全文获取类型
收费全文 | 6871篇 |
免费 | 484篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 168篇 |
妇产科学 | 130篇 |
基础医学 | 1211篇 |
口腔科学 | 128篇 |
临床医学 | 679篇 |
内科学 | 1445篇 |
皮肤病学 | 152篇 |
神经病学 | 653篇 |
特种医学 | 297篇 |
外国民族医学 | 17篇 |
外科学 | 693篇 |
综合类 | 34篇 |
一般理论 | 8篇 |
预防医学 | 569篇 |
眼科学 | 105篇 |
药学 | 480篇 |
中国医学 | 13篇 |
肿瘤学 | 530篇 |
出版年
2024年 | 8篇 |
2023年 | 58篇 |
2022年 | 31篇 |
2021年 | 111篇 |
2020年 | 88篇 |
2019年 | 125篇 |
2018年 | 261篇 |
2017年 | 180篇 |
2016年 | 180篇 |
2015年 | 226篇 |
2014年 | 222篇 |
2013年 | 293篇 |
2012年 | 583篇 |
2011年 | 617篇 |
2010年 | 279篇 |
2009年 | 244篇 |
2008年 | 478篇 |
2007年 | 627篇 |
2006年 | 534篇 |
2005年 | 545篇 |
2004年 | 453篇 |
2003年 | 432篇 |
2002年 | 370篇 |
2001年 | 42篇 |
2000年 | 44篇 |
1999年 | 48篇 |
1998年 | 23篇 |
1997年 | 14篇 |
1996年 | 11篇 |
1995年 | 11篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 23篇 |
1991年 | 26篇 |
1990年 | 13篇 |
1989年 | 11篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 10篇 |
1974年 | 6篇 |
1973年 | 11篇 |
1972年 | 9篇 |
1970年 | 5篇 |
1969年 | 6篇 |
1968年 | 5篇 |
1967年 | 11篇 |
1966年 | 5篇 |
排序方式: 共有7371条查询结果,搜索用时 15 毫秒
41.
42.
Lewden C Raffi F Cuzin L Cailleton V Vildé JL Chêne G Allavena C Salamon R Leport C 《The Journal of infectious diseases》2002,186(5):710-714
This study attempted to identify factors associated with mortality among human immunodeficiency virus (HIV)-infected adults starting a protease inhibitor (PI)-containing therapy. Among 1155 patients consecutively enrolled in the APROCO study between May 1997 and June 1998, clinical characteristics were as follows: median age, 36 years; median baseline CD4 cell count, 288 cells/mm(3); and median baseline plasma HIV RNA load, 4.4 log(10) copies/mL. After a median follow-up of 27 months, 48 deaths had occurred, of which 44% were related to acquired immune deficiency syndrome. The mortality rate was 2.9% at 12 months. When both data at baseline and data at 4 months after the start of PI therapy were considered, factors independently associated with mortality were (Cox model) low baseline plasma creatinine level, low school education level, low CD4 cell count at 4 months, low hemoglobin level, and elevated hepatic transaminase levels. Thus, social context plus clinical and biologic data, including the 4-month response to treatment, must be considered in treatment of HIV-infected patients. 相似文献
43.
Valim V Oliveira LM Suda AL Silva LE Faro M Neto TL Feldman D Natour J 《The Journal of rheumatology》2002,29(2):353-357
OBJECTIVE: To compare maximum oxygen uptake and anaerobic threshold in patients with fibromyalgia (FM) and healthy sedentary controls matched by sex, age, weight, and body mass index. METHODS: Fifty women with FM aged 18-60 years and 50 healthy sedentary controls were studied. All were submitted to a maximum treadmill incremental test. Expired gas, ventilatory anaerobic threshold, and maximum oxygen uptake (VO2max) were evaluated. The influence of FM on quality of life was evaluated by questionnaires: the Fibromyalgia Impact Questionnaire and the Medical Outcomes Study Short-Form (SF-36). RESULTS: In patients with FM, the anaerobic threshold and peak oxygen uptake were significantly reduced. Maximum heartbeat rate was significantly lower in FM, indicating submaximum effort. Linear regression data showed a correlation between peak VO2 and the "Role-physical" domain of the SF-36. No such correlations were noted with anaerobic threshold. CONCLUSION: These results confirm the hypothesis of lower physical fitness in patients with FM. Considering that patients with FM do not achieve a maximum effort, ventilatory anaerobic threshold should be considered as a better fitness index than VO2max. 相似文献
44.
Christina S. Lee Richard Longabaugh Janette Baird Val Streszak Ted Nirenberg Michael Mello 《Addiction Research & Theory》2015,23(5):421-428
Objective: Given the widespread potential for disseminating Motivational Interviewing (MI) through technology, the question of whether MI active ingredients are present when not delivered in person is critical to assure high treatment quality. The Participant Rating Form (PRF) was developed and used to evaluate therapist-delivered active ingredients in phone-delivered MI with hazardous drinking Emergency Department patients. Method: A factor analysis of all PRFs completed after receiving one call (n?=?256) was conducted. Multiple regression analysis was used to examine whether PRF factors predicted a measure of motivation to change – taking steps – at the second call (n?=?214). Results: The majority of participants were male (65%), with a mean age of 32 years and with an average alcohol ASSIST (Alcohol, Smoking and Substance Involvement Screening Test) score of 20.5 (SD?=?7.1). Results of the factor analysis for the PRF revealed Relational (working collaboration) and Technical (MI behaviours) factors. After controlling for demographics, alcohol severity and baseline readiness, the technical factor predicted self-report of increased taking steps towards change while the relational factor did not explain any additional variance. Conclusions: Our study adds to the growing literature investigating patient perspectives of therapist skill as a source of information to better understand MI active ingredients. The PRF is a feasible instrument for measuring the patient’s experience of phone-based MI. Results indicate that MI active ingredients of change (relational and technical components) were present in the telephone intervention as hypothesized. Clinical Trial Registration # 01326169. 相似文献
45.
46.
Valérie Biancalana Dieter Glaeser Shirley McQuaid Peter Steinbach 《European journal of human genetics : EJHG》2015,23(4):417-425
Different mutations occurring in the unstable CGG repeat in 5'' untranslated region of FMR1 gene are responsible for three fragile X-associated disorders. An expansion of over ∼200 CGG repeats when associated with abnormal methylation and inactivation of the promoter is the mutation termed ‘full mutation'' and is responsible for fragile X syndrome (FXS), a neurodevelopmental disorder described as the most common cause of inherited intellectual impairment. The term ‘abnormal methylation'' is used here to distinguish the DNA methylation induced by the expanded repeat from the ‘normal methylation'' occurring on the inactive X chromosomes in females with normal, premutation, and full mutation alleles. All male and roughly half of the female full mutation carriers have FXS. Another anomaly termed ‘premutation'' is characterized by the presence of 55 to ∼200 CGGs without abnormal methylation, and is the cause of two other diseases with incomplete penetrance. One is fragile X-associated primary ovarian insufficiency (FXPOI), which is characterized by a large spectrum of ovarian dysfunction phenotypes and possible early menopause as the end stage. The other is fragile X-associated tremor/ataxia syndrome (FXTAS), which is a late onset neurodegenerative disorder affecting males and females. Because of the particular pattern and transmission of the CGG repeat, appropriate molecular testing and reporting is very important for the optimal genetic counselling in the three fragile X-associated disorders. Here, we describe best practice guidelines for genetic analysis and reporting in FXS, FXPOI, and FXTAS, including carrier and prenatal testing. 相似文献
47.
Pers JO d'Arbonneau F Devauchelle-Pensec V Saraux A Pennec YL Youinou P 《Arthritis and rheumatism》2005,52(8):2411-2414
OBJECTIVE: To correlate the periodontal status of 15 patients with primary Sj?gren's syndrome (SS) with their salivary levels of BAFF. METHODS: The periodontal status of 15 patients who fulfilled the criteria for primary SS was compared with that of 15 controls with xerostomia who did not fulfill the criteria for primary SS but had similar symptoms of dry mouth. The level of BAFF was measured in paired samples of saliva and serum using in-house enzyme-linked immunosorbent assays. Periodontitis was assessed by the plaque index, the modified gingival index, the papillary bleeding index, and the periodontal pocket depth. RESULTS: Notwithstanding the better oral hygiene practices of the patients with primary SS compared with those of the xerostomia controls and the subsequent reduction of their plaque index scores, complications of periodontitis, such as bleeding, gingival hypertrophy, and periodontal pockets, were not improved. This failure to ameliorate the complications of periodontitis in patients with primary SS was associated with high levels of BAFF in their saliva compared with the levels in xerostomia controls (7.4 +/- 2.1 versus 1.0 +/- 0.4 ng/ml [P < 0.002]). The levels of BAFF in saliva did not correlate with the levels in sera but did correlate with the periodontal pocket depth (P < 0.002). CONCLUSION: These findings are similar to the bone resorption observed in patients with rheumatoid arthritis. They suggest that the known effect of B cells in periodontitis would be partly mediated by salivary BAFF in patients with primary SS. 相似文献
48.
Dr. Vicente Garrigues MD Julio Ponce MD Carmen Cano MD Ramón Sopena MD Melchor Hoyos MD Adolfo Del Val MD Joaquin Berenguer MD 《Digestive diseases and sciences》1992,37(1):101-104
In this study we investigated the effect of selective (M1) and non-selective (M1 and M2) pharmacologic blockade of muscarinic receptors on cholecystokinin-induced gallbladder emptying. After validating the method of study, the gallbladder function was evaluated in 15 normal volunteers by quantitative biliary scintigraphy, and the effect of intravenous atropine (0.15 mg/10 kg) and pirenzepine (10 mg) was analyzed in each subject. Atropine significantly reduced the ejection period and the ejection fraction of gallbladder evacuation. Pirenzepine reduced the ejection period, but the ejection fraction remained unchanged. We conclude that the effect of cholecystokinin on gallbladder motility is mediated through muscarinic receptors. Our results suggest that M2 receptors, but not M1 receptors, are involved in this response. 相似文献
49.
Lionel Faivre Hélène Boucher Thomas Domet André Desproges Olivier Sibony Marina Bechard Valérie Vanneaux Jérôme Larghero Audrey Cras 《Transfusion》2018,58(2):520-531
After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection. 相似文献
50.