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991.
Postoperative iodine‐125 interstitial brachytherapy for the early stages of minor salivary gland carcinomas of the lip and buccal mucosa with positive or close margins 下载免费PDF全文
992.
Background: We evaluated the safety and feasibility of performing a laparoscopic intracorporeal end-toside small bowel anastomosis
using a stapling technique as part of a Roux-en-Y gastric bypass operation (RYGBP). Methods: 80 consecutive patients who underwent
RYGBP with laparoscopic jejunojejunostomy were evaluated. Operative time and intraoperative and postoperative complications
directly related to the jejunojejunostomy anastomosis were recorded. Results: All 80 laparoscopic jejunojejunostomy procedures
were successfully performed without conversion to laparotomy. Mean operative time was longer for the first 40 laparoscopic
RYGBP than for the last 40 RYGBP (32±18 min vs 21±14 min, respectively, p<0.05). Intraoperative complications were staple-line
bleeding (2 patients) and narrowing of the anastomosis (1 patient). Postoperative complications were four small bowel obstructions:
technical narrowing at jejunojejunostomy site (2 patients), angulation of the afferent limb (1 patient), and food impaction
at the jejunojejunostomy anastomosis (1 patient). These four patients underwent successful laparoscopic re-exploration and
creation of another jejunojejunostomy proximal to the original anastomosis. There were no small bowel anastomotic leaks. The
median time to resuming oral diet was 2 days. Conclusions: Laparoscopic jejunojejunostomy as part of the RYGBP operation is
a safe and technically feasible procedure. Postoperative small bowel obstruction is a potential complication, which can be
prevented by avoiding technical narrowing of the afferent limb. 相似文献
993.
994.
Hiromichi Niida MA Dr. Koji Takeuchi PhD Koji Ueshima BS Susumu Okabe PhD 《Digestive diseases and sciences》1991,36(4):441-448
The pathophysiological changes associated with hypothermia were investigated in the rat stomach under anesthetized conditions. The animal was placed in a styrene foam box and the core body temperature was kept between 24 and 36°C using a heat lamp and refrigerant pack. Lowering of body temperature (<30°C) produced acid hypersecretion and induced hemorrhagic lesions in the gastric mucosa; these responses reached the maximum at 28°C, and a significant relationship was found between acid output and lesion score. Hypothermia (28°C) also caused a marked increase of gastric contractile activity and mucosal blood flow (MBF), but the ratio of acid output to MBF became greater when compared to that obtained under normothermic conditions. These changes induced by hypothermia (28°C) were completely blocked by vagotomy and were significantly inhibited by atropine, hexamethonium, clonidine, or TRH antiserum. However, lowering body temperature did not significantly affect acid secretory, motility, and ulcerogenic responses induced by carbachol in the vagotomized rat, excluding local mechanisms (suppression of the inhibitory nerves) in the hypothermia-induced changes. We conclude that hypothermia alone stimulates vagally dependent acid secretion and motility, resulting in damage in the gastric mucosa. These changes may be centrally mediated by TRH, which is released in association with the thermogenic response to hypothermia. 相似文献
995.
Kunihiko Tominaga MD Dr Ph John H. Kurata PhD Dr. Yang K. Chen MD Edward Fujimoto DHSc MPH Shouhei Miyagawa Ichiro Abe MSA Yoshimasa Kusano BS 《Digestive diseases and sciences》1995,40(9):2002-2009
The prevalence of fatty liver in children is unknown and its relationship to obesity is poorly defined. The present study of 810 northern Japanese children (4–12 years old) determined the prevalence of fatty liver in the pediatric population and its relationship to obesity. Diagnosis of fatty liver was based on established real-time ultrasonographic criteria. The overall prevalence of fatty liver was 2.6% and was higher for boys (3.4%) than for girls (1.8%), although not statistically significant (P=0.15). Fatty liver was found in children as young as 6 years of age. There was no significant association between the prevalence of fatty liver and height (physical growth). There was a strong positive correlation between fatty liver prevalence and established obesity indices: Rohrer's index-2 linear trend =59.2,P<0.0001; body mass index-2 linear trend =91.6,P<0.0001; and age-gender-adjusted Japanese standard index of weight for height-2 linear trend =93.2,P<0.0001. However, direct measurement of abdominal subcutaneous fat thickness by ultrasonography was the best predictor of fatty liver: 2 linear trend =159,P<0.0001. These results indicate that fatty liver may develop very early in life, and there is a direct relationship between degree of obesity and fatty liver in children. 相似文献
996.
Vaughan DE 《Journal of thrombosis and thrombolysis》1995,2(3):187-193
Plasminogen activator inhibitor-1 (PAI-1) is the major physiologic inhibitor of plasminogen activation in plasma and in the blood vessel wall. PAI-1 exhibits distinctive structural and functional properties that have been extensively studied over the past decade. Aside from the physiological role of PAI-1, there is accumulating evidence that increased production of PAI-1 may contribute to the development of ischemic cardiovascular disease. Efforts are now underway to develop and test specific inhibitors of PAI-1. 相似文献
997.
José R. Banegas MD Julián Segura MD Alejandro de la Sierra MD Manuel Gorostidi MD Fernando Rodríguez-Artalejo MD Javier Sobrino MD Juan J. de la Cruz BS Ernest Vinyoles MD Raquel Hernández del Rey MD Auxiliadora Graciani MD Luis M. Ruilope MD Spanish Society of Hypertension ABPM Registry Investigators 《The American journal of medicine》2008,121(12):1078-1084
Background
Gender differences in hypertension control have not been explored fully.Methods
We studied 15,212 white men and 13,936 white women with treated hypertension who were drawn from the Spanish Ambulatory Blood Pressure Registry. For each participant, we obtained office blood pressure (BP) (average of 2 readings) and 24-hour ambulatory BP (average of measurements performed every 20 minutes during day and night).Results
Only 16.4% of women and 14.7% of men had both office (<140/90 mm Hg) and ambulatory (<130/80 mm Hg) BP controlled (P < .001). Women had a lower frequency of masked hypertension (office BP < 140/90 mm Hg and ambulatory BP ≥ 130/80 mm Hg) than men (5.9% vs 7.9%, P < .001). Women had a higher frequency of isolated office hypertension (office BP ≥ 140/90 mm Hg and ambulatory BP < 130/80 mm Hg) (32.5% vs 24.2%, P < .001). Although office BP control (office BP < 140/90 mm Hg, regardless of ambulatory values) was similar in women and men (22.3% vs 22.6%, P = .542), ambulatory BP control (ambulatory BP < 130/80 mm Hg, regardless of office values) was higher in women than in men (48.9% vs 38.9%, P < .001). After adjustment for age, number of antihypertensive drugs, hypertension duration, and risk factors, gender differences in BP control remained practically unchanged.Conclusion
Ambulatory BP control was higher in women than in men. This may be due to the higher frequency of isolated office hypertension in women, and it is not explained by gender differences in other important clinical characteristics. 相似文献998.
999.
Tiffani J. Mungoven Kasia K. Marciszewski Vaughan G. Macefield Paul M. Macey Luke A. Henderson Noemi Meylakh 《The journal of headache and pain》2022,23(1)
BackgroundThe precise underlying mechanisms of migraine remain unknown. Although we have previously shown acute orofacial pain evoked changes within the brainstem of individuals with migraine, we do not know if these brainstem alterations are driven by changes in higher cortical regions. The aim of this investigation is to extend our previous investigation to determine if higher brain centers display altered activation patterns and connectivity in migraineurs during acute orofacial noxious stimuli.MethodsFunctional magnetic resonance imaging was performed in 29 healthy controls and 25 migraineurs during the interictal and immediately (within 24-h) prior to migraine phases. We assessed activation of higher cortical areas during noxious orofacial heat stimulation using a thermode device and assessed whole scan and pain-related changes in connectivity.ResultsDespite similar overall pain intensity ratings between all three groups, migraineurs in the group immediately prior to migraine displayed greater activation of the ipsilateral nucleus accumbens, the contralateral ventrolateral prefrontal cortex and two clusters in the dorsolateral prefrontal cortex (dlPFC). Reduced whole scan dlPFC [Z + 44] connectivity with cortical/subcortical and brainstem regions involved in pain modulation such as the putamen and primary motor cortex was demonstrated in migraineurs. Pain-related changes in connectivity of the dlPFC and the hypothalamus immediately prior to migraine was also found to be reduced with brainstem pain modulatory areas such as the rostral ventromedial medulla and dorsolateral pons.ConclusionsThese data reveal that the modulation of brainstem pain modulatory areas by higher cortical regions may be aberrant during pain and these alterations in this descending pain modulatory pathway manifests exclusively prior to the development of a migraine attack. 相似文献
1000.