基于网络药理学探讨红核妇洁洗液抗炎的活性成分和作用机制

目的 探索红核妇洁洗液抗炎的活性成分及作用机制,为红核妇洁洗液的临床应用提供科学依据.方法 通过SwissTargetPrediction基于结构相似性预测红核妇洁洗液中化合物的靶点,再与CTD和TCMSP数据库检索的靶点整合去重,得到红核妇洁洗液化学成分的靶蛋白或靶标基因,使用DisGeNET数据库进行炎症疾病靶点的...     

2011年至2012年988例门诊药品不良反应报告分析

目的：分析门诊患者药品不良反应（ARD）发生的规律及特点,促进临床合理安全用药。方法对医院2011年至2012年门诊药房收集的988例ADR报告进行回顾性统计和分析。结果988例ADR中,女性发生率（57.80%）明显高于男性（42.20%）;ADR涉及12类药物223个品种,发生率最高的为抗感染药物384例（43.32%）,其次为抗肿瘤药物128例（15.49%）和中药注射剂108例（13.87%）,临床主要表现为皮肤及其附件损害398例（40.28%）和消化系统损害242例（24.49%）。结论应重视ADR报告和监测工作,正确合理地应用药物,为临床合理用药提供参考。     

人工智能知识图谱和图像分类用于胸部后前位X线片质量控制

目的 观察人工智能(AI)知识图谱和图像分类对胸部后前位X线片(简称胸片)质量控制(QC)的价值。方法 回顾性分析安徽省影像云平台中595家医疗机构共9 236幅胸片,构建包含21个分类标签的QC知识图谱。先由10名技师据此对胸片进行2轮单人QC和1轮多人QC,分别将结果记为A、B、C;再以AI算法进行分类评估,将结果记为D。最后由1名QC专家对C、D进行审核并确定最终QC结果,以之为参考评估上述4种QC效果。结果 AI算法用于胸片QC的曲线下面积(AUC)均≥0.780,平均AUC为0.939。A、B、C、D胸片QC的平均精确率分别为81.15%、85.47%、91.65%、92.21%。结论 AI知识图谱和图像分类技术可有效用于胸部后前位X线片QC。     

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia

PurposeRetinal microglia promote angiogenesis and vasculopathy in oxygen-induced retinopathy (OIR); however, its specific molecular mechanism in the formation of retinal angiogenesis remains unclear. The lectin galactoside-binding soluble 3 binding protein (LGALS3BP), a member of the scavenger receptor cysteine-rich (SRCR) domain protein family, is involved in tumor neovascularization, and we therefore hypothesized that LGALS3BP plays an active role in microglia-induced angiogenesis.MethodsThe expression of LGALS3BP in microglia was detected by immunofluorescence, RT-qPCR, and western blotting. Functional assays of human umbilical vein endothelial cells (HUVECs) such as migration, proliferation, and tube formation were measured by Transwell, EdU, and Matrigel assays. Angiogenesis-related factors and PI3K/AKT levels were detected by western blotting. The relationship between LGALS3BP and PI3K or HIF-1α was investigated by immunoprecipitation.ResultsOur results showed that the expression of LGALS3BP was significantly increased in microglia surrounding neovascularization of the OIR mice and was also upregulated in human microglial clone 3 (HMC3) cells after hypoxia. Moreover, HUVECs co-cultured with hypoxic HMC3 cells showed increased migration, proliferation, and tube formation, as well as levels of angiogenesis-related factor. However, the proangiogenic ability and angiogenesis-related factor expression of HMC3 cells was suppressed after silencing LGALS3BP. LGALS3BP induces the upregulation of angiogenesis-related factors through the PI3K/AKT pathway and then promotes angiogenesis in microglia.ConclusionsCollectively, our findings suggest that LGALS3BP in microglia plays an important role in angiogenesis, suggesting a potential therapeutic target of LGALS3BP for angiogenesis.     

IgG4相关性肺疾病19例临床分析

目的 通过分析19例IgG4相关性肺疾病(IgG4-RLD)的临床特点,为临床医生对该病的早期诊治提供参考.方法 纳入2014年4月至2019年12月首次于四川大学华西医院就诊的19例IgG4-RLD患者作为研究对象,收集并分析其基本临床特征、实验室检查、影像学检查、组织病理学检查、治疗与随访结果等资料.结果 19例患...     

西药联合夏氏消癥汤治疗子宫肌瘤46例临床观察

目的 探讨西药联合夏氏消癥汤治疗子宫肌瘤的临床效果.方法 收集2019年1月至2020年3月黄河三门峡医院收治的88例子宫肌瘤患者的临床资料,将采用常规西药治疗的42例患者资料纳入对照组,将采用夏氏消癥汤联合常规西药治疗的46例患者资料纳入观察组.治疗3个月后,比较两组肌瘤体积、雌二醇(E2)水平、不良反应发生率.结果...     

术前预后营养指数对584例心脏手术后患者急性肾损伤的预测价值

目的 评估术前预后营养指数(prognostic nutritional index,PNI)对择期体外循环(cardiopulmonary bypass,CPB)下非冠状动脉旁路移植(coronary artery bypass grafting,CABG)心脏手术后急性肾损伤(acute kidney injury...     

阻塞性睡眠呼吸暂停低通气综合征患者听力学损害研究进展

阻塞性睡眠呼吸暂停低通气综合症(obstructive sleep apnea hypopnea syndrome,OSAHS)是一种常见的睡眠障碍性疾病,长期的呼吸暂停和低通气可引起不同程度的低氧血症及高碳酸血症,继发组织缺氧,最终导致多器官功能损害,其中包括第8对颅神经-听神经的损害.临床观察中也发现了部分OSAH...     

Analytical Model for Early Design Stage of Cable-Stayed Suspension Bridges Based on Hellinger–Reissner Variational Method

The cable-stayed suspension bridge is one type of bridge that has been increasingly applied to bridge engineering, especially in cross-sea projects. However, the complex combined system of this type of bridge makes it quite difficult for researchers to make a quick decision of the parameter values during the design stage. The Hellinger–Reissner method is applied here to analyze the deformation and force of the structural members in the bridge. The advantage of this method is that the solving of deformation and force is independent of each other, which would enhance the accuracy of the final results. Different load conditions are also considered in the analysis. The results from the present method are compared with test results and finite element analysis, and show good agreements. It implies that the Hellinger–Reissner is a comparatively more efficient method to help designers choose the key parameters for cable-stayed suspension bridges.