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A lipoprotein lipase activator,NO-1886 prevents impaired endothelium-dependent relaxation of aorta caused by exercise in aged rats 总被引:2,自引:0,他引:2
Kusunoki M Tsutsumi K Hara T Ogawa H Nakamura T Miyata T Sakakibara F Fukuzawa Y Suga T Kakumu S Nakaya Y 《Experimental gerontology》2002,37(7):891-896
Exercise decreases plasma total cholesterol and triglycerides, and simultaneously, increases high density lipoprotein (HDL) cholesterol. As a result, exercise is believed to aid in preventing atherosclerosis. However, we do not know whether exercise protects against the development of atherosclerosis in the elderly. The aim of this study was to ascertain whether the lipoprotein lipase activator NO-1886 had an effect on the prevention of atherosclerosis in aged rats which undergo exercise. Exercise for 3 months did not affect plasma lipids but decreased the accumulation of visceral fat in 2-year-old rats (aged rat). Exercise also resulted in an elevation of plasma lipid peroxide (LPO) levels and impaired the endothelium-dependent relaxation of the thoracic aorta caused by acetylcholine in aged rats. On the other hand, NO-1886 decreased plasma triglycerides and increased HDL cholesterol and suppressed the elevation of plasma LPO levels caused by exercise. Furthermore, NO-1886 prevented impaired endothelium-dependent relaxation caused by exercise. In summary, the results of our study indicate that exercise may cause impaired endothelium-dependent relaxation by elevation of LPO in aged rats, and that NO-1886 prevents this impaired endothelium-dependent relaxation of aorta by reducing plasma triglycerides, elevating HDL cholesterol, and suppressing the elevation of plasma LPO caused by exercise. 相似文献
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Tsutsumi YM Horikawa YT Jennings MM Kidd MW Niesman IR Yokoyama U Head BP Hagiwara Y Ishikawa Y Miyanohara A Patel PM Insel PA Patel HH Roth DM 《Circulation》2008,118(19):1979-1988
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The leucine twenty homeobox (LEUTX) gene,which lacks a histone acetyltransferase domain,is fused to KAT6A in therapy‐related acute myeloid leukemia with t(8;19)(p11;q13) 下载免费PDF全文
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Keiko Fujisawa Tetsuyuki Yasuda Hideaki Kaneto Naoto Katakami Mayumi Tsuji Fumiyo Kubo Shugo Sasaki Kazuyuki Miyashita Toyoko Naka Ryuuichi Kasami Akio Kuroda Munehide Matsuhisa Iichiro Shimomura 《Journal of diabetes investigation.》2014,5(5):548-553
Aims/Introduction
The aim of the present study was to examine the short‐ and long‐term effect of sitagliptin on glucose tolerance after near normalization of glycemic control with insulin in poorly controlled type 2 diabetic patients.Materials and Methods
We consecutively enrolled a total of 30 type 2 diabetic patients whose glycated hemoglobin levels (National Glycohemoglobin Standardization Program) were ≥7.4%, stopped all oral antidiabetic drugs and started insulin therapy. When fasting plasma glucose levels became <140 mg/dL, we carried out the first oral glucose tolerance test (OGTT). After 1‐week sitagliptin treatment (50 mg/day), the second OGTT was carried out. Furthermore, we evaluated the long‐term efficacy of sitagliptin on glucose tolerance after near normalization of glycemic control with insulin.Results
After 1‐week sitagliptin treatment, the area under the curve of insulin was markedly increased, and the area under the curve of glucagon and glucose was markedly decreased. Duration of diabetes and insulin secretory capacity were correlated with the effect of sitagliptin. Furthermore, interestingly, near normalization of glycemic control with insulin therapy for 1–2 weeks brought out the long‐term effectiveness of sitagliptin on glucose tolerance for 24 weeks, which was not observed with other antidiabetic drugs.Conclusions
These findings suggest that near normalization of glycemic control with insulin improves the clinical response to sitagliptin in poorly controlled type 2 diabetic patients. 相似文献108.
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