Ueber den wirksamen Bestandtheil der Adonis vernalis L.

Ohne Zusammenfassung     

Akute tödliche Vergiftung durch Askaridol

Ohne Zusammenfassung     

Der Einfluß der Röntgenstrahlen auf den Cholesteringehalt des Blutes von Carcinomkranken

Ohne ZusammenfassungMit 1 Textabbildung     

Serologische Untersuchungen an Arbeitern in überhitzten Räumen

Zusammenfassung Zusammenfassend glauben wir folgendes feststellen zu können: Bei gesunden, unter verschiedenen Bedingungen arbeitenden Menschen erscheint das gesamtehämolytische Vermögen des Serums merklich herabgesetzt. Wir sind der Ansicht, daß dies von einer Erschwerung der Agglutination der Erythrocyten zum Zwecke ihrer nachfolgenden Zerstörung abhängt, einer Fähigkeit, die dem Amboceptor zugeschrieben wird.Eine solche Auslegung wird noch bestätigt durch die Feststellung, daß dasKomplement, mithin das lytische Hämolysin, bei denselben Personen unverändert bleibt.Das Serum weist unter denselben Bedingungen ein ausgesprochenes komplementbindendes (antikomplementäres) Vermögen auf.Diese Feststellungen veranlassen uns zu dem Schluß, daß einige der Abwehrkräfte des Organismus, mittels welcher er sich gewöhnlich gegen schädliche Einflüsse schützt, bei Menschen, die in überhitzten Räumen arbeiten, deutliche Veränderungen erleiden.     

Prexasertib,a checkpoint kinase inhibitor: from preclinical data to clinical development

Cancer Chemotherapy and Pharmacology - Checkpoint kinases 1 and 2 (CHK1 and CHK2) are important multifunctional proteins of the kinase family. Their main function is to regulate DNA replication and...     

The Performance of Graphene-Enhanced THz Grating: Impact of the Gold Layer Imperfectness

We report the performance of a graphene-enhanced THz grating fabricated by depositing a gold layer on the femtosecond micromachined SiO₂ substrate. The morphology of the gold plated patterned substrate was studied by scanning electron microscopy (SEM) and atomic force microscopy (AFM), while the quality of the chemical vapor deposition (CVD) graphene was evaluated by Raman spectroscopy. The electromagnetic (EM) response of the metasurface comprising the graphene sheet and the gold plated substrate was studied by THz time domain spectroscopy in the 100 GHz–1 THz frequency range. We employed the finite elements method (FEM) to model the metasurface EM response by adjusting the ac conductivity of the gold layer covering the patterned SiO₂ substrate to reproduce the measured transmission/reflection spectra. The results of the numerical simulation reveal the impact of the imperfectness of the gold layer on the performance of the THz metasurface. The experimental results are well described in terms of the Drude–Smith model of metal conductivity that takes into account the anisotropic scattering of the carriers in thin metal films.     

Electrochemical Synthesis of Zinc Oxide Nanostructures on Flexible Substrate and Application as an Electrochemical Immunoglobulin-G Immunosensor

Immunoglobulin G (IgG), a type of antibody, represents approximately 75% of serum antibodies in humans, and is the most common type of antibody found in blood circulation. Consequently, the development of simple, fast and reliable systems for IgG detection, which can be achieved using electrochemical sandwich-type immunosensors, is of considerable interest. In this study we have developed an immunosensor for human (H)-IgG using an inexpensive and very simple fabrication method based on ZnO nanorods (NRs) obtained through the electrodeposition of ZnO. The ZnO NRs were treated by electrodepositing a layer of reduced graphene oxide (rGO) to ensure an easy immobilization of the antibodies. On Indium Tin Oxide supported on Polyethylene Terephthalate/ZnO NRs/rGO substrate, the sandwich configuration of the immunosensor was built through different incubation steps, which were all optimized. The immunosensor is electrochemically active thanks to the presence of gold nanoparticles tagging the secondary antibody. The immunosensor was used to measure the current density of the hydrogen development reaction which is indirectly linked to the concentration of H-IgG. In this way the calibration curve was constructed obtaining a logarithmic linear range of 10–1000 ng/mL with a detection limit of few ng/mL and good sensitivity.