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81.
Jedas Veronica Daag Michelle Ylade Cameron Adams Ramesh Jadi Maria Vinna Crisostomo Riacarl Alpay Emma Teresa Carmela Aportadera In-Kyu Yoon Laura White Jacqueline Deen Aravinda M. de Silva Anna Lena Lopez 《Clinical microbiology and infection》2021,27(6):904-908
ObjectiveVaccination with the first licensed dengue vaccine is recommended only for those who have had previous infection with dengue virus (DENV). A point-of-care test with the desired sensitivity of 95% and specificity of 98% could facilitate pre-vaccination screening. We evaluated a newly developed, automated dengue immunoglobulin fluorescence immunoassay for determining dengue serostatus.MethodsWe used serum samples collected just prior to a mass dengue vaccination in Cebu, Philippines. Healthy children residing in Bogo and Balamban who would be 9–14 years old at the time of the mass dengue vaccination were eligible to participate. We evaluated the ichroma? II dengue fluorescence immunoassay (Boditech Med Incorporated, Gang-won-do, Republic of Korea) using a neutralization test (NT) as the reference assay.ResultsWe enrolled 2996 children (mean age 10.39 years, 51.7% female) in the cohort and included a subsample of 1000 (mean age 10.56 years, 54.4% female) in this study. Of the 1000 children, 86/1000 (8.6%) tested seronegative and 914/1000 (91.4%) seropositive for DENV antibodies by neutralization testing. Compared with the NT, the dengue IgG fluorescence immunoassay had an overall specificity of 90.7% (95%CI: 82.5–95.9%) and a sensitivity of 91.8% (95%CI: 89.8–93.5%) for determining dengue seropositivity. The sensitivity declined to 51.2% (42.3–61.0%) for the detection of the subset with a monotypic dengue profile.ConclusionThe insufficient specificity and sensitivity (particularly in the detection of a previous monotypic dengue infection) would render the test, in its current state, inadequate for pre-vaccination screening. Considering its user-friendly interphase and possibility of point-of-care use, the test could be further developed and validated to improve its performance characteristics. 相似文献
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Kawasaki disease and giant coronary artery aneurysms: the role of echocardiography from diagnosis through follow‐up 下载免费PDF全文
Adam C. Adler M.D. M.S. Ramesh Kodavatiganti M.D. 《Echocardiography (Mount Kisco, N.Y.)》2016,33(8):1245-1250
Kawasaki disease is an acquired vasculitis that can affect the coronary arteries placing the patient at risk for coronary artery thrombosis, myocardial ischemia and infarction. The risk of complications related to coronary artery involvement persists for years despite recovery from the acute illness phase. The risk of late coronary disease progression necessitates long term follow‐up generally accomplished by non‐invasive echocardiography in pediatric patients. We review the utility of echocardiography in patients with Kawasaki disease as it relates to initial management, risk stratification and follow‐up of these children. 相似文献
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Endoscopic ultrasonography is not required for staging malignant esophageal strictures that preclude the passage of a diagnostic gastroscope 下载免费PDF全文
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Ramesh Kumar Sharma 《Indian Journal of Plastic Surgery》2013,46(2):167-Aug;46(2):167
86.
Pappu Ramesh Jabbour Serge A. Reginato Anthony M. Reginato Antonio J. 《Clinical rheumatology》2017,36(3):735-735
Clinical Rheumatology - 相似文献
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