卡尔曼滤波滴定分析法:苯扎溴铵的测定

研究了卡尔曼滤波及平滑在滴定分析中的应用,该法对热力学平衡及非平衡(动力学)体系均能适应;特别是对非平衡滴定,当许多其它方法误差较大或无法使用时,卡尔曼滤波法仍可获得正确的结果。已用于苯扎溴铵的硝酸银电位滴定分析与快速测定。     

法莫替丁片的溶出度与生物利用度

采用溶出度自动测试系统测定了法莫替丁片的溶出度,15min平均累积溶出97.40±0.31%。6名志愿健康受试者口服法莫替丁片40mg后,用HPLC柱切换技术测定其血药浓度,将不同血药浓度对时间的数据进行曲线拟合,计算值与实测值比较,可用一室模型描述。以统计矩计算得T_1/2=2.92h,与口服溶液相比,F_rel=118.8%。     

高交联聚乙烯与钴铬合金和陶瓷股骨头匹配使用的磨损和蠕变

髋关节骨关节炎患者进行金属对超高分子量聚乙烯(ul tra-high molecular weight polyethylene,UHMWPE)的全髋关节置换是二十世纪最为成功的外科手术之一.据文献报道使用UHMWPE衬垫的骨水泥假体20年成功率达到75%以上[1].     

The Next Wave: Confexting

Radiology conferences enable participants the opportunity to ask experts questions through question and answer (Q and A) sessions or individually. Given the time limitations and intimidating circumstances, we incorporated conference text messaging (confexting) as a method of increasing interactivity between the audience and speakers. During a 5-day radiology conference, text messaging was utilized for anonymous interactivity between the audience and speakers during Q and A sessions. There were 324 text messages; 76 of these were either follow-up statements or questions related to earlier text messages. Forty-two questions were submitted via paper notes. There was a general trend of an increasing number of text messages and a decreasing number of paper notes. The anonymous text messaging system was found to be an effective method for interactivity between the audience and the speakers. The questions and answers could be presented in a PowerPoint format at the formal Q and A sessions. Questions texted to the authors during their talks could be immediately answered or addressed in subsequent talks. Although difficult for some individuals to embrace technology, confexting allows for interactivity and prompts discussion. Confexting is an effective method for interactivity between the audience and speakers not previously utilized in a conference setting. The anonymity and asynchronous communication enable conference participants to submit more questions than in the traditional setting. The speakers may be able to explain more thoroughly difficult concepts more thoroughly with additional slides at Q and A sessions or may immediately answer texted questions during their talks.     

The role of palliative care in advanced muscular dystrophy and spinal muscular atrophy

OBJECTIVE: This study examines the potential role for palliative care services in the care of individuals with muscular dystrophy and spinal muscular atrophy, and the support of their families. METHODOLOGY: Semistructured interviews were conducted in South Australia with nine bereaved and four current family members of individuals with muscular dystrophy or spinal muscular atrophy. Issues explored during interview included: (i) the family perceptions of the difficulties in caring; (ii) the psychological and physical resources which were available to assist them; and (iii) family recall of the management of the terminal phase of the illness. RESULTS: Significant issues identified included: (i) a lack of coordination of care and access to skilled, competent carers; (ii) a lack of support for siblings; (iii) inadequate bereavement care; and (iv) limited discussion of options of ventilatory support and advance directives. CONCLUSIONS: The terminal care for individuals with muscular dystrophy and spinal muscular atrophy and their families requires improvement. Although many individuals with these conditions will die following an acute event, palliative care services may be appropriate for those who require a period of terminal care at home.     

炎宁冲剂的抗炎与解热作用研究

目的：研究炎宁冲剂的抗炎与解热作用。方法：采用角叉菜胶致大鼠足跖炎性肿胀。二甲苯致小鼠耳毛细血管通透性增高,以及大鼠皮下羧甲基纤维素囊中白细胞出游等急性炎症模型研究炎宁冲剂的抗炎作用。采用啤酒酵母液引起家兔发热的方法研究炎宁冲剂的解热作用。结果：炎宁冲剂对以上实验动物均具有明显的抗炎和解热作用。结论：炎宁冲剂对急性炎症具有明显的抗炎作用。对啤酒酵母液引起家兔发热具有明显解热作用。