Unusual radiographic presentation of an aneurysmal bone cyst of the mandible

An 11-year-old girl was referred because of a painless firm swelling in the right posterior mandible that had started 2 months previously. A panoramic radiograph showed a nonspecific finding of a tiny discreet shadow following the lower border of the mandible, without any radiographic signs of radiolucency in the affected area or discontinuity of the lower border. However, multislice computed tomography (MSCT) findings were suggestive of an aneurysmal bone cyst, and histopathological findings revealed a diagnosis of aneurysmal bone cyst. Complete surgical excision followed by extensive cortical bone curettage was done, and no recurrence has been observed in the past 5 years. A differential diagnosis list is included, and extended with fibrous dysplasia according to the radiographic findings. To the best of our knowledge, this is the first case of a jaw aneurysmal bone cyst with unusual initial radiographic findings. Furthermore, a ground-glass appearance on MSCT scans suggested fibrous dysplasia. The present case highlights the need for accurate differential diagnosis of the lesion described to obtain the correct diagnosis in a timely manner and plan the appropriate treatment.     

Solid lipid microparticles containing loratadine prepared using a Micromixer

Solid lipid microparticles were investigated as a taste-masking approach for a lipophilic weak base in a suspension. The idea was that the drug concentration in the aqueous phase of a suspension might be reduced by its partitioning into the solid lipid particles. Loratadine, as a model drug, was used to prepare Precirol ATO 5 microparticles by a Micromixer. The effects of three process variables: drug loading, PVA concentration and water/lipid ratio on the microparticle size, encapsulation efficiency, surface appearance, in-vitro release and drug partitioning in a suspension were studied. Loratadine release was slow in simulated saliva and very fast at the pH of stomach. In suspension of loratadine lipid microparticles, drug was released into the aqueous phase to the same concentration as in a drug suspension. Therefore, the usefulness of these microparticles for taste-masking in liquids is limited. However, they might be useful for taste-masking in solid dosage forms.     

Characterization and behavior of anesthetic bioactive textile complex in vitro condition

In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 μm. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.     

Pleomorphic rhabdomyosarcoma of the larynx--a case report and literature review

Rhabdomyosarcoma is a very rare malignant tumor of the larynx which can present in a number of histologic variants. The pleomorphic variant of the tumor has been described in 16 patients to date. Being a rarity, rhabdomyosarcoma is as a rule managed according to the principle of treatment for malignant mesenchymal tumors of the head and neck, and includes radical surgery with postoperative radiotherapy and/or chemotherapy. A case is presented of a pleomorphic rhabdomyosarcoma of the vocal cord. Successfully treated by endoscopic CO2 laser cordectomy with adjuvant chemotherapy and 6-year uneventful follow up.     

Direct stimulation of lymphoid tissue of the chicken. 3. Haemagglutinin production, haemolysin-forming cells and changes in lymphoid tissues following injection of guinea-pig erythrocytes into the bone marrow

The hypothesis that the avian bone marrow is a site of actual antibody production has been experimentally verified in this study. Normal and neonatally bursectomized 8-week-old White Rock chickens were injected with guinea-pig red blood cells into the left femoral marrow or into the wing vein. The intramarrow administration of antigen proved to be as effective as the intravenous injection in inducing the production of haemagglutinins and antibody plaque response of 19S class. An important finding was that White Rock bursaless chickens were capable of synthesizing considerable amount of circulating 19S agglutinin after a single challenge with guinea-pig erythrocytes. There was a significant proliferation of plaque-forming cells in the spleen and bone marrow of normal immunized chickens.Quantitative cytological analysis revealed that an increase in the number of small and immature lymphocytes preceded the appearance of cells of the plasmacytic series in both antigen-injected marrow and contralateral non-injected marrow. The thymus and bursa did not exhibit apparent changes. This study provides strong evidence that chicken bone marrow may act in antibody production as a secondary lymphatic tissue. The results are discussed with respect to the interaction between thymus-derived, bursa-derived and bone marrow-derived cells in humoral immunity of the chicken.     

Acquired Blaschko Dermatitis-seventh case

The February edition of Dermatology Online Journal 2002;7(1):8, contained an article entitled Acquired Blaschko Dermatitis.[1] A 64 year old patient with erythematous patches and papules in a reticulate pattern on the left upper extremity and on the left side of the chest, abdomen, back and buttock was described. Three months later, in the Department of Dermatology, Health Center Krusevac, we examined a 65 year old woman with similar lesions, distributed in a linear pattern on her right lower limb, following the lines of Blaschko.     

Sclerosing polycystic adenosis of parotid gland: A unique report of two cases occurring in two sisters

Sclerosing polycystic adenosis (SPA) of salivary glands is a tumorous lesion of salivary glands, with clinical presentation of a slow-growing mass characterized by a combination of histological features, some of which are reminiscent of mammary fibrocystic disease. SPA is mostly unifocal, but rarely may be multifocal and/or bilateral. Recurrences have been reported in up to 19% of cases. Although originally considered pseudoneoplastic, the occurrence of “dysplasia” and carcinoma in situ of ductal epithelium, and recent evidence of clonality suggest a possible neoplastic nature. Herein we describe, for the first time, two cases of SPA in two sisters (7 and 33 years old). The younger patient experienced multiple recurrences. This is the first report of familial occurrence of SPA, suggesting a possible genetic background.     

Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury

Background  

Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy for the management of ischemic brain injury. Decay-accelerating factor (DAF, also known as CD55) inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. The present study investigates the ability of DAF to protect primary cultured neuronal cells subjected to sodium cyanide (NaCN)-induced hypoxia from degeneration and apoptosis.