测人脑胶质瘤组织及胶质瘤细胞系LGI 1基因编码区中有无碱基突变及微卫星不稳定性(MSI)和杂合性缺失(LOH).方法 收集30例胶质瘤标本,2例脑膜瘤、2例瘤旁及2例颅脑损伤内减压脑组织标本及体外培养5个脑胶质瘤细胞系.提取组织标本及培养细胞基因组DNA.设计特异性引物分别扩增LGI 1各外显子序列,采用SSCP银染分析;扩增LGI 1微卫星序列,凝胶电泳银染分析;发现异常泳动条带进行DNA序列分析.结果 ①PCR-SSCP分析琼脂糖凝胶电泳检测有1例Ⅱ级胶质瘤标本未检测到第1 a外显子处扩增产物以及Ⅱ、Ⅲ级各1例胶质瘤标本均未检测到第8 c外显子处扩增产物.未在30例胶质瘤标本和4个脑胶质瘤细胞系中检测到电泳条带异常,在细胞系TJ905第5外显子处检测到电泳条带异常,经DNA测序分析证实确有突变.②在30例胶质瘤标本及5个细胞系中均未检测到MSI和LOH.结论 基因突变及MSI和LOH可能不是LGI 1在胶质瘤恶性进展过程中失活的主要原因.     

1,25-Dihydroxyvitamin D3 Exerts Opposing Effects to IL-4 on MHC Class-II Antigen Expression,Accessory Activity,and Phagocytosis of Human Monocytes

To investigate the differentiation and activation of monocytes, the combined effects of 1,25-dihydroxyvitamin D3 (D3) and IL-4 on human blood monocytes were examined with respect to expression of MHC class-II antigens, accessory activity, and phagocytic capacity. IL-4 was reported lo upregulate the expression of MHC class-II antigens and accessory activity of monocytes. The experiments described here demonstrate that D3 inhibits the expression of all three subtypes of MHC class-II antigens (HLA-DR, -DP and -DQ) as well as the accessory activity of monocytes. both in a dose- and time-dependent manner. However, D3 enhances the immunoglobulin- and complement-dependent phagocytosis by monocytes in a dose- and time-dependent manner. When monocytes are treated with both IL-4 and D3, the effects of D3 are reverted by IL-4. suggesting that IL-4 induces the development of monocytes into accessory cells, whereas D3 stimulates differentiation of monocytes into classical macrophages. These findings provide further evidence for the contention that, depending on defined stimuli, monocytes may develop either into accessory cells or into classical macrophages.     

脆性X综合征的遗传学诊断与产前诊断

脆性X综合征( fragile X syndrome,FraX )是一种常见的遗传性智力低下综合征,其发病率仅次于Down综合征,呈X连锁遗传,占X连锁智力低下的40%[1].1992年,Erster SH等报道其发病率男性为1/1250,女性约为1/2000;1997年,De Vries BB等报道其发病率男性为1/4000,女性为1/6000[2-3].发病率下降的原因可能是随着诊断技术的提高,减少误诊的结果.