An open add-on study on cyclophosphamide in patients with refractory myasthenic crisis

Objective: To assess the efficacy and side effects of cyclophosphamide on refractory myasthenic crisis. Methods: Five patients of myasthenic crisis refractory to usual comprehensive treatment, entered an open additional study with cyclophosphamide 200 mg VD q. d or 400 mg VD q. o. d with 6-10 g of total dosage. The patients were followed up for 1-8 years. Results: All the 5 patients were effectively treated with obvious remission in 3 and improvement in 2. Two patients have returned to partial work. The side effects were tolerable. Conclusion: The present clinical trial showed that cyclophosphamide was effective, particularly in a long term as an additional therapy for treating MG patients with refractory crisis of myasthenia gravis.     

胸腔镜下胸交感神经干切断术治疗手汗症(附300例报告)

目的总结胸腔镜胸交感神经干切断术300例的临床经验。方法分析2003年1月至2006年1月经胸腔镜胸交感神经干T_2～T_4切断术治疗手汗症的临床资料。以患侧手掌皮肤温度较术前升高1℃～3℃或更高,转干燥者为有效。手掌皮肤温度较术前增加小于1℃仍为潮湿者为无效。结果300例手术均获成功,术后患者手掌多汗症状消失,双手转为干燥温暖状,术后掌温升高(2.8±0.8)℃;282例术后随访1～36个月无一例复发,术后转移代偿性多汗60例占21.2%。结论胸交感神经干切断术是治疗手汗症安全、微创和有效的方法。     

桑椹果酒酵母筛选及发酵性能

从桑椹成熟果实、桑叶以及桑果园的土壤采样，进行桑椹果酒专用酵母的筛选，得到一株在性能上优于对照菌葡萄酒干酵母的酵母菌Y11。该菌起酵快，从第2天开始糖度大幅度下降，酒精度快速上升，发酵第4天酒精体积分数即可达到10％以上。发酵过程pH值变化趋势比较平缓，发酵结束后高级醇量符合要求。综合发酵性能及感官评定，表明该菌能代替葡萄酒干酵母用于桑椹果酒的生产。     

增白牙膏去除牙面外源性色素临床实验

目的测试一种增白牙膏用于减少牙面外源性色素的效果. 方法 研究对象121例,年龄21～57岁.实验组60例,对照组61例,两组年龄和性别分布差异无显著性.采用双盲法两组平行设计,根据Lobene色斑指数(LSI)和性别均衡分为两组,随机分配使用实验牙膏或对照牙膏.实验组牙膏含3 %植酸钠和1.3 %焦磷酸钠,对照组牙膏不含相应成分.临床检查分别在基线、3周和6周后进行,由同一人测定LSI.问卷询问刷牙情况. 结果 基线检查、实验3周和6周后实验组LSI分别为3.00、2.16和1.47, 对照组分别为3.10、3.08和2.18.基线检查两组LSI差别无显著性意义, 实验3周和6周后两组LSI比较差异均有显著性意义. 实验组LSI在3周和6周后分别比基线时降低28 %和51 %. 结论含3 %植酸钠和1.3 %焦磷酸钠牙膏能有效减少牙面色素,效果随使用时间而增强.     

厄尔·迈纳的跨文化阐释

厄尔·迈纳的《比较诗学》从跨文化的角度对诗学作比较探讨 ,他以基础文类形成原创诗学为理论基础 ,以基础文类的分析作为跨文化阐释的切入点 ,以基础文类同异关系的把握作为诗学比较的可比性的基础 ,以一种宽容平等的对话精神作为跨文化阐释的态度 ,显示了比较诗学发展的一个必然的成熟过程。但科学的相对主义态度 ,注定了从事比较诗学面临着“诗学”“跨文化”“阐释”等因素的制约 ,这也同时为比较诗学的开拓提供了更多的空间。     

Psychoactive substance use in three sites in China: gender differences and related factors

One year prevalence rates far psychoactive substance use are reported based on a community survey in Hunan, Helongjiang and Jiangsu. Data were gathered on more than 14 000 respondents (15–65 years old). The drinking rates ranged from 58.3% to 82.6% for men and from 16.3% to 31.4% for women. Smoking rates ranged from 64.9% to 68.1% for men and from 0.1% to 20.5% for women. Most drinkers were light users and most smokers were heavy users, Illicit drug use was found in the Hunan site. For both frequency and quantity of psychoactive substance use, women are lighter consumers than males (except for the use of minor tranquilizers and analgesics). Psychosocial factors related to drinking and smoking are also investigated in this study.     

Analysis of the Neutralizing Antibody Response to the Measles Virus Using Synthetic Peptides of the Haemagglutinin Protein

Infection or immunization with measles virus induces a protective immune reaction including neutralizing antibodies against the haemagglutinin and fusion protein. The reactivity of the polyclonal IgG response of sera obtained from late convalescent donors was studied, using overlapping 15mer peptides covering the complete sequence of the measles virus haemagglutinin. Most sera reacted with a similar set of peptides generating a characteristic binding pattern. The reactive peptides correspond to a region mediating cell hemolysis (aa310–325), to regions which serve as targets to neutralizing antibodies and to a putative transmembrane region (aa35–58). The latter region contains also a human T-cell epitope providing evidence of a non-random association of T- and B-cell epitopes. We also immunized different strains of mice and rabbits with measles virus. In contrast to the human sera, animal sera with strong neutralizing activities did not react with any of the H-protein peptides. The mostly weak reactivities with the linear sequences contrast with the strong neutralizing activities of the human or animal antibodies, suggesting that these primarily recognize the fusion protein or conformational epitopes of the haemagglutinin protein.     

重组人干扰素α-2b鼻腔喷雾剂预防治疗恒河猴感染SARS-CoV的试验研究

目的评价重组人干扰素α-2b鼻腔喷雾剂对恒河猴感染SARS-CoV的预防治疗作用。方法采用鼻腔喷雾法(剂量为60万单位/鼻孔)研究了重组人干扰素α-2b鼻腔喷雾剂对感染SARS-CoV的恒河猴预防治疗效果。结果试验组(5只)和对照组(5只)相同时间检测的咽拭子等标本中,Real-time PCR检测和病毒分离均未检出病毒。攻毒后病毒导致机体产生的中和抗体和IgG抗体的反应也较对照组弱。血液学指标检测结果表明试验组动物攻毒后各项指标较试验前比较没有显著性改变;病理结果显示试验组2只恒河猴肺组织形态基本正常,其余3只猴有肺间质性炎,表现肺间隔增厚、单核样细胞为主的炎细胞浸润,其中1只增厚的肺间隔有局灶相互融合,这3只猴肺部病变与对照组的病变表现相似,且病变累及范围较对照组小;其他各受检脏器均未见明显异常。结论重组人干扰素α-2b鼻腔喷雾剂可以有效阻断或减弱SARS-CoV对恒河猴的感染。     

三个价型六种盐对C8-卵磷脂胶团溶液液相分离影响的研究

本文研究三个价型六种盐对C_8-卵磷脂微团溶液的液-液相分离调控的规律,测定出各种加盐溶液的两相共存曲线,获得了各系统相变临界温度T_c随盐类型和盐离子强度变化的关系。用我们先前导出的关于盐对该微团溶液相变影响关系的方程式为T_c=T~0_c-A_1[I]~1.2+A_2[I]对本实验结果的拟合表明,这六种加盐微团溶液的液-液相分离亦遵从同样的变化规律。从而为揭示各种价型无机盐对两性离子化表面活性物质微团溶液液相分离的作用规律和机制提供了进一步的实验与理论依据。