全文获取类型
收费全文 | 107776篇 |
免费 | 5705篇 |
国内免费 | 378篇 |
专业分类
耳鼻咽喉 | 2000篇 |
儿科学 | 4138篇 |
妇产科学 | 2533篇 |
基础医学 | 13498篇 |
口腔科学 | 4052篇 |
临床医学 | 8135篇 |
内科学 | 24996篇 |
皮肤病学 | 3389篇 |
神经病学 | 8538篇 |
特种医学 | 2862篇 |
外国民族医学 | 1篇 |
外科学 | 14547篇 |
综合类 | 623篇 |
一般理论 | 36篇 |
预防医学 | 9369篇 |
眼科学 | 2217篇 |
药学 | 7269篇 |
中国医学 | 605篇 |
肿瘤学 | 5051篇 |
出版年
2023年 | 826篇 |
2022年 | 1533篇 |
2021年 | 3289篇 |
2020年 | 1641篇 |
2019年 | 2958篇 |
2018年 | 3917篇 |
2017年 | 2465篇 |
2016年 | 2458篇 |
2015年 | 2568篇 |
2014年 | 3595篇 |
2013年 | 5237篇 |
2012年 | 7668篇 |
2011年 | 8510篇 |
2010年 | 4455篇 |
2009年 | 3426篇 |
2008年 | 6500篇 |
2007年 | 6873篇 |
2006年 | 6520篇 |
2005年 | 6550篇 |
2004年 | 6075篇 |
2003年 | 5617篇 |
2002年 | 5200篇 |
2001年 | 2373篇 |
2000年 | 2638篇 |
1999年 | 1958篇 |
1998年 | 771篇 |
1997年 | 668篇 |
1996年 | 560篇 |
1995年 | 476篇 |
1994年 | 427篇 |
1993年 | 322篇 |
1992年 | 621篇 |
1991年 | 510篇 |
1990年 | 493篇 |
1989年 | 396篇 |
1988年 | 394篇 |
1987年 | 346篇 |
1986年 | 313篇 |
1985年 | 290篇 |
1984年 | 200篇 |
1983年 | 190篇 |
1982年 | 180篇 |
1981年 | 175篇 |
1980年 | 146篇 |
1979年 | 172篇 |
1978年 | 135篇 |
1977年 | 94篇 |
1976年 | 95篇 |
1974年 | 115篇 |
1969年 | 95篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
53.
Preliminary data suggest that lactitol (beta-galactoside-sorbitol), a new synthetic non-absorbable disaccharide, has beneficial effects on chronic portal systemic encephalopathy. To compare the efficacy of lactitol vs. lactulose in the treatment of acute portal systemic encephalopathy (PSE), 40 cirrhotic patients with an acute episode of PSE were randomly allocated to one of two groups: group A (20 patients) received lactulose (30 ml/6 h) and group B (20 patients) lactitol (12 g/6 h). These doses were adjusted daily to obtain two bowel movements per day. The duration of treatment was 5 days. Age, sex, hepatic and renal function, precipitating factors and level of PSE measured by clinical examination, EEG and number connection test were similar in the two groups. A complete clinical resolution of PSE occurred in 11 patients in each group. In 5 patients of the lactulose group and in 6 of the lactitol group there was a moderate improvement of PSE during the study. Finally, 4 patients in the lactulose group and 3 in the lactitol group did not respond to treatment. No side effects attributable to therapy were observed in either group. These results indicate that lactitol is as effective as lactulose in the management of patients with cirrhosis and acute PSE. 相似文献
54.
55.
56.
Carmen Guillén Ponce María Pilar Garrido López María José Molina Garrido Gema Muñoz Molina Alfredo Carrato 《Clinical & translational oncology》2007,9(1):53-55
Pituitary metastases of solid tumours are infrequent, specially as a first manifestation. When they happen, they are usually
due to breast or lung cancer and are asymptomatic or produce diabetes insipidus. It is very strange that they produce hormonal
deficiency.
We present a case report of a bronchogenic adenocarcinoma in a 65-year-old man which began with panhypopituitarism, diabetes
insipidus and visual alterations. Magnetic resonance imaging revealed a large sellar mass, with clivus infiltration and invading
the right cavernous sinus. The biopsy result was adenocarcinoma metastases from lung cancer. 相似文献
57.
58.
Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals. 总被引:5,自引:0,他引:5
Anna Gumieniczek Hanna Hopka?a Jacek Roliński Agnieszka Bojarska-Junak 《Pharmacological research》2005,52(2):162-166
Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense, is considered to be an important pathogenic factor in diabetes mellitus and its complications. In diabetic state, ROS might also be implicated in promoting a state of systemic inflammation. Recently, it was demonstrated that antioxidant therapy could be used to stop the initiation and propagation of this inflammatory response. Repaglinide is a new oral antidiabetic agent with a possible antioxidant activity. Therefore, in the present study, a possible therapeutic value of repaglinide in ameliorating the oxidative and inflammatory processes was tested in diabetic animals. In the study, the levels of total antioxidant status (TAS), ascorbic acid (AA), protein carbonyl groups (PCG) and interleukin-6 (IL-6) were determined in plasma of diabetic rabbits after 4 and 8 weeks of repaglinide treatment (1mg daily). Ex vivo analysis revealed that there were significant differences in these markers between hyperglycemic and control animals (P<0.05). Some of these parameters were ameliorated by repaglinide treatment. In diabetic rabbits treated with repaglinide, protein oxidation was diminished by 17.8% after 8 weeks of experiment. The level of AA in plasma of diabetic treated animals was higher than in non-treated diabetic groups (by 9.4 and 22.6% after 4 and 8 weeks, respectively). In diabetic treated animals, the TAS level was also significantly increased (by 23.6 and 16.7%). However, in diabetic rabbits, repaglinide did not affect the concentration of IL-6. 相似文献
59.
60.
José Ignacio Bilbao Mercedes Arias Jesús María Longo Pedro Luis Alejandre María Teresa Betés Arlette María Elizalde 《Cardiovascular and interventional radiology》1997,20(2):149-153
Percutaneous embolization of large portosystemic collaterals was performed in three patients following placement of a transjugular
intrahepatic portosystemic shunt in order to improve hepatopetal portal flow. Improved hepatic portal perfusion was achieved
in these cases, thereby theoretically reducing the risk of chronic hepatic encephalopathy. 相似文献