Lymphorhoea--complication after lymph node dissection in cervical cancer

The lymphorrhea is a problem that we fase in the early postoperative period in patients undergoino lymph node dissection (LND) for treatment of cervical cancer (CC). MATERIAL AND METHOD: In a retrospective study of 2-year period (January 2001-December 2003). We covered totaly 129 cases with invasive CC. All patients in the study have undergone surgical remove of the uterus and adnexes but in a different volume, an extended hysterectomy was performed in 125 women, in 3 patients was carried out only supravaginal hysterectomy due to failure to remove the cervix, without direct life-threatening intraoperative complications, only in one case was performet LHT with adnexes because of severe co-morbidities of patients. We don't have cases in which LND was carried out in whatever type it is--a diagnostic or therapeutic. All women undergone LND in a different volume 123 cases pelvic LND/PLND/ and/or paraaortic LND/PALND/, selective LND in 3 patients, only PAND in 2 cases and biopsy of pelvic lymph node--only one case. AIM AND GOALS: Our aim is to present the role of lymphorrhea in the observed cases according the type of LND applied to treat invesiv CC. We set the following goals--To present the frequency of lymphorrhea in the early postoperative period in our patients treated for invasive CC, and the presence or absence of a link between the level of LND and the observed lymphorrhea. RESULTS: On the basis of the above data we can make the following conclusions: Lymphorrhea was recorded in 24 or 18.60% of the cases of our study. It is a complication that directly depends on the type of the performed LND. It is the second most common complication--24 women the undercoing PLND--11 (45.8%) and PLND+PALND--13 (54.2%).     

Facilitated Synthesis of Mg2Ni Based Composites with Attractive Hydrogen Sorption Properties

Composites based on Mg₂Ni with 5% activated carbon from apricot stones (ACAP) have been prepared by ball milling and subsequent annealing in hydrogen atmosphere. The purpose of the primary metal (Mg, Ni, and V) milling was to reduce the particle size and achieve a good contact between them, without forming intermetallic compounds. During hydriding/dehydriding at 300 °C the amount of the Mg₂Ni phase progressively increased, and after 10 cycles about 50% Mg₂(Ni,V) was achieved. The hydrogenation produced mainly Mg₂NiH₄, but small amounts of MgH₂ and VH_x were also detected in the powder mixture. Relatively high hydrogen storage capacity and fast hydriding/dehydriding kinetics of the Mg_2.1Ni_0.7V_0.3—5 wt.% ACAP composite were determined both from hydrogen gas phase and electrochemically.     

Electron microscopic and enzyme investigations of the testicular tissue in infertile males

The ultrastructural characteristics of the testicular tissue in male infertility and the isoenzyme spectrum of some enzymes in sperm cells have been studied. The testicular material was taken by Vilar's method from three healthy males with normospermia and eleven males with hypogonadism, azoospermia and infertility.The material was treated by the routine methods for electron investigation and the observations were done with an electron microscope Opton EM 109. Horizonatal electrophoresis of the testicular homogenate was done according to Nance. Malate dehydrogenetic activity (MDX) was rendered according to the method of Shaw and Prasad, and diaphoresis (DP) was carried out according to Brewer.It was found that spermatogenesis was interrupted at the pachytene stage at an ultrastructural level. Biochemical investigations showed that in the infertile testis two other atypical fractions appeared on diaphoresis, while at the malate dehydrogenase, a second fraction had considerably lower intensity as compared to the controls.It is pointed out that some profound disorders developing in the infertile testis affect mainly the germinal cells, which was proved at the ultrastructural level and also by the analysis of the isoenzymes MDH and DF key enzymes of carbohydrate metabolism.     

Surgical management of extensive gnathophyma

Rhinophyma is an uncommon disease of the nose characterized by irregular skin thickening and nodular deformation. The extensive growth causing 'whisky nose' is due to hyperplasia of the sebaceous glands and the surrounding connective tissue. Other facial regions may concomitantly be affected. We present a case of extensive gnathophyma accompanying minor lesions of the nose. Surgical treatment led to an excellent cosmetic result.     

Is growth hormone a radioprotective agent?

There is currently substantial clinical interest in growth hormone (GH) as a protective agent against radiation-related normal tissue injury. To further assess the potential radiation injury-preventive effects of GH, these effects were studied in rats by using a radiation-induced skin injury model. Group 1 received neither GH nor irradiation (control group). Group 2 received 30 Gy of gamma irradiation as a single dose to the right hind legs of the rats (radiation group). Group 3 and 4 received the same irradiation plus either 0.01 U/kg/day GH (RT + 0.01 GH group) or 0.02 U/kg/day GH (RT + 0.02 GH group) subcutaneously. Clinically and histopathologically, acute skin reactions were assessed by two independent experts in radiation oncology and pathology, respectively. Irradiation increased dermatitis in rats when compared with the control group. The severity of radiodermatitis in the rats in the RT + 0.01 GH and RT + 0.02 GH groups was significantly lower than that in the RT group; radiodermatitis developed earlier in the RT group than in the other groups. GH was efficacious in preventing epidermal atrophy, dermal degeneration such as oedema and collagen fibre loss, and hair follicle atrophy, but not better than in the control group. These results are preliminary to studies that will be performed with higher doses of GH in radiation-treated cancer patients, with the aim of reducing radiation-induced toxicity.     

附睾降解性不活动精子症的研究

目的 :探讨精子不活动是否由附睾降解引起。方法 :本文选择 5例精液中无活动精子的不育患者 ,应用睾丸精子活力检测、精子头 -尾膜完整性结合试验和透射电镜观察 ,探讨其精子不活动的原因。结果 :5例患者睾丸活检组织所分离的睾丸精子 ,经孵育后的活动率为 2 %～ 1 1 %。睾丸精子组中头膜 -尾膜均完整的精子率显著高于射出精子组 ( P<0 .0 1 )。睾丸精子未见明显的降解 ,但透射电镜显示射出精子的浆膜、核等结构表现显著的降解变化。结论 :本组患者的精子可能经历了病理性附睾降解 ,引致精子丧失活动性 ,对这类患者采用活动的睾丸精子作辅助生育治疗有可能改善成功率。