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81.
Heterologous production of albicidin: a promising approach to overproducing and characterizing this potent inhibitor of DNA gyrase 下载免费PDF全文
Vivien E Pitorre D Cociancich S Pieretti I Gabriel DW Rott PC Royer M 《Antimicrobial agents and chemotherapy》2007,51(4):1549-1552
The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction. 相似文献
82.
Griffiths V 《Nursing standard (Royal College of Nursing (Great Britain) : 1987)》2007,22(11):48-57; quiz 58
Midline catheters are commonly inserted by nurses to make short and long-term infusion of intravenous fluids and medication easier. This article provides an overview of the value of these devices in adult nursing. It also describes the history and management of the midline catheter in relation to current research and evidence-based practice. 相似文献
83.
Kwek Jia Liang Griva Konstadina Kaur Navreen Chong Kay Yuan Chua Zi Yang Sim Gim Hong Andy Ng Li Choo Yong Pay Wen Tung Yu-Tzu Lim Lydia Wei Wei Teo Su Hooi Choo Jason Chon Jun Foo Marjorie Wai Yin Jafar Tazeen Hasan 《International urology and nephrology》2022,54(4):917-926
International Urology and Nephrology - This study aimed at determining the feasibility of conducting a large-scale pragmatic effectiveness study on the implementation of multidisciplinary care... 相似文献
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Chan Gek Cher Ho Peh Joo Li Jialiang Lee Evan Jon Choon Chua Horng Ruey Lau Titus Sethi Sunil Teo Boon Wee 《International urology and nephrology》2020,52(3):533-540
International Urology and Nephrology - Plasma galectin-3 (pG3) regulates inflammation. B-type natriuretic peptide (BNP), high-sensitivity Troponin I (hsTnI), and pG3 concentrations are elevated in... 相似文献
86.
Jeffrey J. Leow Vanessa W. Lim Pravin Lingam Karen T. S. Go Li Tserng Teo 《World journal of surgery》2014,38(7):1694-1698
Background
Ethnic disparities in trauma mortality outcomes have been demonstrated in the United States according to the US National Trauma Data Bank. The aim of this study was to determine the effect of race/ethnicity on trauma mortality in Singapore.Methods
This was a retrospective review of patients aged 18–64 years with an injury severity score (ISS) ≥9 in the Trauma Registry of Tan Tock Seng Hospital, a 1,300-bed trauma center in Singapore, from 2006 to 2010. Chinese, Malay, and Indian patients were compared with patients of other ethnic groups. Multiple logistic regression analyses determined differences in survival rates after adjusting for demographics, anatomic and physiologic ISS and revised trauma score, mechanism or type of injury.Results
A total of 4,186 patients (66.4 % of the database) met the inclusion criteria. Most patients were male (76.3 %) and young (mean age 40 years). Using Chinese as the reference group, we found no statistically significant differences in unadjusted or adjusted mortality rates among the ethnic groups. Independent predictors of mortality included age [odds ratio (OR) 1.05, 95 % confidence interval (CI) 1.03–1.06, p < 0.0001], presence of severe head injury (OR 1.75, 95 % CI 1.13–2.69, p = 0.012), and increasing ISS (p < 0.0001).Conclusions
Ethnicity is not an independent predictor of trauma mortality outcomes in the Singapore population. Our findings contrast with those from the United States, where race/ethnicity (Black and Hispanic) remains a strong independent risk factor for trauma mortality. This study attests to the success of the Singapore health care/trauma system in delivering the same quality of care regardless of ethnicity. 相似文献87.
Hideaki Matsubayashi Michiaki Nagai Keigo Dote Yuda Turana Saulat Siddique YookChin Chia ChenHuan Chen HaoMin Cheng Huynh Van Minh Narsingh Verma Jam Chin Tay Boon Wee Teo Kazuomi Kario 《Journal of clinical hypertension (Greenwich, Conn.)》2021,23(3):496
Although short and long sleep duration are both risk factors of cardiovascular disease (CVD), the recent meta‐analyses have been shown that long sleep duration was closely associated with CVD mortality. While the specific mechanism underlying the association between long sleep duration and CVD remains unclear, long sleep duration was shown to be associated with arterial stiffness and blood pressure variability (BPV) in many Asian populations. This review article will focus on the pathophysiology of long sleep duration, arterial stiffness, BPV and their effects on CVD. To set the stage for this review, we first summarize the current insights for the relationship between long sleep duration and CVD in relation to arterial stiffness and BPV. 相似文献
88.
TzungDau Wang ChihKuo Lee YookChin Chia Kelvin Tsoi Peera Buranakitjaroen ChenHuan Chen HaoMin Cheng Jam Chin Tay Boon Wee Teo Yuda Turana Guru Prasad Sogunuru JiGuang Wang Kazuomi Kario the HOPE Asia Network 《Journal of clinical hypertension (Greenwich, Conn.)》2021,23(3):481
The prevalence of erectile dysfunction (ED) is above 40% in both Asian and non‐Asian male populations after the age of 40 years. The prevalence of ED among hypertensive patients is approximately double than that in normotensive population. Pelvic arterial insufficiency is the predominant cause of ED in men aged over 50 years. Stenosis in any segment of the iliac–pudendal–penile arterial system, which is considered an erectile‐related arterial axis, could lead to ED. Pharmacotherapy with lifestyle modification is effective in alleviating sexual dysfunction, yet a substantial number of patients still develop ED. Given the established applicability of angioplasty for the entire iliac–pudendal–penile arterial system, penile duplex ultrasound, and pelvic computed tomography angiography could be considered as the routine screening tools in ED patients with poor response to phosphodiesterase‐5 inhibitors. Endovascular therapy for pelvic arterial insufficiency‐related ED has been shown to be a safe and effective treatment option in patients who have anatomically suitable vessels and functionally significant stenoses. Clinical improvement was achieved in over 60% of patients at one year following pelvic angioplasty in the PERFECT registry from Taiwan. A 30%‐40% restenosis rate in distal internal pudendal and penile arteries remains a hurdle. Angioplasty for pelvic arterial occlusive disease could be considered as a viable approach to arteriogenic ED. 相似文献
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Evan Foster B.Sc. Julia E. Fraser Elizabeth L. Inness PhD Sarah Munce Louis Biasin Vivien Poon 《Physiotherapy theory and practice》2019,35(8):787-796
Objective: To determine the frequency of physiotherapist-administered aerobic exercise testing/training, the proportion of physiotherapists who administer this testing/training, and the barriers that currently exist across different practice environments. A secondary objective is to identify the learning needs of physiotherapists for the development of an education curriculum in aerobic exercise testing and training with electrocardiograph (ECG) administration and interpretation. Design: National, cross-sectional survey. Participants: Registered physiotherapists practicing in Canada. Results: Out of 137 participants, most (75%) physiotherapists prescribed aerobic exercise on a regular basis (weekly); however, 65% had never conducted an aerobic exercise test. There were no significant differences in frequency of aerobic exercise testing across different practice environments or across years of physiotherapy experience. Physiotherapists perceived the main barriers to aerobic exercise testing as being a lack of equipment/space (78%), time (65%), and knowledge (56%). Although most (82%) were uncomfortable administering 12-lead ECG-monitored aerobic exercise tests, 60% stated they would be interested in learning more about ECG interpretation. Conclusion: This study found that physiotherapists are regularly implementing aerobic exercise. This exercise was infrequently guided by formal aerobic exercise testing, which could increase access to safe and effective exercise within the optimal aerobic training zone. As well, this could facilitate training in patients with cardiovascular diagnoses that require additional testing for medical clearance. Increased ECG training and access to equipment for physiotherapists may augment pre-screening aerobic exercise testing. This training should include learning the key arrhythmias for aerobic exercise test termination as defined by the American College of Sports Medicine. 相似文献