Restrictive effect of puerarin on myocardial infarct area in dogs and its possible mechanism

It has been known that puerarin can protectthe ischemic myocardia. Puerarin might achievesuch protection by decreasing heart rate and dilatelug vessels in the acute phase. A lot of studieshave been conducted on these mechanisms, but thelong--term mechanism was yet to be elucidated andthe effect of puerarin on coronary collateral circula.non was not reportedL" 2]. The purpose of thisstudy was to investigate the protection of puerarinon ischemic myocardia and the effect of puerarin oncoronary co…     

彩色多普勒组织显像在小儿病毒性心肌炎诊断中的应用

本文报告用彩色多普勒组织显像(DTI)测定正常小儿173名,病毒性心肌炎40例,发现DTI在正常小儿的规律。病毒性心肌炎二尖瓣环舒张早期运动速度(MVR-DeV)显著低于正常儿童,40例病毒性心肌炎MVR-DeV降低者占72.5％,经过治疗后MVR-DeV90％以上短期内恢复正常。MVR-DeV降低率显著高于心脏解剖、心功能、心脏血流参数、心电图和心肌酶的异常率。因此,MVR-DeV对病毒性心肌炎的诊断、病情了解以及疗效观察均有重要价值。     

正常成人嗓音频谱分析

为探讨不同性别及不同年龄阶段我国正常成人嗓音的声学特征,应用计算机频谱分析技术对145例18～80岁正常人的嗓音进行声学参数检测.结果表明:各年龄段男女基频(F_0),第二、三共振峰(F_2、F_3),频率微扰商(FPQ)以及中、青年男女间振幅微扰商(APQ)有显著性差异,男性振幅微扰商(APQ)随年龄增长而下降,六十岁以后又明显升高,老年男性基频(F_0)明显升高而老年女性基频(F_0)则明显下降.本研究可为临床嗓音的分析评估提供客观的方法和依据.     

嗓音频谱分析中／a／,／i／音采样的比较

应用486微型计算机和北京邮电大学通用信号谱分析系统分别对30例青年女性喉病患者和36例健康对照组的/a/、/i/音嗓音信号进行频谱分析,比较其相对信噪比,结论是在频谱分析中用/a/音采样较/i/音更易检出病态嗓音.     

先天性心脏病重度肺动脉高压性质的综合评价

目的探讨先天性心脏病（简称先心病）合并重度肺动脉高压患儿器质性肺动脉高压（简称肺高压）的诊断标准。方法３７例经手术治疗后早期肺动脉压力降至正常的患儿作为动力性肺高压组；７例经手术治疗后仍持续性肺动脉高压及６例临床诊断为器质性肺高压而未予手术的共１３例患儿作为器质性肺高压组，对比两组心导管检查血液动力学指标。结果两组肺血管阻力、肺小动脉楔压、肺循环血流量与体循环血流量之比（Ｑｐ／Ｑｓ）及降主动脉血氧饱和度（ＳａＯ２）差异均有显著意义，如按年龄大于２岁、肺动脉阻力＞７２ｋＰａ·ｓ－１·Ｌ－１（９Ｗｏｏｄ单位）、肺小动脉楔压≤１．６ｋＰａ（１２ｍｍＨｇ）、Ｑｐ／Ｑｓ＜２和动脉血氧饱和度＜０．９０作为临床诊断器质性肺高压的指标，则本组动力性肺高压组仅有５．４％的患儿符合上述指标３项或３项以上，而器质性肺高压组所有病例均符合上述指标３项或３项以上。结论先心病合并重度肺动脉高压存在上述５项指标中３项或３项以上，高度提示患儿存在器质性肺动脉高压     

三氧化二砷对神经母细胞瘤细胞增殖的影响

目的探讨三氧化二砷（Ａｓ２Ｏ３）对儿童神经母细胞瘤有无潜在的治疗价值及伍用细胞因子有无增强疗效的作用。方法应用四甲基偶氮唑蓝法于体外观察Ａｓ２Ｏ３对神经母细胞瘤细胞株ＳＪ－Ｎ－ＳＨ增殖的影响；并观察Ａｓ２Ｏ３伍用重组人γ－干扰素、肿瘤坏死因子、白细胞介素４、６、１０后的情况。结果０．５～４μｍｏｌ／Ｌ的三氧化二砷明显抑制ＳＪ－Ｎ－ＳＨ细胞的增殖，Ａｓ２Ｏ３伍用γ－干扰素、白细胞介素４可明显增强Ａｓ２Ｏ３对ＳＪ－Ｎ－ＳＨ细胞增殖的抑制，而其他几种细胞因子无明显作用。结论Ａｓ２Ｏ３为治疗神经母细胞瘤的有效药物，联合应用合适的细胞因子可增强Ａｓ２Ｏ３的疗效。     

癫痫儿童生活质量的研究

目的研究癫痫儿童的生活质量。方法应用美国癫痫生活质量量表，对１９２例癫痫儿童进行生活质量的评估，探讨影响因素并与正常儿童进行比较。结果癫痫儿童的生活质量明显低于正常儿童，主要表现在对发作的恐惧、长期用药的担忧、认知功能的障碍及社会交往的困难。即使发作已被控制，其生活质量并无明显改善。生活质量高低因发作类型不同而各异。结论对癫痫儿童应加强综合治疗，特别要进行心理干预，才能提高其生活质量。     

Unusual features in children with inv dup(15) supernumerary marker: a study of genotype-phenotype correlation in Taiwan

Recent molecular cytogenetic studies have elucidated the origin and nature of extra structurally abnormal chromosomes (ESACs) or small supernumerary chromosomes, which are often associated with developmental delay and malformations. We studied the prevalence of inv dup(15) in a nationwide screening programme for mentally retarded children in Taiwan and tried to correlate the genotype and phenotype in those patients. Fluorescence in situ hybridization (FISH) analysis using D15Z, D15Z1, and the cosmids from the Prader-Willi/Angelman syndrome chromosome region (PW/ASCR) was performed on 54 patients (0.45%) with ESACs from 11893 probands within a 5-year period. Of them, inv dup(15) was confirmed in 25 children (46.3%) by FISH analysis. The PW/ASCR probes were used to clarify the size and DNA composition of the markers. Patients with inv dup(15) chromosomes, containing only the heterochromatin or little euchromatin of the proximal 15q (i.e., pter→q11:q11→pter) may have a rather mild or nearly normal phenotype (group 1). Only one patient had some features suggestive of Angelman syndrome, but was considered to be a result of deleted (15)(q12) in the chromosome 15 homologue. Additional copies within D15S11 through GABRB3 (15q11.2-13) resulted in an abnormal phenotype which involved mental and developmental delay but was different from the classical phenotype of PW/AS (groups 2, 3). Signs of autistic behavior did occur in each group. FISH combined with microsatellite analyses showed that the marker was often of maternal origin in de novo cases (n = 12, 86%), or inherited from the mother in only one familial case. Down-inv dup(15) was mentioned in two cases. Unusual features including diaphragmatic eventration, hyperlaxity of joints, arachnodactyly, brain atrophy, epilepsy (particularly infantile spasm), ataxia, genital abnormalities, and cleft lip/palate were noted in those patients. This observation expands the range of phenotypic expression associated with this relatively common ESAC. Conclusion Marked phenotypic diversities exist in children with inv dup(15), dependent upon the size or genetic composition of the markers, degree of mosaicism, parental origin and familial occurrence or not. Patients with a larger inv dup(15) marker chromosome including the PW/ASCR may have a higher risk of abnormalities, but not the typical Prade-Willi/Angelman syndrome phenotype. Received: 11 February 1997 and in revised form: 20 May 1997 / Accepted: 20 May 1997     

上颌骨掀翻复位术在良性涉颅鼻腔鼻窦肿瘤中的应用

目的探讨涉颅良性鼻腔、鼻窦肿瘤的手术治疗方法。方法报道６例鼻腔、鼻窦良性肿瘤侵及颅底的病例，其中骨化纤维瘤３例，骨瘤１例，骨软骨瘤１例，骨巨细胞瘤（Ｉ～Ｉ级）１例，均采用１侧上颌骨掀翻复位术及颅面联合进路手术切除肿瘤，全部切除肿瘤４例，近次全切除２例。结果无手术并发症，术后随访２～３年，５例无异常，１例骨化纤维瘤术后２年复发。结论上颌骨掀翻术是一种较好的治疗涉颅良性鼻腔、鼻窦肿瘤的手术方法。     

Evaluation of the effectiveness of preoperative embolization in surgery for nasopharyngeal angiofibroma

We retrospectively analyzed the clinical data of 21 patients (22 procedures) with histologically proven nasopharyngeal angiofibromas. Eleven patients underwent preoperative intra-arterial digital subtraction angiography (IADSA) and embolization with Gelfoam. Embolization reduced the intraoperative blood loss from an average of 1136 ml in the non-embolized patients to 677 ml in the embolized cases (P < 0.05) and transfusions from an average of 836 ml to 400 ml (P < 0.01). Results again show that preoperative embolization is effective in reducing intraoperative blood loss. Received: 10 May 1997 / Accepted: 21 October 1997