全文获取类型
收费全文 | 949篇 |
免费 | 59篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 28篇 |
妇产科学 | 24篇 |
基础医学 | 95篇 |
口腔科学 | 22篇 |
临床医学 | 69篇 |
内科学 | 249篇 |
皮肤病学 | 49篇 |
神经病学 | 65篇 |
特种医学 | 27篇 |
外科学 | 80篇 |
综合类 | 2篇 |
预防医学 | 90篇 |
眼科学 | 18篇 |
药学 | 98篇 |
肿瘤学 | 97篇 |
出版年
2023年 | 5篇 |
2022年 | 22篇 |
2021年 | 40篇 |
2020年 | 29篇 |
2019年 | 28篇 |
2018年 | 34篇 |
2017年 | 27篇 |
2016年 | 30篇 |
2015年 | 30篇 |
2014年 | 46篇 |
2013年 | 55篇 |
2012年 | 66篇 |
2011年 | 73篇 |
2010年 | 39篇 |
2009年 | 29篇 |
2008年 | 62篇 |
2007年 | 54篇 |
2006年 | 46篇 |
2005年 | 51篇 |
2004年 | 46篇 |
2003年 | 52篇 |
2002年 | 41篇 |
2001年 | 8篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 7篇 |
1993年 | 7篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1969年 | 2篇 |
1928年 | 1篇 |
1927年 | 3篇 |
1920年 | 1篇 |
排序方式: 共有1015条查询结果,搜索用时 15 毫秒
131.
Anastasia Therianou Magdalini Vasiadi Danae A. Delivanis Theodora Petrakopoulou Alexandra Katsarou‐Katsari Christina Antoniou Alexandros Stratigos Irene Tsilioni Andreas Katsambas Dimitris Rigopoulos Theoharis C. Theoharides 《Experimental dermatology》2019,28(1):72-75
Psoriasis is characterized by keratinocyte proliferation and chronic inflammation, but the pathogenesis is still unclear. Dysregulated mitochondria (mt) could lead to reduced apoptosis and extracellular secretion of mtDNA, acting as “innate pathogen” triggering inflammation. Serum was obtained from healthy volunteers and psoriatic patients. Mitochondrial DNA was extracted from the serum and amplified with quantitative PCR (qPCR). Punch biopsies were obtained from lesional and non‐lesional psoriatic skin (10 cm apart) and from healthy volunteers, were placed in RNA later and were stored at ?80°C until RNA was extracted and cDNA was synthesized; gene expression of uncoupling protein 2 (UCP2), Dynamin‐related protein 1 (Drp1) and calcineurin, involved in the regulation of mitochondria function, was detected with qPCR. Mitochondrial DNA was significantly increased (7s, P = 0.0496 and Cytochrome B, CytB, P = 0.0403) in the serum of psoriatic patients (n = 63) as compared to controls (n = 27). Gene expression was significantly reduced for UCP2 (P = 0.0218), Drp1 (P = 0.0001) and calcineurin (P = 0.0001) in lesional psoriatic skin, as compared to non‐lesional or control skin. Increased serum extracellular mtDNA in psoriatic patients and decreased expression of mitochondrial regulatory proteins in psoriatic skin suggest increased inflammation and reduced keratinocyte apoptosis, respectively. Inhibitors of mtDNA secretion and/or UCP2 stimulants may be potential treatment options. 相似文献
132.
ADF Winter School—An exciting concept of the Arbeitsgemeinschaft Dermatologische Forschung to connect young scientists and clinician scientists in Dermatology at the top of Germany 下载免费PDF全文
Amir S. Yazdi Meltem Barlin Katharina Böhm Fabian Gendrisch Saeedeh Ghorbanalipoor Stefanie Häberle Annamarie Hamel Svea Hüning Clemens Hüttner Irina Iwanova Theodora Kanaki Susanne Kimeswenger Nadine Lohmann Saira Munir Sukalp Muzumdar Manuel Pedro Pereira Patricia Peking Kristin Plesser Adriana Rendon Maximilian Rentschler Carolin Schlumprecht Anna Smorodchenko Martin Stock Jessica Tillmanns Ugur Uslu Kamran Ghoreschi Martin Glatz Stephan Grabbe Manfred Kunz Ralf Ludwig Karin Scharffetter‐Kochanek Karin Loser 《Experimental dermatology》2017,26(3):292-294
133.
134.
Theodora G. Stroubouki 《Nurse education in practice》2012,12(4):e32
135.
136.
Kenia Pedrosa Nunes Amanda Almeida de Oliveira Theodora Szasz Vinicia Campana Biancardi R. Clinton Webb 《The journal of sexual medicine》2018,15(9):1235-1245
Introduction
While increased toll-like receptor (TLR)4 activity may contribute to the pathophysiology of vascular diseases, the molecular mechanisms disrupted by this receptor in the vasculature are still poorly understood. Additionally, it is unknown if TLR4 mediates erectile dysfunction (ED) during diabetes.Aim
To investigate whether pharmacological blockade of TLR4 affects erectile function in a murine model of diabetes.Methods
Sprague Dawley rats (Charles River Laboratory, Wilmington, MA, USA) received a single streptozotocin injection (65 mg/kg, 28 days) and were treated with an anti-TLR4 antibody (1 μg/d, intraperitoneally) for the last 14 days of the treatment. Additionally, cavernosal strips were acutely incubated for 30 minutes with CLI-095 (10?5 mol/L), a TLR4 inhibitor. Functional studies, Western blotting, erectile function, immunohistochemistry, and biochemical analyses were performed.Main Outcome Measures
Oxidative stress, cyclic guanosine monophosphate (cGMP) levels, and functional studies were evaluated in treated and nontreated cavernosal strips from control and diabetic animals. Additionally, in vivo erectile function was assessed.Results
Enhanced TLR4 expression was observed in corpus cavernosum from diabetic rats compared with control animals. Long-term blockade of TLR4 slightly improved diabetes–induced ED in rats due to attenuation of oxidative stress and increased cGMP levels in penile tissue, which ameliorated cavernosal relaxation. Functional experiments revealed that acute or chronic inhibition of TLR4 decreased hypercontractility in response to phenylephrine and improved nitrergic relaxation in corpus cavernosum from diabetic rats.Clinical Implications
TLR4 blockade may be a novel therapeutic strategy to assist in ED management.Strengths & Limitations
The strength of this article stems from the fact that we showed that TLR4 blockade partly improves erectile function in vivo in diabetic rats. Its limitations mainly include that messenger RNA analysis for the nitric oxide/cGMP pathway were not performed.Conclusion
In summary, TLR4 participates in the mechanisms of diabetes-associated ED and blockade of this receptor positively affects penile vascular function.Nunes KP, de Oliveira AA, Szasz T, et al. Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats. J Sex Med 2018;15:1235–1245. 相似文献137.
Rebecca Georgakopoulou Angeliki Andrikopoulou Theodoros N. Sergentanis Oraianthi Fiste Flora Zagouri Maria Gavriatopoulou Theodora Psaltopoulou Efstathios Kastritis Evangelos Terpos Meletios-Athanasios Dimopoulos 《Clinical Lymphoma, Myeloma & Leukemia》2021,21(6):361-367
BackgroundObesity and high body mass index (BMI) are associated with increased incidence of multiple myeloma (MM). MM usually evolves from a precursor asymptomatic disease, namely monoclonal gammopathy of undetermined significance (MGUS). MGUS progresses to MM at a 1% annual rate; however, risk factors predisposing to MGUS are not completely understood. We conducted a systematic review to assess the relationship between obesity and high BMI with MGUS prevalence and progression to MM. To our knowledge, this is the first systematic review evaluating the role of obesity in MGUS.Patients and MethodsWe searched the Medline database and ClinicalTrials.gov for studies investigating BMI and obesity association with MGUS incidence and progression. The algorithm consisted of a predefined combination of the words “obesity,” “obese,” “body mass index,” “overweight,” “diet,” “nutrition,” “food,” “dietary,” “adiponectin,” “monoclonal gammopathy,” and “MGUS”.ResultsOverall, 12 articles were retrieved, including 11 eligible articles and 1 clinical trial. More than 57,068 patients were evaluated in this systematic review. Discrepancies between the identified studies were noted. Multiple studies support the notion that obesity or high BMI are positively linked to MGUS prevalence and transition to MM. In contrast, other studies revealed no such association. Visceral adipose tissue metabolic activity and decreased adiponectin concentrations were identified as biomarkers of MGUS progression to MM.ConclusionObesity and increased BMI seem to be implicated both in MGUS development and progression to MM. Further studies should be designed to confirm this hypothesis. 相似文献
138.
Theodora Bareka Heidrun Panhofer Sarah Rodriguez Cigaran 《Body, Movement and Dance in Psychotherapy: An International Journal for Theory, Research and Practice》2019,14(2):80-94
This article looks at the link between social exclusion and migration, in particular for children. It highlights the impact that being a refugee may have on one’s sense of self. Beyond the concept of acartesian self, our working model suggests a dialogical and multi-voiced self: a self that is not isolated from other aspects of the person but involves social, political and embodied dimensions. The term embodied political self is proposed, referring to the self as an active agent, with a sense of physical cohesion and a sense of belonging to the wider social and political environment. We discuss how experiencing social exclusion impacts refugees, in particular children, and their embodied political self. Finally, a two-step dance movement therapy (DMT) intervention that seeks the reconstruction of the embodied political self is proposed. 相似文献
139.
140.
Concomitant alterations of metabolic parameters,cardiovascular risk factors and altered cortisol secretion in patients with adrenal incidentalomas during prolonged follow‐up 下载免费PDF全文