全文获取类型
收费全文 | 2188篇 |
免费 | 123篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 40篇 |
妇产科学 | 41篇 |
基础医学 | 178篇 |
口腔科学 | 91篇 |
临床医学 | 159篇 |
内科学 | 420篇 |
皮肤病学 | 71篇 |
神经病学 | 104篇 |
特种医学 | 110篇 |
外科学 | 464篇 |
综合类 | 35篇 |
一般理论 | 5篇 |
预防医学 | 257篇 |
眼科学 | 51篇 |
药学 | 151篇 |
中国医学 | 8篇 |
肿瘤学 | 125篇 |
出版年
2024年 | 4篇 |
2023年 | 30篇 |
2022年 | 65篇 |
2021年 | 111篇 |
2020年 | 78篇 |
2019年 | 86篇 |
2018年 | 116篇 |
2017年 | 64篇 |
2016年 | 73篇 |
2015年 | 85篇 |
2014年 | 97篇 |
2013年 | 134篇 |
2012年 | 172篇 |
2011年 | 182篇 |
2010年 | 118篇 |
2009年 | 71篇 |
2008年 | 139篇 |
2007年 | 126篇 |
2006年 | 135篇 |
2005年 | 113篇 |
2004年 | 99篇 |
2003年 | 69篇 |
2002年 | 56篇 |
2001年 | 14篇 |
2000年 | 12篇 |
1999年 | 19篇 |
1998年 | 21篇 |
1997年 | 7篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有2332条查询结果,搜索用时 0 毫秒
91.
92.
93.
94.
BackgroundEndometriosis can lead to infertility. Since there is no definitive treatment for endometriosis, animal modelling seems necessary to examine the possible treatments. Mouse endometrium cannot be separated for endometriosis induction. In addition, transplantation of uterus into the abdominal viscera to induce endometriosis causes organ damage. In this study, we defined a new model of endometriosis leading to separability of endometrium and a safe anatomical region for transplantation.MethodsForty female mice were allocated to 5 groups: 1, sham; 2, allograft uterus transplantation of mice to anterior abdominal wall of mice; 3, allograft uterus transplantation of mice to mesentery of mice; 4, xenograft endometrial transplantation of rat to anterior abdominal wall of mice; 5, xenograft endometrial transplantation of rat to mesentery of mice. Adult female rats with a previous pregnancy experience were selected and placed in the vicinity of male rats for 2 weeks to induce estrogen secretion and increase endometrial thickness.ResultsIn the 4th group of animals, compared to sham, the peritoneal concentrations of VEGF‐A, TNF‐α, NO, MDA, and serum levels of CA‐125 and IL‐37 were increased and total body weight was decreased, while weight and size of endometrial lesions were increased significantly (P < .05). Genes expression of HOXA10 and HOXA11 were decreased significantly (P < .05) in groups 2 and 4 compared to sham.ConclusionsXenograft transplantation of endometrium from rat to anterior abdominal wall of mice can potentially mimic human endometriosis morphologically, histologically, and genetically. 相似文献
95.
Shih-Chia Tso Xiangbing Qi Wen-Jun Gui Jacinta L. Chuang Lorraine K. Morlock Amy L. Wallace Kamran Ahmed Sunil Laxman Philippe M. Campeau Brendan H. Lee Susan M. Hutson Benjamin P. Tu Noelle S. Williams Uttam K. Tambar R. Max Wynn David T. Chuang 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(24):9728-9733
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes. BCAA homeostasis is controlled by the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC), which is negatively regulated by the specific BCKD kinase (BDK). Here, we used structure-based design to develop a BDK inhibitor, (S)-α-chloro-phenylpropionic acid [(S)-CPP]. Crystal structures of the BDK-(S)-CPP complex show that (S)-CPP binds to a unique allosteric site in the N-terminal domain, triggering helix movements in BDK. These conformational changes are communicated to the lipoyl-binding pocket, which nullifies BDK activity by blocking its binding to the BCKDC core. Administration of (S)-CPP to mice leads to the full activation and dephosphorylation of BCKDC with significant reduction in plasma BCAA concentrations. The results buttress the concept of targeting mitochondrial BDK as a pharmacological approach to mitigate BCAA accumulation in metabolic diseases and heart failure. 相似文献
96.
97.
98.
99.
Kamran Ahmed Simon Rowland Vanash Patel Reenam S. Khan Hutan Ashrafian David Ceri Davies Ara Darzi Thanos Athanasiou Paraskevas A. Paraskeva 《The surgeon》2010,8(6):318-324
IntroductionAnatomy has been considered a core subject within the medical education curriculum. In the current setting of ever-changing diagnostic and treatment modalities, the opinion of both students and trainers is crucial for the design of an anatomy curriculum which fulfils the criteria required for safe medical practice.MethodsMedical students, trainees and specialist trainee doctors and specialists from the London (England) area were surveyed to investigate the how curriculum changes have affected the relevance of anatomical knowledge to clinical practice and to identify recommendations for optimum teaching methods. The survey employed 5-point Likert scales and multiple-choice questions. Where the effect of training level was statistically significant (p < 0.05), post-hoc analysis was carried out using Mann–Whitney U tests. Significance levels were modified according to the Bonferroni method.ResultsTwo hundred and twenty-eight individuals completed the survey giving a response rate of 53%. Medical students, trainees and specialists all agreed (mean Likert score 4.51, 4.79, 4.69 respectively) that knowledge of anatomy is important for medical practice. Most of the trainees (88.4%) and specialists (81.3%) used dissection to learn anatomy, but only 61.4% of medical students used this approach. Dissection was the most commonly recommended approach for learning anatomy across all the groups (41.7%–69.3%).ConclusionsKnowledge of anatomy is perceived to be important for safe clinical practice. Anatomy should be taught with other relevant system or clinical modules. Newer tools for anatomy teaching need further validation before incorporation into the curriculum. 相似文献
100.
Tim T. Wang Kamran Ahmed Vanash M. Patel Leanne Harling Muhammed Jawad Ara Darzi Ludwig Karl von Segesser Thanos Athanasiou 《European journal of cardio-thoracic surgery》2011,40(4):816-825
The conventional methods of education, certification and recertification in cardiothoracic surgery face a paradigm shift in line with recent innovations in diagnostics and therapeutics. The attributes of a competent clinician entail proficiency in knowledge, communication, teamwork, management, health advocacy, professionalism and technical skills. This article investigates the skills required for a cardiothoracic surgeon to be competent. The relevant practice of certification and recertification across various regions has also been explored. Validated and competency-based curricula should be designed to develop core competencies to successfully integrate them into practice. Challenges to the implementation of such curricula and potential solutions are explored. Patient safety remains the ultimate aim to ensure excellence of both competency and performance. 相似文献