Six-month follow-up of children with obstructive sleep apnoea

OBJECTIVES: This study examined prospectively changes in development, temperament and sleep related behaviour in children referred for obstructive sleep apnoea (OSA) and polysomnographic sleep study, some of whom had surgical intervention. METHODOLOGY: Using a prospective cohort study design, parents of 56 children referred for OSA completed sleep and temperament questionnaires and their child was assessed developmentally at the time of the polysomnographic sleep study. Forty (72%) of the children were neurologically normal. At 6 months, 42 children were reassessed using sleep and temperament questionnaires and a developmental assessment. After excluding the primary snorers, subjects were categorised as having had intervention (n = 24) or not (n = 15), and differences over the 6-month period in Griffiths scores, temperament and sleep related behaviour were examined. RESULTS: Regardless of intervention status, there was an improvement in night-time and day-time sleep behaviour for the total group, though the extent of improvement was more marked in the intervention group. For the neurologically normal children, improvement in the sleep behaviour was only significant for the intervention group (P < 0.05). Intervention did not result in any significant changes in Griffiths developmental score or temperament. CONCLUSION: Surgical intervention improves sleep behaviour in children though not temperament or development.     

Effect of vitamin E on chromosomal aberrations in lymphocytes from patients with Down's syndrome

A possible protective effect of vitamin E (DL-alpha-tocopherol) on chromosomal damage was evaluated in lymphocytes from patients with Down's syndrome (DS) and from controls. This included the analysis of the basal and G2 chromosomal aberration frequencies in lymphocytes cultured with and without 100 microM vitamin E. The chromosomal damage in G2 was determined by scoring the number of chromosomal aberrations in lymphocyte cultures treated with 5 mM caffeine, 2 h before harvesting. Vitamin E treatment decreased the basal and G2 chromosomal aberrations both in control and DS lymphocytes. In DS cells, this protective effect, expressed as a decrease in the chromosomal damage, was greater (50%) than in controls (30%). These results suggest that the increment in basal and G2 aberrations yield in DS lymphocytes may be related to the increase in oxidative damage reported in these patients.     

Claeys MJ,Bosmans JM,Hendrix J,Vrints CJ. Reliability of fractional flow reserve measurements in patients with associated microvascular dysfunction: Importance of flow on translesional pressure gradient. Cathet Cardiovasc Intervent 2001;54:427–434

The original article to which this Erratum refers was published in Catheterization and Cardiovascular Interventions; 2002; 54(4) 427–434     

广西藤茶中黄酮类成份的提取工艺研究

目的：提取分离藤（Ａｍｐｅｌｏｓｉｓ ｇｒｏｓｓｄｅｎｔａｔａ）中的双氢杨梅树皮素（ｄｉｈｙｄｒｏｍｙｒｉｃｅｔｉｎ）和杨梅素（Ｍｙｒｉｃｅｔｉｎ）。方法：采用新的水提取和溶剂分离的方法,经化学和光谱鉴定确定结构。结果：提取产物经确证为双氢杨梅树皮素（ｄｉｈｙｄｒｏｍｙｒｉｃｅｔｉｎ）和杨梅素（Ｍｙｒｉｃｅｔｉｎ）,平均收率分别为１９．６％和０．５１％。结论：该提取法经济、简便,易于操作并且提取率