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101.
F. Yıldız M.D B. Kelle M.D D.A. Taş M.D B. Kaya M.D E. Altun M.D E. Erken M.D 《Zeitschrift für Rheumatologie》2014,73(8):754-757
The systemic disorder of mineral and bone metabolism which is related to chronic kidney disease (CKD) is called mineral and bone disorder (MBD). Calcifications related to CKD-MBD may occur in ophthalmic tissue, arterial walls, subcutaneous and periarticular soft tissues and organs. The vascular calcifications are the most important causes of mortality and morbidity in CKD. Here, we present a case of systemic lupus erythematosus with early and disseminated calcifications of vascular and periarticular soft tissues related to CKD-MBD. 相似文献
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T. M. L. Huynh B. H. Nguyen V. G. Nguyen H. A. Dang T. N. Mai T. H. G. Tran M. H. Ngo V. T. Le T. N. Vu T. K. C. Ta V. H. Vo H. K. Kim B. K. Park 《Transboundary and Emerging Diseases》2014,61(6):e25-e34
This study demonstrated the prevalence of Porcine circovirus type 2 (PCV2) among pig farms in Vietnam. Analyses of the genome, capsid protein and phylogeny classified all 30 Vietnamese PCV2 strains as the PCV2b genotype, belonging to the clusters of 1A, 1B, 1C and recombinant forms. Each viral genome was 1767 nucleotides long and shared 96.0–100% nucleotide sequence identity. The amino acid substitutions in the capsid protein of the Vietnamese PCV2 strains were in immunodominant regions, and the majority of strains (24/30) contained a lysine extension at the C‐terminus. Bayesian phylogeographic analysis revealed epidemic links of the PCV2 recombinant cluster within and among countries, which supports a circulating recombinant form of PCV2. Further analysis by the Jameson–Wolf antigenic index indicated antigenic alterations at important sites in the capsid protein (sites 131–133) among the recombinant cluster and the other clusters of PCV2b. 相似文献
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Cengiz Candan Nur Canpolat Selman Gökalp Nurdan Yıldız Pınar Turhan Mehmet Taşdemir Lale Sever Salim Çalışkan 《Pediatric nephrology (Berlin, Germany)》2014,29(1):95-102
Background
The aim of this study was to evaluate the presence of subclinical cardiovascular disease (CVD) and its relation to risk factors in pediatric patients with steroid-resistant nephrotic syndrome (NS).Methods
Thirty-seven patients with normal renal function were compared with 22 healthy controls regarding the presence of subclinical CVD. Measurements included aortic pulse wave velocity (PWV), carotid intima media thickness (IMT), and left ventricular mass (LVM). Patients were additionally assessed for blood pressure (BP) pattern and the presence of hypertension by 24-h ambulatory blood pressure monitoring.Results
Compared with the controls, patients had significantly higher mean aortic PWV-standard deviation scores (SDS), mean carotid IMT-SDS, and LVM index (p?<?0.001 for all). Increased aortic PWV was noted in 5 % of patients, increased carotid IMT in 22 %, and increased LVM index in 19 %. Five patients (14 %) were hypertensive, and mean BP indexes, SDS, and BP loads during nighttime were significantly higher than those during daytime (p?<?0.001 for all). Multivariate analysis revealed a significant relationship between PWV-SDS and ferritin (R 2?=?0.269, p?=?0.006) and between carotid IMT-SDS and proteinuria (R 2?=?0.141, p?=?0.022). The LVM index was independently associated only with higher body mass index SDS (R 2?=?0.317, p?<?0.001). In addition, six patients (16 %) had multiple abnormal subclinical CVD markers, and increased subclinical CVD risk was independently associated only with higher low-density lipoprotein cholesterol (R 2?=?0.292, p?=?0.044).Conclusions
Based on these results, steroid-resistant NS children generally are at high risk of cardiovascular complications, but the increased risk is likely to be multifactorial. 相似文献105.
Shi-yuan Yu Yan-xia Gao Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li 《世界急诊医学杂志(英文)》2020,11(1):37-47
BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. 相似文献
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Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I
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A. Wollenberg S. Barbarot T. Bieber S. Christen‐Zaech M. Deleuran A. Fink‐Wagner U. Gieler G. Girolomoni S. Lau A. Muraro M. Czarnecka‐Operacz T. Sch?fer P. Schmid‐Grendelmeier D. Simon Z. Szalai J.C. Szepietowski A. Ta?eb A. Torrelo T. Werfel J. Ring the European Dermatology Forum the European Academy of Dermatology Venereology the European Academy of Allergy Clinical Immunology the European Task Force on Atopic Dermatitis European Federation of Allergy Airways Diseases Patients’ Associations the European Society for Dermatology Psychiatry the European Society of Pediatric Dermatology Global Allergy Asthma European Network the European Union of Medical Specialists 《Journal of the European Academy of Dermatology and Venereology》2018,32(5):657-682
This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus‐based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti‐inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen‐specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions. Management of AE must consider the individual clinical variability of the disease; highly standardized treatment rules are not recommended. Basic therapy is focused on treatment of disturbed barrier function by hydrating and lubricating topical treatment, besides further avoidance of specific and unspecific provocation factors. Topical anti‐inflammatory treatment based on glucocorticosteroids and calcineurin inhibitors is used for flare management and for proactive therapy for long‐term control. Topical corticosteroids remain the mainstay of therapy, whereas tacrolimus and pimecrolimus are preferred in sensitive skin areas and for long‐term use. Topical phosphodiesterase inhibitors may be a treatment alternative when available. Adjuvant therapy includes UV irradiation, preferably with UVB 311 nm or UVA1. Pruritus is targeted with the majority of the recommended therapies, but some patients may need additional antipruritic therapy. Antimicrobial therapy, systemic anti‐inflammatory treatment, immunotherapy, complementary medicine and educational intervention will be addressed in part II of the guideline. 相似文献
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目的 探讨四肢战创伤病例中院内死亡的死亡原因及危险因素.方法 对1968年至2002年在战伤救治过程中收治的352例四肢战创伤病例进行回顾性研究,对15例死亡病例尸体剖解结果进行分析以探讨其死亡原因,并采用logistic回归模型对死亡的危险因素进行了多因素统计学分析.以探讨影响死亡的危险因素.结果 352例在院病例中死亡15例,病死率为4.3%.死亡原因主要有急性肾功能衰竭(ARF)7例(46.7%),肺栓塞3例(20.0%),多器官功能衰竭(MOSF)2例(13.3%),气性坏疽3例(20.0%),其中气性坏疽合并ARFl例,合并MOSF 1例.死亡的主要危险因素有:休克、截肢(χ2=93.589、144.716,均P<0.05).结论 四肢战创伤病例主要死亡原因为ARF,对休克病人的及时正确处理以及截肢时机的正确选择有利于减少死亡率. 相似文献