全文获取类型
收费全文 | 409586篇 |
免费 | 25678篇 |
国内免费 | 2985篇 |
专业分类
耳鼻咽喉 | 5415篇 |
儿科学 | 8825篇 |
妇产科学 | 10529篇 |
基础医学 | 57080篇 |
口腔科学 | 12547篇 |
临床医学 | 32228篇 |
内科学 | 85914篇 |
皮肤病学 | 9036篇 |
神经病学 | 29417篇 |
特种医学 | 14905篇 |
外国民族医学 | 82篇 |
外科学 | 66209篇 |
综合类 | 10082篇 |
现状与发展 | 1篇 |
一般理论 | 64篇 |
预防医学 | 18427篇 |
眼科学 | 9800篇 |
药学 | 33073篇 |
1篇 | |
中国医学 | 2302篇 |
肿瘤学 | 32312篇 |
出版年
2021年 | 3270篇 |
2019年 | 3236篇 |
2018年 | 5149篇 |
2017年 | 3932篇 |
2016年 | 4094篇 |
2015年 | 4673篇 |
2014年 | 6508篇 |
2013年 | 8331篇 |
2012年 | 11548篇 |
2011年 | 11851篇 |
2010年 | 7113篇 |
2009年 | 6573篇 |
2008年 | 10868篇 |
2007年 | 11817篇 |
2006年 | 11726篇 |
2005年 | 10819篇 |
2004年 | 10379篇 |
2003年 | 10016篇 |
2002年 | 9709篇 |
2001年 | 29117篇 |
2000年 | 29578篇 |
1999年 | 24472篇 |
1998年 | 5587篇 |
1997年 | 4602篇 |
1996年 | 4137篇 |
1995年 | 3759篇 |
1994年 | 3378篇 |
1993年 | 3075篇 |
1992年 | 16577篇 |
1991年 | 15314篇 |
1990年 | 14588篇 |
1989年 | 14445篇 |
1988年 | 13005篇 |
1987年 | 12449篇 |
1986年 | 11503篇 |
1985年 | 10686篇 |
1984年 | 7183篇 |
1983年 | 5822篇 |
1982年 | 2849篇 |
1981年 | 2352篇 |
1979年 | 5673篇 |
1978年 | 3522篇 |
1977年 | 3116篇 |
1975年 | 2784篇 |
1974年 | 3190篇 |
1973年 | 2981篇 |
1972年 | 2932篇 |
1971年 | 2886篇 |
1970年 | 2615篇 |
1969年 | 2651篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
11.
P E Santos E Piontelli Y R Shea M L Galluzzo S M Holland M E Zelazko S D Rosenzweig 《Medical mycology》2006,44(8):749-753
Infections due to Penicillium species other than P.marneffei are rare. We identified a boy with X-linked chronic granulomatous disease (X-CGD) with a pulmonary nodule and adjacent rib osteomyelitis caused by Penicillium piceum. The only sign of infection was an elevated sedimentation rate. P. piceum was isolated by fine needle aspirate and from excised infected tissues. Surgical removal and one year of voriconazole treatment were very well tolerated and led to complete recovery. Microbiological, microscopic and molecular studies support the fungal diagnosis. P. piceum should be considered as a relevant pathogen in immunocompromised patients. 相似文献
12.
Yuki Asada Kazuaki Kanda Kazuyuki Ozeki Toshiro Tanaka Yohei Mizuta Shigeru Kohno 《Nihon Shokakibyo Gakkai zasshi》2006,103(12):1372-1376
Two patients with mesenteric panniculitis are presented. In the first patient, a provisional diagnosis of ileus was made, based on the clinical features and imaging data. Laparotomic findings showed that the ileum was bound tightly by a fibrous strip and dilated, with thickened and swollen mesentery. Incision of the fibrous strip was performed, and the clinical symptoms were improved. The second patient was strongly suspected to have mesenteric panniculitis, from characteristic features on abdominal computed tomography and barium enema. Conservative therapy was effective in this case. We emphasize the variety of clinical courses in mesenteric panniculitis, requiring selection of the most suitable treatment. 相似文献
13.
F. Spöler M. Först Y. Marquardt D. Hoeller H. Kurz H. Merk F. Abuzahra 《Skin research and technology》2006,12(4):261-267
BACKGROUND: Three dimensional skin equivalents are widely used in dermatopharmacological and toxicological studies and as autologous transplants in wound healing. In pharmacology, there is tremendous need for monitoring the response of engineered skin equivalents to external treatment. Transplantation of skin equivalents for wound healing requires careful verification of their quality prior to transplantation. Optical coherence tomography (OCT) is a non-contact, non-destructive imaging technique for living tissues offering the potential to fulfill these needs. This work presents an analysis of OCT for high-resolution monitoring of skin equivalents at different stages during the culture process. METHODS: We developed a high-resolution OCT imaging setup based on a commercially available OCT system. A broadband femtosecond laser light source replaces the original superluminescence diode. Tomograms of living skin equivalents were recorded with an axial resolution of 3 mum and correlated with histology and immunofluorescence images. Comparison with standard low-resolution OCT is presented to emphasize the advantages of high-resolution OCT for this application. RESULTS: OCT is particularly able to distinguish between different layers of skin equivalents including stratum corneum, epidermal and dermal layer as well as the basement membrane zone. The high-resolution OCT scans correlate closely with two key benchmarks, histology and immunofluorescence imaging. CONCLUSIONS: This study clearly demonstrates the benefits of high-resolution OCT for identifying living tissue structure and morphology. Compared with the current gold standard histology, OCT offers non-destructive tissue imaging, enabling high-resolution evaluation of living tissue morphology and structure as it evolves. 相似文献
14.
H J Kim C H Kang Y T Kim S-W Sung J H Kim S M Lee C-G Yoo C-T Lee Y W Kim S K Han Y-S Shim J-J Yim 《The European respiratory journal》2006,28(3):576-580
Although surgical lung resection could improve prognosis in some patients with multidrug-resistant tuberculosis (MDR-TB), there are no reports on the optimal candidates for this surgery. The aim of the present study was to elucidate the prognostic factors for surgery in patients with MDR-TB. Patients who underwent lung resection for the treatment of MDR-TB between March 1993 and December 2004 were included in the present study. Treatment failure was defined as greater than or equal to two of the five cultures recorded in the final 12 months of treatment being positive, any one of the final three cultures being positive, or the patient having died during treatment. The variables that affected treatment outcomes were identified through univariate and multivariate logistic regression analysis. In total, 79 patients with MDR-TB were included in the present study. The treatment outcomes of 22 (27.8%) patients were classified as failure. A body mass index <18.5 kg x m(-2), primary resistance, resistance to ofloxacin and the presence of a cavitary lesion beyond the range of the surgical resection were associated with treatment failure. Low body mass index, primary resistance, resistance to ofloxacin and cavitary lesions beyond the range of resection are possible poor prognostic factors for surgical lung resection in multidrug-resistant tuberculosis patients. 相似文献
15.
16.
S F Wong A Lee-Tannock D Amaraddio F Y Chan H D McIntyre 《Ultrasound in obstetrics & gynecology》2006,28(7):934-938
OBJECTIVE: To assess the effect of glucose control on the rate of growth of fetuses in women with pregestational diabetes mellitus (Types 1 and 2). METHODS: All pregestational diabetic women booked at Mater Mothers' Hospital, Brisbane, Australia, between 1 January 1994 and 31 December 2002, were included. Pregnancies with congenital fetal anomalies, multiple pregnancies, and pregnancies terminated prior to 20 weeks' gestation were excluded. Dating scans were performed before 14 weeks' gestation and serial scans were performed at 18, 24, 28, 32 and 36 weeks. Fetal parameters, including biparietal diameter, femur length and abdominal circumference, were recorded. The daily growth rates for biparietal diameter, femur length, and fetal abdominal area were calculated and compared with those in a low-risk (non-diabetic) population. The growth rates in fetuses of women with satisfactory diabetic control (HbA1c < 6.5%) and unsatisfactory control (HbA1c > or = 6.5%) in the three trimesters were compared. RESULTS: A total of 174 diabetic pregnancies were included and a total of 997 ultrasound scans were performed. The growth rates for fetuses of mothers with diabetes mellitus were significantly higher than for those in the low-risk population. The z-scores for biparietal diameter, femur length, and fetal abdominal area were 0.18, 0.59 and 1.44, respectively. Fetuses of diabetic mothers with high HbA1c in the first trimester had significantly greater fetal abdominal area growth rate than those with normal HbA1c (fetal abdominal area z-score of 1.7 vs. 0.75, P = 0.009). Although the fetal abdominal area z-scores in fetuses of diabetic mothers with high HbA1c in the second or third trimesters were also higher than those with normal HbA1c levels, the differences did not reach statistical significance. Maternal obesity did not influence the fetal growth rate. CONCLUSION: The rate of growth of fetuses of diabetic mothers differs from that of the normal population. Growth acceleration persists until the late third trimester. Moreover, periconceptional glucose control appears to have a significant effect on accelerated growth of the fetal abdominal area. 相似文献
17.
Chan C. H. Y Ng E. H. Y Chan C. L W 《世界核心医学期刊文摘》2006,2(6):15-15
目的:评价东部身体-智力-精神(EBMS)群体干预对进行体外受精(IVF)的中国妇女焦虑缓解的作用。设计:随机对照研究。机构:三级辅助生殖机构。受试者:227例接受第1个IVF周期治疗的妇女。干预:干预组(n=69)接受4次EBMS群体咨询,而对照组(n=115)无任何干预。主要观察指标:状态-特质焦虑问卷。结果:与对照组相比,干预组在干预后状态焦虑平均分显著下降。每组移植同样数目的卵子,但干预组没有明显更高妊娠率的倾向。 相似文献
18.
Hiroto Egawa Koichi Tanaka Mureo Kasahara Yasutsugu Takada Fumitaka Oike Kohei Ogawa Seisuke Sakamoto Koichi Kozaki Kaoru Taira Takashi Ito 《Liver transplantation》2006,12(10):1512-1518
Living donor liver transplantation (LDLT) for patients with portal vein thrombosis (PVT) involves technical difficulty. The aim of this research was to analyze their preoperative diagnosis of PVT, operative procedures, and postoperative courses of patients with preoperative PVT. Thirty-nine patients of 404 adult patients (9.7%) undergoing LDLT in our hospital from 1996 June to 2004 December had PVT at their transplantation. Twenty-nine patients had intractable ascites, 21 had gastrointestinal bleeding, and 18 had encephalopathy. The thrombus was located in the portal trunk in 23, in the portal trunk and superior mesenteric vein (SMV) in 7, and developed into the SMV and the splenic vein in 8. The occlusive grade was partial in 29, and complete in 10 patients. The thrombus was removed by a simple technique, and eversion and/or incision technique, or total removal of the portal vein (PV). The PV was reconstructed with the thrombectomized native PV, with an interposed vein graft, or porto-caval hemitransposition. Advanced PVT had a significant impact on blood loss and hospital mortality. Three out of 10 patients with residual PVT required radiological and/or surgical intervention after transplantation. In conclusion, thorough planning is essential for a successful LDLT outcome for patients with preexisting PVT. 相似文献
19.