全文获取类型
收费全文 | 1715篇 |
免费 | 101篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 63篇 |
妇产科学 | 35篇 |
基础医学 | 245篇 |
口腔科学 | 9篇 |
临床医学 | 218篇 |
内科学 | 272篇 |
皮肤病学 | 28篇 |
神经病学 | 270篇 |
特种医学 | 54篇 |
外科学 | 146篇 |
综合类 | 8篇 |
一般理论 | 4篇 |
预防医学 | 182篇 |
眼科学 | 22篇 |
药学 | 147篇 |
中国医学 | 3篇 |
肿瘤学 | 82篇 |
出版年
2024年 | 3篇 |
2023年 | 22篇 |
2022年 | 44篇 |
2021年 | 84篇 |
2020年 | 62篇 |
2019年 | 65篇 |
2018年 | 72篇 |
2017年 | 47篇 |
2016年 | 46篇 |
2015年 | 68篇 |
2014年 | 80篇 |
2013年 | 105篇 |
2012年 | 167篇 |
2011年 | 144篇 |
2010年 | 68篇 |
2009年 | 72篇 |
2008年 | 90篇 |
2007年 | 103篇 |
2006年 | 88篇 |
2005年 | 70篇 |
2004年 | 55篇 |
2003年 | 52篇 |
2002年 | 53篇 |
2001年 | 25篇 |
2000年 | 25篇 |
1999年 | 18篇 |
1998年 | 17篇 |
1997年 | 7篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 8篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1984年 | 1篇 |
1982年 | 3篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1964年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有1821条查询结果,搜索用时 19 毫秒
151.
Tessa Garside Fiona M. Wood Ann-Maree Vallence 《Burns : journal of the International Society for Burn Injuries》2018,44(5):1195-1202
Objective
The study aimed to investigate intracortical inhibition following a burn injury, and to establish transcranial magnetic stimulation (TMS) as a useful and sensitive tool to investigate the cortical response to a burn injury.Methods
Thirteen burn injured patients and 12 uninjured subjects underwent TMS to measure the cortical silent period (cSP), a marker of intracortical inhibition.Results
In burn injury patients, cSP was similar in the burn-injured and less-injured arm (133 and 132 ms respectively; p = 0.96). cSP was numerically shorter in burns patients than control subjects, however, these differences were not statistically significant (133 vs 148 ms, p = 0.24). Subgroup analysis revealed cSP was shorter in the burn arm of patients compared to the uninjured control subjects in patients with upper-limb burn (cSP 120 ms vs 148 ms, p = 0.03), those with <10% TBSA (cSP 120 ms vs 148 ms, p = 0.01), those <2 years’ post-burn (cSP 110 ms vs 148 ms, p = 0.01), and patients with partial thickness burns (cSP 120 ms vs 148 ms, p = 0.02).Conclusions
These results demonstrate significantly shorter cSP in the burned arm in patients with upper limb burn sustained <2 years ago, those with partial thickness burns, those with upper limb burns only, and those with burns of less than 10% TBSA. The results are consistent with the existing literature, which demonstrates a reduction in cSP duration in patients with a range of peripheral nerve injuries. There is a strong suggestion that cortical inhibition is altered following burn injury, and that TMS is a useful and sensitive method for investigating changes in cortical inhibition in burn patients. 相似文献152.
ADC mapping of neurodegeneration in the brainstem and cerebellum of patients with progressive ataxias 总被引:1,自引:0,他引:1
Della Nave R Foresti S Tessa C Moretti M Ginestroni A Gavazzi C Guerrini L Salvi F Piacentini S Mascalchi M 《NeuroImage》2004,22(2):698-705
Analysis of the apparent diffusion coefficient (ADC) maps derived from diffusion-weighted MR imaging is emerging as a reproducible, sensitive, and quantitative tool to evaluate brain damage in diseases of the white and gray matter. To explore the potentials of ADC maps analysis in degenerative ataxias, we examined 28 patients and 26 age-matched controls with T1, T2, and diffusion (b values 0-1000 along the three main body axes)-weighted MR images. Twenty-four patients had inherited genetically proven diseases including spinocerebellar ataxia type 1 (SCA1) (n = 9), spinocerebellar ataxia type 2 (SCA2) (n = 8), and Friedreich's ataxia (FA) (n = 7), whereas four patients had sporadic adult onset pure cerebellar ataxia (three idiopathic, one gluten intolerance). Area and linear measurements of the CNS structures contained in the posterior cranial fossa (PCF) preliminary enabled classification of the patients in the three morphological categories reflecting the gross pathology findings, namely olivopontocerebellar atrophy (OPCA) (n = 10: six SCA2 and four SCA1), spinal atrophy (SA) (n = 7: all FA), and cortical cerebellar atrophy (CCA) (n = 4: three idiopathic and one gluten intolerance). Seven patients with SCA1 (n = 5) or SCA2 (n = 2) had morphologic changes reminiscent of OPCA, but their values were still in the lower normal range and were classified as undefined. Mean diffusivity (D) maps of the entire brain were generated and D was measured with regions of interest (ROI) in the medulla, pons, middle cerebellar peduncles, and the peridentate white matter. Moreover, after exclusion of the skull with manual segmentation and of the CSF with application of a threshold value, histograms were obtained for D of the brainstem and cerebellum and for D of the cerebral hemispheres. As compared to controls, a (P < 0.001) increase of D was observed in the medulla, middle cerebellar peduncles, and peridentate white matter in OPCA and undefined patients groups who had also significantly increased values of the 25th and 50th percentiles in the brainstem and cerebellum D histogram. In CCA (P = 0.01), an increase of the 25th and 50th percentile of the D value was observed in the brainstem and cerebellum histograms. The SA group showed (P < 0.001) an increased D in the medulla only. A correlation between clinical severity as assessed with the Inherited Ataxias Clinical Rating Scale (IACRS) and the 50th percentile of the D value in the brainstem and cerebellum histogram (r = 0.69) was observed in patients with SCA1 or SCA2. Diffusion MR imaging reveals variable patterns of increase of D in the brainstem, cerebellum, and cerebral hemispheres in degenerative ataxias that match the known distribution of the neuropathological changes. 相似文献
153.
Non-consultant career grade (NCCG) doctors in genitourinary medicine (GUM) perform a large proportion of the clinical work. To ensure quality of service delivery to patients, it is essential that these doctors keep up to date. Seven hundred questionnaires were sent to NCCGs in the UK to evaluate their knowledge of national guidelines and access to information technology. A summary of the 224 replies (31% response) is presented. Knowledge of guidelines (76%-86%) and access to the Internet at work (39%-44%) varied according to the number of sessions worked in GUM per week and by grade of doctor. Knowledge of relevant websites was poor, ranging from 40%-54% for the Medical Society for the Study of Venereal Diseases (MSSVD) website and 21%-39% for the Association of Genitourinary Medicine (AGUM) website. This survey highlights areas for concern, especially with regard to NCCGs who work three or less GUM sessions per week. 相似文献
154.
155.
Alison M. Kozlowski Tessa Taylor Denise Pichardo Peter A. Girolami 《Journal of developmental and physical disabilities》2016,28(3):443-460
Treatment of liquid refusal in pediatric feeding disorders is essential for decreasing tube dependence, alleviating some medical conditions (e.g., constipation), and increasing caloric and nutritional intake (e.g., formulas). Although investigators have conducted edible preference assessments for solids, there are no studies to our knowledge in which investigators have evaluated liquid preference prior to and during treatment of liquid refusal. In the current study, we evaluated liquid preferences repeatedly over time during behavioral treatment for liquid refusal. Although none of the children demonstrated a preference for liquids during a paired-choice preference assessment, 2 of the 3 children showed a preference when we implemented an avoidance component. However, for all 3 children, latency to acceptance and inappropriate mealtime behavior decreased for liquids during behavioral treatment with undifferentiated responding between liquid types. Future research may evaluate the utility and correlation of liquid preference assessments preceding treatment for liquid refusal. 相似文献
156.
Tessa Hart John Whyte Monica Vaccaro Amanda R. Rabinowitz 《Archives of physical medicine and rehabilitation》2019,100(5):987-989
Objective
Determine agreement between self-reported dose and dose reflected in administrative records of outpatient physical, occupational, and speech therapies at 6 and 12 months after severe traumatic brain injury (TBI), for the purpose of examining accuracy and predictors of accuracy of self-reported health care utilization in this population.Design
Secondary analysis of survey used in a larger study; participants were queried about therapy doses using a structured interview, either alone or assisted by relatives if they so chose, with responses compared to administrative records.Setting
Rehabilitation center providing outpatient TBI therapies.Participants
Sixty-five people with severe TBI living in the community provided 6-month data (N=65); 54 provided 12-month data.Interventions
Not applicable.Main Outcome Measures
Degree of agreement with administrative records of scheduled and billed therapy appointments, measured using intraclass correlation coefficients (ICCs), with linear regression used to predict accuracy from demographic variables and cognitive status.Results
ICCs were in the moderate range at 6 months, but were more variable, with some in the poor range, at 12 months. Agreement was higher for scheduled than for billed (attended) appointments. Assisted and unassisted patients provided comparable agreement with records. No demographic factors were associated with accuracy, but lower cognitive FIM scores, as hypothesized, tended to predict lower agreement at 6 months.Conclusions
People with severe TBI can provide reasonable estimates of commonly prescribed outpatient therapy doses at 6 months postinjury. Accuracy may be improved by inviting patients to request assistance from relatives and by asking them to consider attended (vs scheduled) sessions. 相似文献157.
The absorption, tissue distribution, elimination, and metabolism of [1-14C]-PFHx in rats and mice dosed orally at 2 or 100 mg/kg was evaluated following a single dose or after 14 consecutive doses. Absorption was rapid in rats as evidenced by a short time to maximum concentration (Cmax) of 30 min in male rats and 15 min in female rats at both the 2 and 100 mg/kg dose level. The plasma elimination half-life was somewhat longer in males (1.5-1.7 h) than in females (0.5-0.7 h). Absorption in the mouse was also rapid with the maximum plasma concentration occurring between 15 and 30 min after dosing. The maximum concentration was not appreciably different between male and female mice (8 μg equiv./g at 2 mg/kg; ∼350 μg equiv./g at 100 mg/kg). The primary route of elimination was via the urine. PFHx was not metabolized in rat or mouse hepatocytes, nor were any metabolites observed after oral dosing in either rodent species. Essentially 100% of the dose was eliminated in urine within 24 h demonstrating that PFHx is readily absorbed and bioavailability approaches 100%, even at a dose as high as 100 mg/kg. The route and extent of elimination was unchanged after 14 days of daily dosing. Tissues were collected at three time points (rat: 0.5, 2, and 24 h; mice: 0.25, 1, and 24 h) after dosing to investigate the tissue clearance kinetics of PFHx following a single dose at 2 or 100 mg/kg. In all tissues except skin, PFHx was not quantifiable 24 h after dosing in both sexes of the two species. 相似文献
158.
159.
8:2 fluorotelomer alcohol: a one-day nose-only inhalation toxicokinetic study in the Sprague-Dawley rat with application to risk assessment 总被引:1,自引:0,他引:1
8:2 fluorotelomer alcohol (8:2 FTOH) inhalation exposure was investigated to (1) compare plasma metabolites to oral data, (2) conduct a route-to-route extrapolation (oral to inhalation), (3) develop a human equivalent air concentration (HEC) from a 90-day oral sub-chronic study in rats using BMD analysis, and (4) calculate a margin of exposure (MOE) between the HEC and measured air concentrations. Male and female rats were exposed nose-only for 6h at 3 or 30mg/m(3). Blood was collected at 1, 3 and 6h during exposure and 6 and 18h post exposure. Alcohol, perfluorocarboxylic acid and polyfluorinated acid metabolites were determined in plasma by LC-MS/MS. 8:2 FTOH was 相似文献
160.
Pfister BJ Gordon T Loverde JR Kochar AS Mackinnon SE Cullen DK 《Critical reviews in biomedical engineering》2011,39(2):81-124
Damage to the peripheral nervous system is surprisingly common and occurs primarily from trauma or a complication of surgery. Although recovery of nerve function occurs in many mild injuries, outcomes are often unsatisfactory following severe trauma. Nerve repair and regeneration presents unique clinical challenges and opportunities, and substantial contributions can be made through the informed application of biomedical engineering strategies. This article reviews the clinical presentations and classification of nerve injuries, in addition to the state of the art for surgical decision-making and repair strategies. This discussion presents specific challenges that must be addressed to realistically improve the treatment of nerve injuries and promote widespread recovery. In particular, nerve defects a few centimeters in length use a sensory nerve autograft as the standard technique; however, this approach is limited by the availability of donor nerve and comorbidity associated with additional surgery. Moreover, we currently have an inadequate ability to noninvasively assess the degree of nerve injury and to track axonal regeneration. As a result, wait-and-see surgical decisions can lead to undesirable and less successful "delayed" repair procedures. In this fight for time, degeneration of the distal nerve support structure and target progresses, ultimately blunting complete functional recovery. Thus, the most pressing challenges in peripheral nerve repair include the development of tissue-engineered nerve grafts that match or exceed the performance of autografts, the ability to noninvasively assess nerve damage and track axonal regeneration, and approaches to maintain the efficacy of the distal pathway and targets during the regenerative process. Biomedical engineering strategies can address these issues to substantially contribute at both the basic and applied levels, improving surgical management and functional recovery following severe peripheral nerve injury. 相似文献