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151.
E. Rehn Külbs Körte Abderhalden Griesbach Christeller Heyn Lewin Tobler Finkenrath Preuss Hellwig H. Braun Schmitz Schiff Putter A. Laqueur Vaternahm Lentz Herzfeld Eckstein Edens Staehelin Zinn Deusch Weigert Emil Neisser von Jaschke Neisser Adler Sellheim Schrader Kuhn Dietrich Koch Meyer Simon Eisner Friedemann Tobias Goldstein Vogel Steiner 《Journal of molecular medicine (Berlin, Germany)》1923,2(28):1324-1332
Ohne Zusammenfassung 相似文献
152.
Müller Friedrich Martius Simon Fischer W. Rosenow Juliusberg Braun Schmitz Magnus-Alsleben Goldschmidt Fabian Friedberg Eckstein Fischer A. W. Weigert Oppenheimer Koenigsfeld Hayward Herzfeld Halberstädter Holthusen Dietrich Dietlen Peiper Dessecker Westenhöfer Flury Nick Schlesinger Tobias Loewy-Hattendorf Steiner Goldstein Naef Jahnel Henning Köllner Meesmann Preuss Igersheimer Esch Kobrak Sturmann Vogel 《Journal of molecular medicine (Berlin, Germany)》1922,1(20):1010-1021
Journal of Molecular Medicine - 相似文献
153.
Birnbaum Krexschmer Emil Neisser H. Hirschfeld Finkenrath Tobler Christeller Oppenheimer Preuss Reiss Koemigsfeld Dietrich Laqueur A. W. Fischer Buschke Flury Teleky Starkenstein Neisser Albertius Goldstein Magnus-Alsleben E. Herzfeld Edeus Schlesinger Kaufmann Eckstein Freudenberg Friedberg Zuntz Jonas Weigert Meesmann Igersheimer Steiner 《Journal of molecular medicine (Berlin, Germany)》1922,1(27):1377-1383
Ohne Zusammenfassung 相似文献
154.
肿瘤治疗存在的问题及中西医结合的研究重点 总被引:17,自引:3,他引:17
目前的肿瘤治疗主要存在以下几个问题:(1)肿瘤的过度治疗普遍存在;(2)急功近利而缺乏长远规划;(3)综合治疗缺乏合理的内涵;(4)缺少有效的个体化治疗方案;(5)对中医药的优势认识不足、发挥不够。中西医结合在肿瘤防治中大有可为,应重点围绕以下几个方面开展研究工作:(1)加强中医对恶性肿瘤基础知识的认识和研究;(2)加强中西医结合治疗肿瘤合理化、规范化方案的研究;(3)加强中西医结合治疗恶性肿瘤疗效标准的研究;(4)加强中西医结合防治肿瘤术后复发、转移的研究。 相似文献
155.
Janina Trauth Thomas Discher Moritz Fritzenwanker Can Imirzalioglu Tobias Arnold Dagmar Steiner Elvira Richter Laura Crisponi Bodo Grimbacher Susanne Herold 《Emerging infectious diseases》2022,28(7):1506
Mycobacterium genavense infection, a rare nontuberculous mycobacteria infection, occurs in heavily immunocompromised patients (i.e., those with advanced HIV disease, genetic disorders, or acquired immunologic disorders and those undergoing immunosuppressive therapy). We report a case of disseminated M. genavense infection preceding Hodgkin lymphoma in a patient without obvious risk factors for this infection. 相似文献
156.
157.
Eimear C Morrissey Sean F Dinneen Michelle Lowry Eelco JP de Koning Marleen Kunneman 《Journal of diabetes investigation.》2022,13(8):1294
Young adults living with type 1 diabetes often struggle to achieve what clinicians consider to be optimal levels of metabolic control. Despite the impact that this can have on a young person''s future risk of complications, there are relatively few studies reporting new ways of organizing or delivering care to this cohort. In this article, we explore some of the reasons why young adult diabetes care is challenging, and describe approaches to “re‐imagining” how care might be improved. The work is informed by the ‘Making Care Fit’ collaborative and by a program of research, entitled D1 Now, involving co‐design of a complex person‐centered intervention with young adults. 相似文献
158.
Franz Buchegger Valentina Garibotto Thomas Zilli Laurent Allainmat Sandra Jorcano Hansjörg Vees Olivier Rager Charles Steiner Habib Zaidi Yann Seimbille Osman Ratib Raymond Miralbell 《European journal of nuclear medicine and molecular imaging》2014,41(1):68-78
Purpose
18F-Fluorocholine (FCH) and 11C-acetate (ACE) PET are widely used for detection of recurrent prostate cancer (PC). We present the first results of a comparative, prospective PET/CT study of both tracers evaluated in the same patients presenting with recurrence and low PSA to compare the diagnostic information provided by the two tracers.Methods
The study group comprised 23 patients studied for a rising PSA level after radical prostatectomy (RP, 7 patients, PSA ≤3 ng/ml), curative radiotherapy (RT, 7 patients, PSA ≤5 ng/ml) or RP and salvage RT (9 patients, PSA ≤5 ng/ml). Both FCH and ACE PET/CT scans were performed in a random sequence a median of 4 days (range 0 to 11 days) apart. FCH PET/CT was started at injection (307?±?16 MBq) with a 10-min dynamic acquisition of the prostate bed, followed by a whole-body PET scan and late (45 min) imaging of the pelvis. ACE PET/CT was performed as a double whole-body PET scan starting 5 and 22 min after injection (994?±?72 MBq), and a late view (45 min) of the prostate bed. PET/CT scans were blindly reviewed by two independent pairs of two experienced nuclear medicine physicians, discordant subgroup results being discussed to reach a consensus for positive, negative end equivocal results.Results
PET results were concordant in 88 out of 92 local, regional and distant findings (Cohen’s kappa 0.929). In particular, results were concordant in all patients concerning local status, bone metastases and distant findings. Lymph-node results were concordant in 19 patients and different in 4 patients. On a per-patient basis results were concordant in 22 of 23 patients (14 positive, 5 negative and 3 equivocal). In only one patient was ACE PET/CT positive for nodal metastases while FCH PET/CT was overall negative; interestingly, the ACE-positive and FCH-negative lymph nodes became positive in a second FCH PET/CT scan performed a few months later.Conclusion
Overall, ACE and FCH PET/CT showed excellent concordance, on both a per-lesion and a per-patient basis, suggesting that both tracers perform equally for recurrent prostate cancer staging. 相似文献159.
严重烧伤患者外周血T淋巴细胞亚群、NK细胞活性及sIL-2R水平的变化 总被引:1,自引:0,他引:1
目的观察严重烧伤患者伤后T淋巴细胞亚群、NK细胞活性和sIL2R水平的变化,探讨其免疫功能改变的可能机制。方法测定35例严重烧伤患者伤后T淋巴细胞亚群,NK细胞活性和sIL2R的水平,并与正常对照组进行比较。结果与正常对照组比较,烧伤组:CD3+、CD4+和CD4+/CD8+比值均明显下降(P均<0.01),CD8+明显升高(P<0.05),烧伤组NK细胞活性明显下降(P<0.05),sIL-2R明显升高(P<0.01)。结论严重烧伤患者T淋巴细胞亚群中细胞比例发生了明显改变,NK细胞活性降低sIL-2R水平升高,三者互相影响,共同构成烧伤患者伤后免疫功能紊乱的因素之一。 相似文献
160.
A M Fink N Herzog B Borst-Krafek W Jurecka A Steiner 《European journal of vascular and endovascular surgery》2006,31(2):200-203
OBJECTIVES: To assess the long-term mortality in patients with thrombosis of the vena cava, iliac and femoral veins. DESIGN: Registry study. MATERIALS: Between 1992 and 2000, 212 consecutive patients with acute pelvic vein thrombosis diagnosed by duplex sonography were examined by magnetic resonance imaging (MRI) to determine the most proximal extent of the thrombus. MRI revealed a thrombosis in the inferior vena cava in 46 patients (22%), in the iliac vein in 142 patients (67%), and in the femoral vein in 24 patients (11%). METHODS: The vital status of the patients was investigated in April 2004 using the Austrian National Registry and the Cause of Death Register. RESULTS: A total of 211 patients of the original 212 patients were monitored over a mean follow-up period of 91 months. Seventy-two of 211 patients (34%) had died. There was no significant difference in the long-term mortality, the survival period or the occurrence of fatal pulmonary embolism (PE) between previously diagnosed vena cava, iliac vein, or femoral vein thrombosis. CONCLUSIONS: Extension of a thrombus into the inferior caval vein in patients considered to have a pelvic vein thrombosis has no impact on long-term mortality or the development of fatal PE compared to those patients with thrombus limited to more distal veins. 相似文献