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51.
Igaki N Takashima M Ohyama M Oh S Kida A Yanase K Sakai M Tamada F Goto T 《Clinical and experimental nephrology》2004,8(2):163-167
We report the beneficial effect of control of anemia on hyperinsulinemia and hypoxemia in a hemodialysis patient with corrected transposition of the great arteries. The patients hemoglobin (Hb) level of 10.3g/dl on admission represents good control for hemodialysis (HD) patients, but it was too low for this patient with secondary polycythemia because of a right-to-left shunt. Control of anemia for a 10-month period was followed by a marked increase in Hb level (from 10.3g/dl to 13.9g/dl) and in aerobic work capacity, while the fasted insulin level decreased from 36.7µU/ml to 8.0µU/ml, without changes in leptin level, body mass index (BMI), fat mass, Kt/V, or protein catabolic rate (PCR). Additionally, hypoxemia was ameliorated, from PO2 33.1mmHg to PO2 56.2mmHg, and the hyperdynamic cardiac state was improved. The degree of anemia, together with deteriorating tissue oxygenation, may have predisposed this patient to developing insulin resistance and consequent hyperinsulinemia. The most appropriate target Hb concentration should be tailored for the clinical condition of each individual patient, bearing in mind an insulin-resistance state, especially in hemodialysis patients with hypoxemia. A more complete understanding of what regulates insulin resistance and consequent hyperinsulinemia in endstage renal disease (ESRD) awaits the elucidation of carbohydrate and insulin metabolism. 相似文献
52.
Tamada Y Aoki D Nozawa S Irimura T 《European journal of cancer (Oxford, England : 1990)》2004,40(1):158-163
Lymph node metastasis through the lymphatic vessels is a critical step in determining the outcome of ovarian cancer patients, and prognosis should be improved by preventing lymph node metastasis. However, experimental models for lymph node metastasis of ovarian carcinoma are not available. We developed an orthotopic transplantation model to study this process in nude mice using the human ovarian carcinoma cell lines, KF and MH. Highly metastatic sublines (KF-LN3 and MH-LN3) were selected in vivo in nude mice by repeated orthotopic transplantation, lymph node metastasis formation and culturing the tumour cells in vitro. Because this model seems to correspond to the advanced clinical stage of ovarian carcinomas, it should be useful in understanding the molecular biology of ovarian carcinomas and in the development of therapeutic modalities against lymph node metastasis. 相似文献
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Okada J Higashitsuji Y Tamada H Kawashiro O Fukuzaki T Suzuki T Itou H 《Annals of nuclear medicine》2003,17(3):235-238
A new non-invasive simple method for quantitative evaluation of thyroid was presented using graphical analysis of the transfer process of technetium-99m pertechnetate (99mTc) from the blood to thyroid. Thirty subjects were studied. After a bolus injection of 111 MBq of 99mTc, the data were recorded on a 128 x 128 matrix as 60 frames of 1.5-second duration. ROIs were placed over the aortic arch and bilateral thyroid lobes. The activity of the aorta was monitored instead of the arterial activity. Graphical analysis by plotting B(t)/A(t) versus integral(0)t A(tau)d tau/A(t) gave a straight line within the first 30 seconds in all subjects. The slope of the line was the unidirectional influx rate of 99mTc (k(u)). Thyroid perfusion index (TPI) was calculated to standardize where the ratio of ROI(thyroid) size to ROI(aorta) size was set as 10. K(u) and TPI showed good correlation with 99mTc thyroid uptake. Hyperthyroid patients showed high values of k(u) and TPI. Considering that these indices were determined at the first pass of 99mTc, this method may be helpful especially in the evaluation of thyroid perfusion. 相似文献
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Tamada T Sone T Tomomitsu T Jo Y Tanaka H Fukunaga M 《Journal of bone and mineral metabolism》2001,19(1):45-51
In the present study, we investigated the diagnostic effectiveness of biochemical markers of bone turnover for the detection
of bone metastasis from prostate cancer and changes in the levels of these markers caused by hormonal therapy. Ninety-five
patients with prostate cancer were divided into one of three groups: 26 patients with bone metastasis (BM(+)), 35 patients
without bone metastasis on nonhormonal therapy (BM(−)HT(−)) and 34 patients without bone metastasis on hormonal therapy (BM(−)HT(+)).
All patients in the BM(+) group had received hormonal therapy. Serum or urinary levels of the following biochemical markers
of bone turnover were examined: bone-specific alkaline phosphatase (B-ALP), osteocalcin (OC), type I procollagen C-propeptide
(PICP), type I collagen cross-linked C-telopeptide (ICTP), C-telopeptide fragment (CTx), N-telopeptide fragment (NTx), total
pyridinoline (T-Pyr), total deoxypyridinoline (T-D-Pyr) and free deoxypyridinoline (F-D-Pyr). The BM(+) group showed significantly
higher values than the BM(-)HT(-) group for B-ALP, PICP, NTx, CTx, T-Pyr, T-D-Pyr, and F-D-Pyr. Compared with the BM(−)HT(+)
group, the BM(+) group showed significantly higher values for B-ALP, ICTP, NTx, T-Pyr and T-D-Pyr. The levels of B-ALP, NTx,
CTx, T-D-Pyr and F-D-Pyr were significantly different between the BM(−)HT(−) and BM(−)HT(+) groups. All markers, except OC
and CTx, significantly were correlated with the extent of bone metastasis on bone scintigraphy. Of all markers, receiver operating
characteristic (ROC) analyses revealed B-ALP and F-D-Pyr to be the most sensitive and specific for differentiation between
the BM(+) and BM(−)HT(−) groups with regard to bone formation and resorption, respectively. In contrast, B-ALP and ICTP were
most sensitive and specific for differentiation between the BM(+) and BM(−)HT(+) groups. The results suggest that hormonal
therapy greatly affects the efficacy of PICP, CTx and F-D-Pyr in the diagnosis of bone metastasis, whereas its effects on
ICTP are small. Although bone metabolic markers would be useful in the diagnosis of bone metastasis from prostate cancer,
the effects of hormonal therapy on bone metabolism should be kept in mind in their evaluation.
Received: November 18, 1999 / Accepted: June 12, 2000 相似文献
57.
Tierney MJ Tamada JA Potts RO Eastman RC Pitzer K Ackerman NR Fermi SJ 《Annals of medicine》2000,32(9):632-641
The GlucoWatch (Cygnus, Inc, Redwood City, CA, USA) biographer provides automatic, frequent and noninvasive blood glucose measurements for up to 12 h. The device extracts glucose through intact skin where it is measured by an amperometric biosensor. Clinical trials in a variety of environments have shown that the biographer provides accurate and precise glucose measurements when compared with serial fingerstick blood glucose measurements. Mean difference between these measurements was 0.26 mmol/L in the home environment (r = 0.80). Over 94% of biographer readings were in the clinically acceptable A+B region of the Clarke Error Grid. A slight positive bias is observed for the biographer readings at low glucose levels. Biographer precision, as measured by coefficient of variation (CV)%, is approximately 10%. The low glucose alert function of the biographer was able to detect up to 75% of hypoglycaemic episodes with a low false alert level. Skin irritation, characterized by erythema and oedema was either nonexistent or mild in over 87% of subjects and resolved in virtually all subjects without treatment in several days. The GlucoWatch biographer has been shown to be a safe and effective method to track glucose level trends and patterns, which should enable improved glycaemic control for many patients. 相似文献
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