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21.
Burkholderia pseudomallei in Environment of Adolescent Siblings with Melioidosis,Kerala, India, 2019
Praveena Bhaskaran Vinitha Prasad Anusha Gopinathan Tushar Shaw Suchitra Sivadas Chandrasekhar Jayakumar Soumi Chowdhury Aparna Dravid Chiranjay Mukhopadhyay Anil Kumar 《Emerging infectious diseases》2022,28(6):1246
In 2019, Burkholderia pseudomallei was isolated from the backyard of 2 siblings with melioidosis in Kerala, India. This finding highlights the value of healthcare providers being aware of risk for melioidosis in febrile patients, of residents taking precautions when outside, and of increasing environmental surveillance for B. pseudomallei in this region. 相似文献
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Introduction Benign mucinous cystadenomas account for 15% of all ovarian neoplasms and up to 80% of all mucinous tumors. Laparoscopy has
become an accepted method of management for ovarian cysts and its role is expanding as large benign adnexal masses more than
10 cm can be managed safely and effectively.
Case report We report a 25-year-old nulliparous lady with a huge benign mucinous cystadenoma managed by laparoscopic cystectomy, followed
by an early recurrence within 2 months. Left salpingo-oophorectomy was performed on a repeat laparoscopy due to suspicion
of malignancy on ultrasound. Pathology revealed a benign cyst.
Conclusion Since mucinous tumors are usually benign and multilocular, management of young patients is challenging, especially in the
case of recurrence which is very rare. 相似文献
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Joseph Driver Samantha E Hoffman Sherwin Tavakol Eleanor Woodward Eduardo A Maury Varun Bhave Noah F Greenwald Farshad Nassiri Kenneth Aldape Gelareh Zadeh Abrar Choudhury Harish N Vasudevan Stephen T Magill David R Raleigh Malak Abedalthagafi Ayal A Aizer Brian M Alexander Keith L Ligon David A Reardon Patrick Y Wen Ossama Al-Mefty Azra H Ligon Adrian M Dubuc Rameen Beroukhim Elizabeth B Claus Ian F Dunn Sandro Santagata Wenya Linda Bi 《Neuro-oncology》2022,24(5):796
BackgroundMeningiomas are the most common primary intracranial tumor in adults. Clinical care is currently guided by the World Health Organization (WHO) grade assigned to meningiomas, a 3-tiered grading system based on histopathology features, as well as extent of surgical resection. Clinical behavior, however, often fails to conform to the WHO grade. Additional prognostic information is needed to optimize patient management.MethodsWe evaluated whether chromosomal copy-number data improved prediction of time-to-recurrence for patients with meningioma who were treated with surgery, relative to the WHO schema. The models were developed using Cox proportional hazards, random survival forest, and gradient boosting in a discovery cohort of 527 meningioma patients and validated in 2 independent cohorts of 172 meningioma patients characterized by orthogonal genomic platforms.ResultsWe developed a 3-tiered grading scheme (Integrated Grades 1-3), which incorporated mitotic count and loss of chromosome 1p, 3p, 4, 6, 10, 14q, 18, 19, or CDKN2A. 32% of meningiomas reclassified to either a lower-risk or higher-risk Integrated Grade compared to their assigned WHO grade. The Integrated Grade more accurately identified meningioma patients at risk for recurrence, relative to the WHO grade, as determined by time-dependent area under the curve, average precision, and the Brier score.ConclusionWe propose a molecularly integrated grading scheme for meningiomas that significantly improves upon the current WHO grading system in prediction of progression-free survival. This framework can be broadly adopted by clinicians with relative ease using widely available genomic technologies and presents an advance in the care of meningioma patients. 相似文献
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Metabolic acidosis has seldom been reported during treatment of asthma with use of beta agonist but not with much clinical consequence. We report two cases of metabolic acidosis with hyperventilation as a direct effect of salbutamol that caused difficulty in assessment and management of their respiratory symptoms which resolved with appropriate tapering of beta agonist. 相似文献
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Role of adenosine receptors in resveratrol‐induced intraocular pressure lowering in rats with steroid‐induced ocular hypertension 下载免费PDF全文
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