全文获取类型
收费全文 | 12234篇 |
免费 | 832篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 86篇 |
儿科学 | 389篇 |
妇产科学 | 235篇 |
基础医学 | 2014篇 |
口腔科学 | 280篇 |
临床医学 | 1196篇 |
内科学 | 2177篇 |
皮肤病学 | 341篇 |
神经病学 | 1656篇 |
特种医学 | 484篇 |
外科学 | 1014篇 |
综合类 | 62篇 |
一般理论 | 4篇 |
预防医学 | 894篇 |
眼科学 | 369篇 |
药学 | 839篇 |
中国医学 | 22篇 |
肿瘤学 | 1034篇 |
出版年
2024年 | 19篇 |
2023年 | 115篇 |
2022年 | 181篇 |
2021年 | 303篇 |
2020年 | 246篇 |
2019年 | 270篇 |
2018年 | 340篇 |
2017年 | 296篇 |
2016年 | 399篇 |
2015年 | 425篇 |
2014年 | 520篇 |
2013年 | 684篇 |
2012年 | 965篇 |
2011年 | 973篇 |
2010年 | 555篇 |
2009年 | 542篇 |
2008年 | 865篇 |
2007年 | 856篇 |
2006年 | 797篇 |
2005年 | 754篇 |
2004年 | 664篇 |
2003年 | 599篇 |
2002年 | 559篇 |
2001年 | 109篇 |
2000年 | 88篇 |
1999年 | 103篇 |
1998年 | 120篇 |
1997年 | 110篇 |
1996年 | 90篇 |
1995年 | 72篇 |
1994年 | 50篇 |
1993年 | 46篇 |
1992年 | 46篇 |
1991年 | 41篇 |
1990年 | 18篇 |
1989年 | 15篇 |
1988年 | 26篇 |
1987年 | 23篇 |
1986年 | 28篇 |
1985年 | 18篇 |
1984年 | 18篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 11篇 |
1980年 | 12篇 |
1979年 | 17篇 |
1978年 | 12篇 |
1976年 | 9篇 |
1975年 | 6篇 |
1974年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
D. J. Schendel Ralph Oberneder Christine S. Falk Petra Jantzer Susanne Kressenstein Barbara Maget Alfons Hofstetter Gert Riethmüller Elfriede Nößner 《Journal of molecular medicine (Berlin, Germany)》1997,75(6):400-413
Renal cell carcinomas belong to the small group of tumors that are able to induce antitumor responses. Here we describe two
general types of cytotoxic effector lymphocytes that can eliminate autologous tumor cells and discuss the role that major
histocompatibility complex encoded molecules play in governing their specificities. Improved understanding of the cellular
and molecular basis of renal cell carcinoma recognition opens new avenues of research with the potential to develop better
immunotherapies for patients with metastatic disease.
Received: 24 July 1996 / Accepted: 1 November 1996 相似文献
92.
Tardivel A Tinel A Lens S Steiner QG Sauberli E Wilson A Mackay F Rolink AG Beermann F Tschopp J Schneider P 《European journal of immunology》2004,34(2):509-518
The TNF family ligand B cell-activating factor (BAFF, BLyS, TALL-1) is an essential factor for B cell development. BAFF binds to three receptors, BAFF-R, transmembrane activator and CAML interactor (TACI), and B cell maturation antigen (BCMA), but only BAFF-R is required for successful survival and maturation of splenic B cells. To test whether the effect of BAFF is due to the up-regulation of anti-apoptotic factors, TACI-Ig-transgenic mice, in which BAFF function is inhibited, were crossed with transgenic mice expressing FLICE-inhibitory protein (FLIP) or Bcl-2 in the B cell compartment. FLIP expression did not rescue B cells, while enforced Bcl-2 expression restored peripheral B cells and the ability to mount T-dependent antibody responses. However, many B cells retained immaturity markers and failed to express normal amounts of CD21. Marginal zone B cells were not restored and the T-independent IgG3, but not IgM, response was impaired in the TACI-IgxBcl-2 mice. These results suggest that BAFF is required not only to inhibit apoptosis of maturating B cells, but also to promote differentiation events, in particular those leading to the generation of marginal zone B cells. 相似文献
93.
94.
95.
N. Matamoros Florí J. Mila Llambi T. Español Boren S. Raga Borja G. Fontan Casariego 《Journal of clinical immunology》1997,17(4):333-339
The Spanish Registry for Primary Immunodeficiency Diseases (REDIP) was organized in 1993. One thousand sixty-nine cases of primary immunodeficiency diseases (PID) were registered in patients diagnosed between January 1980 and December 1995. PID diagnosis was made according to the World Health Organization criteria. The most frequent disorders were IgA deficiency (n = 394) and common variable immunodeficiency (n = 213), followed by severe combined immunodeficiency (n = 61), C1 inhibitor deficiency (n = 52), X-Iinked agammaglobulinemia (n = 49), IgG subclass deficiency (n = 48), and chronic granulomatous disease (n = 32). A comparative study between REDIP and data recently obtained from the European registry (ESID Report, 1995) revealed important differences between phagocytic disorders and complement deficiencies reported in both registries, 4.9 vs 8.7 and 6.0 vs 3.6, while percentages of predominantly antibody deficiencies and T cell and combined deficiencies concurred with those reported in the European registry, 69.3 vs 64.7 and 14.7 vs 20.2, respectively. The heterogeneous nature of the geographical distribution of cases submitted may indicate underdiagnosis of PID in some country areas; surprisingly, the interval between the onset of clinical symptoms and diagnosis was significant, even in immunodeficiency diseases, such as IgA deficiency, which are easy to diagnose. 相似文献
96.
Gyrgy Stuber Gerhard H. Leder Walter J. Storkus Michael T. Lotze Susanne Modrow Lszl Szkely Hans Wolf Eva Klein Klas Krre George Klein 《European journal of immunology》1994,24(3):765-768
Mutations of the p53 gene are the most frequently observed genetic changes in human cancers; often leading to an overexpression of the wild-type (wt) p53 protein. Demonstrable T cell reactivity against tumor cells overexpressing wt or mutant p53-derived peptides could support the application of such epitopes in cancer immunotherapies. As the binding of peptide to MHC class I molecules is a prerequisite for antigen-specific T cell recognition, we evaluated the ability of wt and mutant p53 peptides to bind to HLA-A2.1 using two independent flow cytometry-based assay systems, the T2 major histocompatibility complex (MHC) class I peptide stabilization assay (stabilization assay) and the peptide-induced MHC class I reconstitution assay (reconstitution assay). The twenty selected wt sequences each conformed to the previously reported HLA-A2.1 peptide binding motif. Seven of the wt p53 and 2/13 mutant p53 peptides derived from the previously chosen wt peptides bound to HLA-A2.1 in both the stabilization and the reconstitution assays. An additional six wt and six mutant p53 peptides, presumably exhibiting lower affinity for HLA-A2.1, were identified only in the reconstitution assay. Those p53 peptides binding HLA-A2.1 may provide useful immunogens for the generation of HLA-A2.1-restricted cytolytic T lymphocytes in vitro and in vivo. 相似文献
97.
Bronchocentric granulomatosis: a complication of allergic bronchopulmonary aspergillosis. 总被引:1,自引:0,他引:1
G Hanson N Flor I Wells H Novey S Galant 《The Journal of allergy and clinical immunology》1977,59(1):83-90
Hypersensitivity to the fungal antigens of Aspergillus fumigatus may result in a spectrum of immune injury collectively known as allergic bronchopulmonary aspergillosis (ABPA). This report describes a 14-yr-old boy who presented clinical findings consistent with ABPA,including a history of asthma, blood eosinophilia, serum precipitins, and IgE antibodies to Aspergillus fumigatus. Sputum Aspergillus, pulmonary infiltrates, and dual types I and III skin reactions to Aspergillus fumigatus were observed also. Pathology of the resected right upper lobe revealed severe bronchial destruction with the findings of bronchocentric granulomatosis. Noninvasive septate fungal hyphae compatible with Aspergillus were identified. Cultures from sputum and surgical specimens grew Aspergillus and Mycobacterium intracellulare avium. The PPD-B (purified protein derivative-Batty) intradermal skin test produced a 6 mm induration (PPD-S was negative). The patient's condition has been well controlled with prednisone and several antituberculous drugs. In addition, inflammatory and immunologic parameters have begun to return to normal. The relationship between ABa and the atypical mycobacterial infection is not clear. The association of ABPA with the severe bronchial destruction seen in bronchocentric granulomatosis is emphasized to alert physicans to this serious sequelae of ABa seen in the asthmatic. 相似文献
98.
99.
Susanne Ott Tommaso Costa Albert Herz 《Naunyn-Schmiedeberg's archives of pharmacology》1986,334(4):444-451
Summary Equilibrium binding isotherms of [3H]diprenorphine in membranes from NG 108-15 cells are consistent with a homogenous population of binding sites. Upon addition of Na+, Mg2+ and GTP, only a 2-fold reduction in affinity with a minor decrease in the number of sites is observed. Dissociation curves of [3H]diprenorphine, however, are clearly biphasic: in the absence of Na+, Mg2+ and GTP, 80% of the bound ligand dissociates slowly with at
1/2 of 100 min, and only 20% rapidly (t
1/2 4.5 min). In the presence of Mg2+, nearly all the binding is found in the slowly dissociating form. Upon the addition of either Na+ or GTP, 20–30% of the binding dissociates more rapidly. The rate constant of the rapidly dissociating form generated by Na+, however, is 2.5 times greater than that induced by the presence of GTP. Thus, the addition of both, Na+ and GTP, converts about 80% of the receptor into a very fast dissociating form (t
1/2 1.7 min).Exposure of intact cells to pertussis toxin (10 ng/ml) or treatment of membranes with N-ethyl maleimide (500 M), strongly reduces the proportion of the slowly dissociating component. Following these treatments, the effect of GTP is reduced or abolished, but that of Na+ remains unaffected.We conclude from these data that the effects of Na+ and GTP are not only distinct in site but also in mechanism of action and that there are three forms of opioid receptors that can be differentiated by their kinetic properties. The slowly dissociating receptor form requires a functional N unit. 相似文献
100.
Mak Susanne Hunt Matthew Boruff Jill Zaccagnini Marco Thomas Aliki 《Advances in health sciences education : theory and practice》2022,27(3):793-815
Advances in Health Sciences Education - Professional identity is believed to foster self-confidence and resilience in health care professionals. While literature exists describing professional... 相似文献