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排序方式: 共有8904条查询结果,搜索用时 15 毫秒
991.
Shinichiro Hanada Masaru Harada Takumi Kawaguchi Hiroto Kumemura Eitaro Taniguchi Hironori Koga Chikatoshi Yanagimoto Michiko Maeyama Takato Ueno Michio Sata 《Hepatology research》2007,37(10):828-835
Aim: Mallory bodies have been observed in various liver diseases, however, the precise mechanism and significance of these structures have yet to be determined.
Methods: Previously we reported on the redistribution of cytosolic proteins to keratin inclusions in mutant keratin 18-transfected cells. In this study, we treated green fluorescent protein-tagged wild-type keratin 18-transfected cells with several proteasome inhibitors and performed immunofluorescent analyses.
Results: Proteasome inhibitors induced intracellular keratin inclusions, and desmoplakin, zonula occludens-1 and β-catenin were relocated to keratin inclusions, while theintegral membrane proteins were intact. The cytosolic proteins, 14-3-3 ζ protein and glucose-6-phosphate dehydrogenase were also relocated to inclusions. Moreover, E-cadherin, a basolateral membrane protein, was present on both the apical and basolateral domains in inclusion-containing cells.
Conclusion: These data are identical to those in the mutant keratin 18 transfection study and suggest that keratin inclusions induced by different treatments affect localization of various cytosolic components, which may influence cellular functions performed by these proteins. 相似文献
Methods: Previously we reported on the redistribution of cytosolic proteins to keratin inclusions in mutant keratin 18-transfected cells. In this study, we treated green fluorescent protein-tagged wild-type keratin 18-transfected cells with several proteasome inhibitors and performed immunofluorescent analyses.
Results: Proteasome inhibitors induced intracellular keratin inclusions, and desmoplakin, zonula occludens-1 and β-catenin were relocated to keratin inclusions, while theintegral membrane proteins were intact. The cytosolic proteins, 14-3-3 ζ protein and glucose-6-phosphate dehydrogenase were also relocated to inclusions. Moreover, E-cadherin, a basolateral membrane protein, was present on both the apical and basolateral domains in inclusion-containing cells.
Conclusion: These data are identical to those in the mutant keratin 18 transfection study and suggest that keratin inclusions induced by different treatments affect localization of various cytosolic components, which may influence cellular functions performed by these proteins. 相似文献
992.
A patient with type 2 diabetes and hypothalamic damage due to a suprasellar tumor developed impaired glycemic control and central obesity. The patient showed exaggerated adrenocorticotropic hormone responsiveness as determined by a corticotrophin releasing hormone test and elevated serum leptin concentrations associated with ravenous appetite and insulin resistance mediated in part through disturbances in leptin signaling. Combination treatment with metformin and pioglitazone was markedly effective in improving glycemic control. Additionally, metformin treatment showed marked anorectic effects on the hyperphagia. This case has important implications for the pathogenesis and management of diabetes in patients with hypothalamic-pituitary-adrenal axis deficiencies. 相似文献
993.
Takeshi Kawaguchi Noriyoshi Sawabata Tokiko Nakai Sachiko Miura Norikazu Kawai Motoaki Yasukawa Takashi Tojo Chiho Ohbayashi Shigeki Taniguchi 《Respiratory investigation》2018,56(6):473-479
Background
Intrapulmonary lymph nodes (IPLNs) are often recognized as sub-centimeter solid pulmonary nodules (SCPNs). The present study investigated their clinical and pathological characteristics to allow clinicians to distinguish them from malignant nodules.Methods
Among 194 SCPNs surgically resected between 2006 and 2016, 26 IPLNs were investigated histopathologically. In addition, 145 resected malignant SCPNs were compared radiographically with the 26 IPLNs.Results
Radiographically, most IPLNs were in a middle or lower lobe, and all lesions were within 20?mm of the visceral pleura. Enlargement was seen in one lesion. Three lesions demonstrated linear density contiguous to pleura (LD), and 13 lesions were adjacent to the peripheral pulmonary vein (APV). Microscopically, all IPLNs showed adjacency to pulmonary veins, 23 showed interlobular septa extending from the IPLN, and 18 were surrounded by a dilatated lymphoid channel. Radiographical findings of LD and APV were also seen in malignant SCPNs (LD, 12/145; APV, 25/145). Comparative analysis revealed that enlargement and APV were significant predictors differentiating IPLNs from malignant SCPNs. The sensitivity/specificity of enlargement and APV were 92%/92% and 17%/50%, respectively.Conclusions
IPLNs show typical high-resolution computed tomography findings that reflect their histopathological characteristics. Such findings help identify IPLNs prior to surgery. Specifically, enlargement and APV may differentiate IPLNs from malignant SCPNs. However, atypical cases are also possible, and radiological findings are not specific for differentiating IPLNs from malignant lesions. Thus, clinicians should consider surgical exploration when diagnosing SCPNs. 相似文献994.
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells 总被引:4,自引:0,他引:4
995.
996.
Masanori Tanaka Atsuhiko Saitoh Takeo Narita Yuuki Hizawa Hideo Nakazawa Norimasa Narita Hajime Kudo 《Journal of gastroenterology》1994,29(2):199-202
Tightly coiled spiral micro-organisms (Gastrospirillum hominis), distinct fromHelicobacter pylori, were found in the gastric mucosa of a 66-year-old man with a 4-month history of intermittent epigastric pain. The organisms
were distributed in the antral mucosa, which showed erosive gastritis; histologically, the affected mucosa presented moderate
to severe chronic gastritis with focal neutrophil infiltration. After a 2-week administration of cimetidine, his symptoms
resolved and the active inflammation was reduced, both endoscopically and histologically, but the organisms still remained.
Biopsy specimens taken 4 weeks after treatment with minocycline and cimetidine showed normal gastric mucosa without the spiral
organisms. The above clinical course suggests the possible role ofGastrospirillum hominis in the pathogenesis of gastritis. 相似文献
997.
Masau?Sekiguchi Ryoji?KushimaEmail author Ichiro?Oda Haruhisa?Suzuki Hirokazu?Taniguchi Shigeki?Sekine Takeo?Fukagawa Hitoshi?Katai 《Journal of gastroenterology》2015,50(4):424-434
Background
We recently reported that the presence of a papillary adenocarcinoma (pap) component was an independent risk factor for lymphatic involvement in endoscopically resected early gastric cancer (EGC). This study aimed to investigate the potential association between the presence of a pap component in EGC and lymph node metastasis (LNM).Methods
In order to evaluate the association between LNM and clinicopathological features, including a pap component, we reviewed 628 surgically resected EGCs at our institution between 2009 and 2012. Clinicopathological features included age, gender, tumor location, macroscopic type, tumor size, histological type, depth, ulcerative findings, and lymphatic and venous involvement. In addition, the association between clinicopathological features and lymphatic involvement was also evaluated.Results
LNM was observed in 52 cases (8.3%). Univariate analyses revealed a significant correlation between a pap component and LNM as well as tumor size, depth, macroscopic type, a poorly differentiated adenocarcinoma component, and lymphatic and venous involvement. The percentage of positive LNM among the EGC cases with a pap component was significantly higher than in those without the component (18.2 vs. 7.3%, P = 0.010). Via multivariate analyses lymphatic involvement was identified as the strongest risk factor for LNM [odds ratio (OR) 14.1] and a pap component was revealed as an independent risk factor for lymphatic involvement (OR 3.1).Conclusion
Our study revealed that EGC cases with a pap component were at higher risk of lymphatic involvement and showed a higher percentage of positive LNM. More attention should be paid to a pap component in EGC.998.
Synthetic lethal interaction of combined CD26 and Bcl‐xL inhibition is a powerful anticancer therapy against hepatocellular carcinoma
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999.
Long‐term mild‐intensity exercise regimen preserves prefrontal cortical volume against aging
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1000.
Daisuke Jitoku Naoki Yamamoto Yoshimi Iwayama Tomoko Toyota Momo Miyagi Takeshi Enokida Yuri Tasaka Masakazu Umino Asami Umino Akihito Uezato Yasuhide Iwata Katsuaki Suzuki Mitsuru Kikuchi Tasuku Hashimoto Nobuhisa Kanahara Akeo Kurumaji Takeo Yoshikawa Toru Nishikawa 《Journal of neural transmission (Vienna, Austria : 1996)》2015,122(6):915-923