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Wioletta Szczurek Mariusz Gsior Micha Skrzypek Boena Szygua‐Jurkiewicz 《American journal of transplantation》2020,20(10):2857-2866
Cardiac allograft vasculopathy (CAV) still is one of the most important limiting factors of long‐term survival following heart transplant (HT). This study aimed to investigate the association between proinflammatory adipokine‐visfatin and the incidence of CAV in HT recipients. After HT, 182 patients who had a follow‐up visit at the Transplantation Clinic between 2016 and 2017 were analyzed. The median age was 60.5 years, and 76.4% were men. The incidence of CAV was 54.9%. According to the multivariable proportional hazard regression analysis, visfatin level (1.795 [1.539‐2.094]; P < .001) was significantly associated with CAV, and statin use was protective against CAV (0.504 [0.32‐0.793]; P = .003). The area under the receiver operating characteristic curve indicated an excellent discriminatory power of visfatin (0.9548 [0.9281‐0.9816]) for CAV detection. The cutoff value of 5.42 ng/mL for visfatin yielded a sensitivity of 89% and specificity of 91%. This is the first study to demonstrate that visfatin serum concentrations are independently associated with the incidence of CAV in HT recipients. Visfatin allows for simple and cheap detection of CAV given its excellent discriminatory ability and high sensitivity and specificity. In addition, we have found an independent association between the statin use and a lower risk of CAV. 相似文献
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Agnieszka Sobczak-Kupiec Anna Drabczyk Wioletta Florkiewicz Magdalena Gb Sonia Kudacik-Kramarczyk Dagmara Sota Agnieszka Tomala Boena Tyliszczak 《Materials》2021,14(9)
Regenerative medicine is becoming a rapidly evolving technique in today’s biomedical progress scenario. Scientists around the world suggest the use of naturally synthesized biomaterials to repair and heal damaged cells. Hydroxyapatite (HAp) has the potential to replace drugs in biomedical engineering and regenerative drugs. HAp is easily biodegradable, biocompatible, and correlated with macromolecules, which facilitates their incorporation into inorganic materials. This review article provides extensive knowledge on HAp and collagen-containing compositions modified with drugs, bioactive components, metals, and selected nanoparticles. Such compositions consisting of HAp and collagen modified with various additives are used in a variety of biomedical applications such as bone tissue engineering, vascular transplantation, cartilage, and other implantable biomedical devices. 相似文献
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The study of the effect of cement type on the action of an admixture increasing the volume of concrete (containing aluminum powder), used in amounts of 0.5–1.5% of cement mass, was presented. The tests were carried out on cement mortars with Portland (CEM I) and ground granulated blast-furnace slag cement (CEM III). The following tests were carried out for the tested mortars: the air content in fresh mortars, compressive strength, flexural strength, increase in mortar volume, bulk density, pore structure evaluation (by the computer image analysis method) and changes in the concentration of OH− ions during the hydration of used cements. Differences in the action of the tested admixture depending on the cement used were found. To induce the expansion of CEM III mortars, a smaller amount of admixture is required than in the case of CEM I cement. Using the admixture in amounts above 1% of the cement mass causes cracks of mortars with CEM III cement due to slow hydrogen evolution, which occurs after mortar plasticity is lost. The use of an aluminum-containing admixture reduces the strength properties of the cement mortars, the effect being stronger in the case of CEM III cement. The influence of the sample molding time on the admixture action was also found. 相似文献
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Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1 总被引:2,自引:2,他引:2
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María del Mar lvarez‐Torres Javier Juan‐Albarracín Elies Fuster‐Garcia Fuensanta Bellvís‐Bataller David Lorente Gaspar Reyns Jaime Font de Mora Fernando Aparici‐Robles Carlos Botella Jose Muoz‐Langa Raquel Faubel Sabina Asensio‐Cuesta Germn A. García‐Ferrando Eduard Chelebian Cristina Auger Jose Pineda Alex Rovira Laura Oleaga Enrique Moll‐Olmos Antonio J. Revert Luaba Tshibanda Girolamo Crisi Kyrre E. Emblem Didier Martin Paulina Due‐Tnnessen Torstein R. Meling Silvano Filice Carlos Sez Juan M. García‐Gmez 《Journal of magnetic resonance imaging : JMRI》2020,51(5):1478-1486
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