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941.
Michael D. Slater Kathleen J. Kelly Frank R. Lawrence Linda R. Stanley Maria Leonora G. Comello 《Prevention science》2011,12(1):12-22
Two media-based interventions designed to reduce adolescent marijuana use ran concurrently from 2005 to 2009. Both interventions used similar message strategies, emphasizing marijuana’s inconsistency with personal aspirations and autonomy. “Be Under Your Own Influence” was a randomized community and school trial replicating and extending a successful earlier intervention of the same name (Slater et al. Health Education Research 21:157–167, 2006). “Above the Influence” is a continuing national television, radio, and print campaign sponsored by the Office of National Drug Control Policy (ONDCP). This study assessed the simultaneous impact of the interventions in the 20 U.S. communities. Results indicate that earlier effects of the “Be Under Your Own Influence” intervention replicated only in part and that the most plausible explanation of the weaker effects is high exposure to the similar but more extensive ONDCP “Above the Influence” national campaign. Self-reported exposure to the ONDCP campaign predicted reduced marijuana use, and analyses partially support indirect effects of the two campaigns via aspirations and autonomy. 相似文献
942.
Stanley CJ Ellis DH Bates DL Johannsson A 《Journal of pharmaceutical and biomedical analysis》1987,5(8):811-820
The sensitivity of enzyme immunoassays may be enhanced by the use of enzyme-amplification. This technique uses the enzyme label in the immunoassay to provide a trigger substance for a secondary system that can generate a large quantity of coloured product. Two examples of enzyme amplifiers are described, using either a substrate cycle with phosphorylated hexose sugars, or a redox cycle involving the coenzyme NAD+. The redox enzyme-amplifier has a detection limit of less than one attomole for the enzyme label, alkaline phosphatase.
The limited dynamic range of enzyme-amplified immunoassays may be overcome by kinetic analysis of the colour development in the enzyme-amplifier, to add at least a further order of magnitude to the range of directly measured analyte concentrations in the immunoassay. This is illustrated in an enzyme-amplified immunoassay for human thyroid stimulating hormone. Amperometric measurement of the enzyme-amplifier provides a method to extend the dynamic range still further and compares favourably with the performance of a gamma counter, a luminometer or a fluorimeter. 相似文献
943.
Desmond H Foley Richard C Wilkerson Ian Birney Stanley Harrison Jamie Christensen Leopoldo M Rueda 《International journal of health geographics》2010,9(1):11
Background
Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. 相似文献944.
F 16915 prevents heart failure-induced atrial fibrillation: a promising new drug as upstream therapy
Bruno Le Grand Robert Letienne Elisabeth Dupont-Passelaigue Frédérique Lantoine-Adam Frédéric Longo Monique David-Dufilho Georghia Michael Kunihiro Nishida Daniel Catheline Philippe Legrand Stéphane Hatem Stanley Nattel 《Naunyn-Schmiedeberg's archives of pharmacology》2014,387(7):667-677
Atrial fibrillation (AF) is a common complication of heart failure. The aim of the present study was to investigate the effects of a new pure docosahexaenoic acid derivative called F 16915 in experimental models of heart failure-induced atria dysfunction. The atrial dysfunction-induced AF was investigated (1) in a dog model of tachypacing-induced congestive heart failure and (2) in a rat model of heart failure induced by occlusion of left descending coronary artery and 2 months reperfusion. F 16915 (5 g/day for 4 weeks) significantly reduced the mean duration of AF induced by burst pacing in the dog model (989?±?111 s in the vehicle group to 79?±?59 s with F 16915, P?<?0.01). This dose of F 16915 also significantly reduced the incidence of sustained AF (5/5 dogs in the vehicle group versus 1/5 with F 16915, P?<?0.05). In the rat model, the percentage of shortening fraction in the F 16915 group (100 mg/kg p.o. daily) was significantly restored after 2 months (32.6?±?7.4 %, n?=?9 vs 17.6?±?3.4 %, n?=?9 in the vehicle group, P?<?0.01). F 16915 also reduced the de-phosphorylation of connexin43 from atria tissue. The present results show that treatment with F 16915 reduced the heart dilation, resynchronized the gap junction activity, and reduced the AF duration in models of heart failure. Thus, F 16915 constitutes a promising new drug as upstream therapy for the treatment of AF in patients with heart failure. 相似文献
945.
Charlene Compher PhD RD CNSC LDN FASPEN Stanley J. Dudrick MD John R. Wesley MD FACS FAAP FASPEN Ainsley Malone MS RD LD CNSC FAND FASPEN Gordon S. Sacks PharmD BCNSP FCCP M. Molly McMahon MD Marion F. Winkler PhD RD LDN CNSC FASPEN Kris M. Mogensen MS RD LDN CNSC Arlet Kurkchubasche MD Meghan A. Arnold MD Hua Yang MD PhD Allison B. Blackmer PharmD BCPS Carol Braunschweig PhD RD Theresa Han‐Markey MS RD M. Luisa Partipilo PharmD BCNSP Mary Beth Harris MPH RD CSP CNSC Deb Kovacevich MPH BSN RN Bonnie Peters RN Alexis Cantwell Mary Ann Fithian 《JPEN. Journal of parenteral and enteral nutrition》2016,40(8):1079-1086
946.
Meningococcal conjugate vaccine safety surveillance in the Vaccine Safety Datalink using a tree‐temporal scan data mining method 下载免费PDF全文
947.
Marlise Richter Matthew F. Chersich Jo Vearey Benn Sartorius Marleen Temmerman Stanley Luchters 《Journal of immigrant and minority health / Center for Minority Public Health》2014,16(1):7-17
Intersections between migration and sex work are underexplored in southern Africa, a region with high internal and cross-border population mobility, and HIV prevalence. Sex work often constitutes an important livelihood activity for migrant women. In 2010, sex workers trained as interviewers conducted cross-sectional surveys with 1,653 female sex workers in Johannesburg (Hillbrow and Sandton), Rustenburg and Cape Town. Most (85.3 %) sex workers were migrants (1396/1636): 39.0 % (638/1636) internal and 46.3 % (758/1636) cross-border. Cross-border migrants had higher education levels, predominately worked part-time, mainly at indoor venues, and earned more per client than other groups. They, however, had 41 % lower health service contact (adjusted odds ratio = 0.59; 95 % confidence interval = 0.40–0.86) and less frequent condom use than non-migrants. Police interaction was similar. Cross-border migrants appear more tenacious in certain aspects of sex work, but require increased health service contact. Migrant-sensitive, sex work-specific health care and health education are needed. 相似文献
948.
Brunette MF Mercer CC Carlson CL Rosenberg SD Lewis BF 《The journal of behavioral health services & research》2000,27(3):347-353
Rates of HIV and HIV risk behaviors are elevated among people with severe mental illnesses (SMI). Little is known about the extent to which community mental health (CMH) centers screen, refer, and educate their clients regarding HIV and sexually transmitted diseases (STDs). The authors surveyed CMH administrators and clinicians in New Hampshire regarding HIV/STD policy, practices, knowledge, and attitudes. HIV/STD service availability varied, and the amount of services provided was unrelated to the prevalence of HIV and AIDS in that region. Clinicians were knowledgeable about general HIV information but lacked specific knowledge about HIV related to persons with SMI. CMH staff had positive attitudes about helping clients with HIV issues. Administrators were interested in receiving training. Policy leadership, CMH practice guidelines, and training are warranted in light of the pressing public health implications of HIV/STDs among people with SMI. 相似文献
949.
950.
Cara L. Booker Jennifer B. Unger Stanley P. Azen Lourdes Baezconde-Garbanati Brian Lickel C. Anderson Johnson 《Substance use & misuse》2013,48(11):1521-1543
Many studies have addressed the associations between stressful life events and adolescent smoking. Few studies, however, have examined gender differences, specifically with multicultural samples. This longitudinal study examines the relationship between 6 stress subscales and smoking behaviors 716 multicultural U.S. adolescents living in the greater Los Angeles area in 2000–2001. At baseline the ethnic break-down of the sample was 63% Latino and 26% Asian/PI and 70% were 11 years of age. Negative personal events were associated with lifetime smoking and negative school events were associated with intentions to smoke. Stratification of the sample by gender indicated that gender confounded the relationship between negative personal stress and lifetime smoking and negative school stress, positive personal stress and intentions to smoke. Two significant interactions were found. Findings indicate there are differential effects of stressful events between genders which may lead to smoking experimentation or intentions to smoke. Implications and limitations are discussed. 相似文献