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41.
Aghamohammadi A Montazeri A Abolhassani H Saroukhani S Pourjabbar S Tavassoli M Darabi B Imanzadeh A Parvaneh N Rezaei N 《Iranian journal of allergy, asthma, and immunology》2011,10(1):47-51
Patients with primary antibody deficiencies (PAD) are susceptible to recurrent and chronic infections and a variety of complications. This study was performed to assess quality of life (QoL) of PAD patients who were under long term treatment and regular follow-up.Thirty six adults with proved diagnosis of PAD, who had received regular intravenous immunoglobulin replacement therapy, were enrolled in this study. The QoL of selected PAD patients was measured by Medical Outcomes Study 36-item Short-Form (SF-36) Health Survey questionnaire.The patients with PAD showed significantly reduced scores in physical component in comparison with healthy age-sex matched control subjects (60.2±20.1 vs. 85.5±4.7, P<0.001). Mental component score was also significantly decreased in the patient's group (59.8±19.5 vs. 72.3±3.4, P=0.002). There was a reverse association between SF-36 scores and number of infections episodes (r=-0.73 P=0.003). The patients with long delay diagnosis showed significantly lower SF-36 scores (r=-0.62, P=0.003).The patients with PAD who were diagnosed timely and managed appropriately seem to have lower complications and better QoL. However, the patients with severe phenotypes and long delay in diagnosis showed lower QoL, even in medical management. 相似文献
42.
Montazeri G Nouri N Estakhri A Shirani S Abedian S Fazlollahi A Mikaeli J Nouraie M Malekzadeh R 《European journal of gastroenterology & hepatology》2006,18(11):1203-1208
OBJECTIVE: Subjective assessment of primary achalasia is not accurate. We aimed to study the utility of surface area of barium retention in the objective assessment of these patients. METHODS: Subjective and objective esophageal functions of 99 patients with primary achalasia were evaluated initially and 43 of them were reevaluated 1 month after balloon dilation. RESULTS: Before dilation: Ninety-nine patients were enrolled. Forty-one of them were male. The mean age was 37.5+/-15.3 years. The mean score, resting lower esophageal sphincter pressure, height, surface and volume of barium retention at 5 min were 8.03+/-3.1, 59.1+/-20 mmHg, 9.9+/-4.9 cm, and 23.6+/-13.9 cm and 53.2+/-47.7 cm, respectively. Surface area at 5 min had best correlation and predictive value for resting lower esophageal sphincter pressure. After dilation: Forty-three of 99 patients were reevaluated after balloon dilation. The mean age was 36.8+/-13.6 years. Seventeen of them were male. Mean score, resting lower esophageal sphincter pressure, height, surface area and volume of barium retention at 5 min dropped significantly after dilation. Surface area at 5 min had best correlation and predictive value for lower esophageal sphincter pressure. CONCLUSIONS: Surface area of barium retention at 5 min is an accurate objective tool to assess patients with primary achalasia. It is cheap and easy to perform; therefore, it could be used more frequently in postdilation follow-up. 相似文献
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44.
In this article, a novel technique for assessment of obstructive sleep apnea (OSA) during wakefulness is proposed; the technique
is based on tracheal breath sound analysis of normal breathing in upright sitting and supine body positions. We recorded tracheal
breath sounds of 17 non-apneic individuals and 35 people with various degrees of severity of OSA in supine and upright sitting
positions during both nose and mouth breathing at medium flow rate. We calculated the power spectrum, Kurtosis, and Katz fractal
dimensions of the recorded signals and used the one-way analysis of variance to select the features, which were statistically
significant between the groups. Then, the maximum relevancy minimum redundancy method was used to reduce the number of characteristic
features to two. Using the best two selected features, we classified the participant into severe OSA and non-OSA groups as
well as non-OSA or mild vs. moderate and severe OSA groups; the results showed more than 91 and 83% accuracy; 85 and 81% specificity;
92 and 95% sensitivity, for the two types of classification, respectively. The results are encouraging for identifying people
with OSA and also prediction of OSA severity. Once verified on a larger population, the proposed method offers a simple and
non-invasive screening tool for prediction of OSA during wakefulness. 相似文献
45.
Ali Montazeri Mariam Vahdaninia Sayed Javad Mousavi Mohsen Asadi-Lari Sepideh Omidvari Mahmoud Tavousi 《Health and quality of life outcomes》2011,9(1):12
Background
The SF-12v2 is the improved version of the SF-12v1. This study aimed to validate the SF-12v2 in Iran. 相似文献46.
47.
Zahra Taheri-Kharameh Majideh Heravi-Karimooi Nahid Rejeh Ebrahim Hajizadeh Mojtaba Vaismoradi Sherrill Snelgrove Ali Montazeri 《Health and quality of life outcomes》2017,15(1):234
Background
Angina pectoris causes substantial psychological and functional disabilities and adversely effects quality of life in patients. The aim of this study was to investigate the psychometric properties including validity and reliability of the Farsi version of the Seattle angina questionnaire.Methods
The ‘forward-backward’ procedure was applied to translate this questionnaire from English to Farsi. The translated version of the Seattle angina questionnaire was assessed in terms of validity and reliability with a convenience sample of 200 patients suffering from angina pectoris who were recruited from the inpatient ward (post CCU) and outpatient department at two teaching hospitals in an urban area of Iran. Validity was assessed using content, face and construct validity. The calculation of the Cronbach’s alpha coefficient and the test-retest method helped with the assessment of reliability of the questionnaire’s five subscales. Construct validity of the questionnaire was evaluated using exploratory factor analysis.Results
The results of exploratory factor analysis indicated a five-factor solution for the questionnaire including ‘physical limitation in middle to strenuous activities’, ‘physical limitation in slight activities’, ‘angina pattern and discomfort of treatment’, ‘treatment satisfaction’ and ‘disease perception’ that jointly accounted for 64.42% of variance observed. Convergent validity was mostly supported by the pattern of association between the Seattle angina questionnaire-Farsi version and the SF-36. Cronbach’s alpha of the subscales ranged from 0.60 to 0.86 and test-retest scores ranged from 0.79 to 0.97 indicating a good range of reliability.Conclusions
The Seattle angina questionnaire-Farsi version had acceptable psychometric properties. Therefore, it can be used to assess health-related quality of life and assess the effects of different medical and nursing interventions on patients’ quality of life.48.
Leila Abkhooie Mostafa M. Sarabi Houman Kahroba Shirin Eyvazi Soheila Montazersaheb Vahideh Tarhriz Mohammad S. Hejazi 《Current Cardiology Reviews》2021,17(4)
Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and regulate certain aspects of physiological and pathological processes in myocardiocytes, including cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders. In this review, we have summarized recent findings in the field of epigenetic modulations of myomiRs and cardiac regeneration associated with cardiac diseases. 相似文献
49.
50.
Hamdy S Haddadi A Shayeganpour A Alshamsan A Montazeri Aliabadi H Lavasanifar A 《The AAPS journal》2011,13(2):159-168
We have previously developed micelles of methoxy poly(ethylene oxide)-b-poly(ε-caprolactone) as vehicles for the solubilization and delivery of cyclosporine A (CsA). These micelles were able to reduce the renal uptake and nephrotoxicity of CsA. The purpose of the current study was to test the efficacy of polymeric micellar formulation of CsA (PM-CsA) in suppressing immune responses by either T cells or dendritic cells (DCs). The performance of PM-CsA was compared to that of the commercially available formulation of CsA (Sandimmune®). Our results demonstrate that PM-CsA could exert a potent immunosuppressive effect similar to that of Sandimmune® both in vitro and in vivo. Both formulations inhibited phenotypic maturation of DCs and impaired their allostimulatory capacity. Furthermore, both PM-CsA and Sandimmune® have shown similar dose-dependent inhibition of in vitro T cell proliferative responses. A similar pattern was observed in the in vivo study, where T cells isolated from both PM-CsA-treated and Sandimmune®-treated mice have shown impairment in their proliferative response and IFN-γ production at similar levels. These results highlight the potential of polymeric micelles to serve as efficient vehicles for the delivery of CsA. 相似文献