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41.
Disease laterality,eye dominance,and visual handicap in patients with unilateral full thickness macular holes 下载免费PDF全文
AIM: To investigate the association between visual handicap, laterality, and historical eye dominance in patients presenting with unilateral full thickness macular holes (FTMH). METHODS: Consecutive patients presenting with unilateral FTMH and no other visually significant ocular pathology including abnormalities of binocular vision were included. A questionnaire and case note review were performed to determine the mode of presentation, presence of symptomatic binocular interference, historically dominant eye, and whether they elected to undergo surgery. RESULTS: 44 eyes of 44 patients fulfilled the inclusion criteria. 21 (48%) affected eyes were right sided and 56% of FTMH were in the historically dominant eye. 76% of FTMH in historically dominant eyes presented symptomatically compared to 36% in non-dominant eyes (p= 0.003). 72% of patients with FTMH affecting their historically dominant eye were aware of binocular interference in day to day binocular viewing compared with 21% when the FTMH was in the non-dominant eye (p= 0.001). 23 (52%) patients elected to undergo surgery, of whom 18/23(78%) had FTMH in their historically dominant eye (p= 0.0003). CONCLUSION: This study suggests that eye dominance may be an important determinant of the visual handicap suffered by patients with unilateral FTMH. 相似文献
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To determine the baseline environmental radiation and resulting population exposure, natural background levels at the King Saud University campus were measured using CaSO4:Dy (TLD-900) discs. Measurements were made 1 m above ground level at 10 locations. Two different calculational methods were utilized to account for signal fading. In the first method, a fading correction factor was determined and used separately. In the second method, a separate correction factor for fading was not required because the determined calibration factor was carrying this correction. Results of the two methods were similar. Measurements were performed on a quarterly basis for a 2-y period (January 1988 to December 1989). The annual average dose rate was 565.4 +/- 27.1 mu Gy y-1 in air. 相似文献
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Luísa S.M. Mendonça Rhianon Perrott-Reynolds Roy Schwartz Haifa A. Madi Nicola Cronbach Isaac Gendelman Alyson Muldrew Finnian Bannon Konstantinos Balaskas Chui Ming Gemmy Cheung Amani Fawzi Daniela Ferrara K. Bailey Freund James Fujimoto Marion R. Munk Giuseppe Querques Ramiro Ribeiro Philip J. Rosenfeld Nadia K. Waheed 《Ophthalmology》2021,128(7):1109-1112
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Studies were undertaken to examine the role of colony-stimulating factor (CSF) in controlling murine peritoneal diffusion-chamber (DC) granulopoiesis. Serum CSF was unchanged for 1-3 days after 700-750 rad total body irradiation. Variable increments were noted on the fourth and seventh days after irradiation. DC CSF increased four- to fivefold over serum activity within 24 h of implantation in control mice. An eight- to tenfold increment over serum levels was noted in DC CSF from irradiated mice. Both serum and DC CSF were neutralized completely by repeated injections of anti-CSF serum. DC granulopoiesis was studied by immobilizing marrow cells in plasma clots in peritoneal DC. Repetitive administration of anti-CSF serum or a purified monospecific anti-CSF antibody caused a marked reduction in DC granulopoiesis. This was characterized by a decrease in both the number and size of granulocyte colonies, with a 40%-80% decrease in total granulocytes per chamber. These findings indicate that the granulopoiesis observed in the DC of irradiated hosts is associated with an increase in local rather than systemic CSF production. Neutralization of the CSF reduces proliferation of the granulocyte progenitor cell and maturation of more differentiated granulocytic cells. 相似文献
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Elisabetta Miserocchi MD Nadia K. Waheed MD Stefanos Baltatzis MD C. Stephen Foster MD FACS 《American journal of ophthalmology》2001,132(6):923-924
PURPOSE: To describe a case of chronic cicatrizing conjunctivitis in a patient with ocular cicatricial pemphigoid and Wegener granulomatosis. METHODS: Observational case report. A retrospective study. RESULTS: An 80-year-old man presented with chronic cicatrizing conjunctivitis, peripheral corneal thinning, and Wegener granulomatosis, which were diagnosed by his referring physician based on clinical (recurrent epistaxis, sinus congestion) and histopathologic features of nasal mucosa (granulomatous inflammation, vasculitis). A conjunctival biopsy performed by us disclosed features of active Wegener granulomatosis and ocular cicatricial pemphigoid, which indicate lack of control of both diseases with methotrexate treatment. The patient died of pulmonary complications from Wegener granulomatosis 1 week after our evaluation. CONCLUSION: Ocular cicatricial pemphigoid and Wegener granulomatosis are both potentially fatal autoimmune diseases. Ocular involvement in Wegener granulomatosis indicates poor control of the underlying systemic condition and is a marker for active vasculitis, which indicates the need for treatment with cyclophosphamide. 相似文献
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Abdul Waheed 《Anatomy and embryology》1936,106(4):558-574
Ohne ZusammenfassungMit 10 Textabbildungen.Dissertation der medizinischen Fakultät der Universität Zürich. 相似文献
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Raja Amjad Waheed Khan Jianhua Chen Meng Wang Zujia Wen Jiawei Shen Zhijian Song 《The world journal of biological psychiatry》2016,17(2):140-146
Objectives The SLCO6A1 gene belongs to a superfamily of genes which is known to be a solute carrier family of OATPs (SLCO). The SLCO6A1 gene encodes OATP6A1 protein in humans. A previous genome-wide association study (GWAS) of schizophrenia conducted in the Swedish population demonstrated a significant association of rs6878284, which is located in the SLCO6A1 gene, with schizophrenia. To further investigate whether this gene is also a risk locus for schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD) in the Han Chinese population, a case–control study was designed. Methods In total 1,248 unrelated SCZ cases, 1,344 BPD cases, 1,056 unrelated MDD cases and 1,248 normal controls were analysed in this study. We genotyped five SNPs using the Sequenom MassARRAY platform. Results We found no association of rs6878284 with SCZ [Corrected Pallele?=?0.969, Corrected Pgenotype?=?0.997]. Furthermore, we found a statistically significant association of the rs7734060 genotype with MDD after correction [rs7734060: Corrected Pallele?=?0.114, Corrected Pgenotype?=?0.036] in the Han Chinese population. Conclusions This is the first study which reveals no association of rs6878284 with SCZ and also predicts that rs7734060 could be a risk locus for MDD in the Han Chinese population. 相似文献