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排序方式: 共有565条查询结果,搜索用时 15 毫秒
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Siegrist PT Husmann L Knabenhans M Gaemperli O Valenta I Hoefflinghaus T Scheffel H Stolzmann P Alkadhi H Kaufmann PA 《European journal of nuclear medicine and molecular imaging》2008,35(5):889-895
Purpose The purpose of the study is to determine the impact of 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI) on clinical decision making and its cost-effectiveness.
Materials and methods One hundred consecutive patients (28 women, 72 men; mean age 60.9 ± 12.0 years; range 24–85 years) underwent 13N-ammonia PET scanning (and computed tomography, used only for attenuation correction) to assess myocardial perfusion in patients
with known (n = 79) or suspected (n = 8) coronary artery disease (CAD), or for suspected small-vessel disease (SVD; n = 13). Before PET, the referring physician was asked to determine patient treatment if PET would not be available. Four weeks
later, PET patient management was reassessed for each patient individually.
Results Before PET management strategies would have been: diagnostic angiography (62 of 100 patients), diagnostic angiography and
percutaneous coronary intervention (PCI; 6 of 100), coronary artery bypass grafting (CABG; 3 of 100), transplantation (1 of
100), or conservative medical treatment (28 of 100). After PET scanning, treatment strategies were altered in 78 patients
leading to: diagnostic angiography (0 of 100), PCI (20 of 100), CABG (3 of 100), transplantation (1 of 100), or conservative
medical treatment (76 of 100). Patient management followed the recommendations of PET findings in 97% of the cases. Cost-effectiveness
analysis revealed lower costs of €206/patient as a result of PET scanning.
Conclusion In a population with a high prevalence of known CAD, PET is cost-effective and has an important impact on patient management.
P.T. Siegrist and L. Husmann contributed equally to this work. 相似文献
563.
MariaRoxana Buzan LaurianaEunice Zbîrcea Pia Gattinger Elijahu Babaev Frank Stolz Rudolf Valenta Virgil Punescu Carmen Panaitescu KuanWei Chen 《Clinical and translational allergy》2022,12(7)
BackgroundRagweed (Ambrosia artemisiifolia) is one of the most important allergen sources, worldwide, causing severe respiratory allergic reactions in late summer and fall, in sensitized patients. Amb a 1 has been considered as the most important allergen in ragweed but 12 ragweed pollen allergens are known. The aim of our study was to investigate IgE reactivity profiles of ragweed allergic patients and to associate them with clinical symptoms.MethodsIgE sensitization profiles from clinically well‐characterized ragweed allergic patients (n = 150) were analyzed using immunoblotted ragweed pollen extract. Immunoblot inhibition experiments were performed with two Amb a 1 isoforms and CCD markers and basophil activation experiments were performed with IgE serum before and after depletion of Amb a 1‐specific IgE.ResultsBy IgE‐immunoblotting 19 different IgE reactivity patterns with and without Amb a 1‐sensitization were found. The majority of patients (>95%) suffered from rhino‐conjunctivitis, around 60% reported asthma‐like symptoms and about 25% had skin reactions. Patients with complex IgE sensitization profiles tended to have more clinical symptoms. Serum with and without Amb a 1‐specific IgE induced basophil activation.ConclusionsRagweed pollen allergic patients exhibit complex IgE reactivity profiles to ragweed allergens including Amb a 1 isoforms and cross‐reactive carbohydrates indicating the importance of Amb a 1 isoforms and additional allergens for diagnosis and allergen‐specific immunotherapy of ragweed allergy. 相似文献
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