全文获取类型
收费全文 | 4180篇 |
免费 | 283篇 |
国内免费 | 93篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 106篇 |
妇产科学 | 43篇 |
基础医学 | 686篇 |
口腔科学 | 55篇 |
临床医学 | 458篇 |
内科学 | 706篇 |
皮肤病学 | 172篇 |
神经病学 | 251篇 |
特种医学 | 466篇 |
外科学 | 208篇 |
综合类 | 67篇 |
预防医学 | 188篇 |
眼科学 | 101篇 |
药学 | 525篇 |
中国医学 | 104篇 |
肿瘤学 | 397篇 |
出版年
2023年 | 13篇 |
2022年 | 77篇 |
2021年 | 83篇 |
2020年 | 49篇 |
2019年 | 76篇 |
2018年 | 103篇 |
2017年 | 85篇 |
2016年 | 149篇 |
2015年 | 169篇 |
2014年 | 222篇 |
2013年 | 261篇 |
2012年 | 329篇 |
2011年 | 326篇 |
2010年 | 274篇 |
2009年 | 202篇 |
2008年 | 214篇 |
2007年 | 270篇 |
2006年 | 211篇 |
2005年 | 204篇 |
2004年 | 167篇 |
2003年 | 132篇 |
2002年 | 118篇 |
2001年 | 37篇 |
2000年 | 20篇 |
1999年 | 35篇 |
1998年 | 69篇 |
1997年 | 74篇 |
1996年 | 62篇 |
1995年 | 62篇 |
1994年 | 40篇 |
1993年 | 49篇 |
1992年 | 20篇 |
1991年 | 22篇 |
1990年 | 24篇 |
1989年 | 50篇 |
1988年 | 39篇 |
1987年 | 38篇 |
1986年 | 20篇 |
1985年 | 23篇 |
1984年 | 13篇 |
1983年 | 8篇 |
1982年 | 20篇 |
1981年 | 20篇 |
1980年 | 20篇 |
1979年 | 11篇 |
1978年 | 5篇 |
1977年 | 14篇 |
1976年 | 11篇 |
1975年 | 7篇 |
1971年 | 4篇 |
排序方式: 共有4556条查询结果,搜索用时 0 毫秒
71.
Hyun Jeong Park Seong Sook Hong Jiyoung Hwang Kyung Yul Hur 《Korean journal of radiology》2015,16(2):325-333
Laparoscopic mini-gastric bypass surgery is a safe and simple surgical intervention for treating morbid obesity and diabetes mellitus and is now being performed more frequently. Radiologists must be critical in their postoperative evaluation of these patients. In this pictorial review, we explain and illustrate the surgical technique, normal postoperative anatomy, and associated complications as seen on imaging examinations, including fluoroscopy and computed tomography. 相似文献
72.
73.
Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V 总被引:6,自引:1,他引:6
Gln506-factor V (FV) was purified from plasma of an individual homozygous for an Arg506Gln mutation in FV that is associated with activated protein C (APC) resistance. Purified Gln506-FV, as well as Gln506-FVa generated by either thrombin or FXa, conveyed APC resistance to FV-deficient plasma in coagulation assays. Clotting assay studies also suggested that APC resistance does not involve any abnormality in FV-APC-cofactor activity. In purified reaction mixtures, Gln506-FVa in comparison to normal FVa showed reduced susceptibility to APC, because it was inactivated approximately 10-fold slower than normal Arg506-FVa. It was previously reported that inactivation of normal FVa by APC involves an initial cleavage at Arg506 followed by phospholipid- dependent cleavage at Arg306. Immunoblot and amino acid sequence analyses showed that the 102-kD heavy chain of Gln506-FVa was cleaved at Arg306 during inactivation by APC in a phospholipid-dependent reaction. This reduced but measurable susceptibility of Gln506-FVa to APC inactivation may help explain why APC resistance is a mild risk factor for thrombosis because APC can inactivate both normal FVa and variant Gln506-FVa. In summary, this study shows that purified Gln506- FV can account for APC resistance of plasma because Gln506-FVa, whether generated by thrombin or FXa, is relatively resistant to APC. 相似文献
74.
75.
Jae Kyun Choi Soomin Ahn Jai Young Cho YoungRok Choi Ho‐Seong Han Boo‐ok Jang Gwang Hyeon Choi Eun Sun Jang Jin‐Wook Kim Sook‐Hyang Jeong 《Transplant infectious disease》2020,22(3)
Acute hepatitis E virus (HEV) infection could lead to acute liver failure (ALF), which requires liver transplantation (LT). HEV infection could progress to chronic infection in an immunosuppressed host. De novo autoimmune hepatitis (AIH) is a rare occurrence of AIH during post‐LT immunosuppressive therapy in patients who underwent LT due to not AIH but some other etiology. Here, we report the first case of ALF due to HEV infection, the recurrence of HEV after LT that responded to ribavirin therapy, and then the development of de novo AIH showing a complete response to glucocorticoid therapy but multiple relapses after steroid withdrawal. This peculiar case suggests that HEV could have a pathogenic role in the development of the de novo AIH; additionally, this case report could help clinicians make therapeutic decisions in the post‐LT condition. 相似文献
76.
77.
Chan Ho Kim Hyung Jung Oh Mi Jung Lee Young Eun Kwon Yung Ly Kim Ki Heon Nam Kyoung Sook Park Seong Yeong An Kwang Il Ko Hyang Mo Koo Fa Mee Doh Seung Hyeok Han Tae-Hyun Yoo Beom Seok Kim Shin-Wook Kang Kyu Hun Choi 《Yonsei medical journal》2014,55(1):141-148
Purpose
The effect of different peritoneal dialysis (PD) modalities on the decline in residual renal function (RRF) is unclear due to inconsistencies among studies. In particular, the effect of automated peritoneal dialysis (APD) modalities [continuous cyclic peritoneal dialysis (CCPD) and nightly intermittent peritoneal dialysis (NIPD)] on RRF has not been examined in a large cohort.Materials and Methods
We conducted a single-center retrospective study to investigate the association between PD modalities and decline in RRF in 142 incident PD patients [34 on CCPD, 36 on NIPD, and 72 on continuous ambulatory peritoneal dialysis (CAPD)]. RRF was measured within 2 months from PD start and at 1 year after PD initiation.Results
The RRF at 1 year after PD initiation was 1.98±2.20 mL/min/1.73 m2 in CCPD patients and 3.63±3.67 mL/min/1.73 m2 in NIPD patients, which were moderately lower than 4.23±3.51 mL/min/1.73 m2 in CAPD patients (p=0.064). Moreover, there was no significant difference in the 1-year rate of decline of RRF between CCPD and NIPD patients, although APD patients had a faster 1-year RRF decline rate than CAPD patients (CCPD and NIPD vs. CAPD: -45.68 and -36.69 vs. 1.17%/year, p=0.045). APD was associated with a more rapid decline in RRF in patients with end-stage renal disease undergoing PD, although multivariate analysis attenuated the significance of this finding (β=-31.50; 95% CI, -63.61 to 0.62; p=0.052).Conclusion
Our results suggest that CAPD might be more helpful than APD for preserving RRF during the first year of dialysis therapy, although there was no significant difference in the 1-year rate of decline of RRF between the two APD modalities. 相似文献78.
Hea Yon Lee Ji Young Kang Hyoung Kyu Yoon Sook Young Lee Soon Suk Kwon Young Kyoon Kim Chin Kook Rhee 《Yonsei medical journal》2014,55(4):980-986
Purpose
In clinical practice, some patients with asthma show incompletely reversible airflow obstruction, resembling chronic obstructive pulmonary disease (COPD). The aim of this study was to analyze this overlap phenotype of asthma with COPD feature.Materials and Methods
A total of 256 patients, over the age of 40 years or more with a diagnosis of asthma, based on either 1) positive response to bronchodilator: >200 mL forced expiratory volume in 1 s (FEV1) and >12% baseline or 2) positive methacholine or mannitol provocation test, were enrolled. Among the asthma patients, we defined the overlap group with incompletely reversible airflow obstruction [postbronchodilator FEV1/forced vital capacity (FVC) <70] at the initial time of admission and continuing airflow obstruction after at least 3 months follow up. We evaluated clinical features, serum eosinophil counts, serum total immunoglobulin (Ig) E with allergy skin prick test, spirometry, methacholine or mannitol provocation challenges and bronchodilator responses, based on their retrospective medical record data. All of the tests mentioned above were performed within one week.Results
The study population was divided into two groups: asthma only (62%, n=159, postbronchodilator FEV1/FVC ≥70) and overlap group (38%, n=97, postbronchodilator FEV1/FVC <70). The overlap group was older, and contained more males and a higher percentage of current or ex-smokers than the asthma only group. Significantly lower FEV1 and higher total lung capacity, functional residual capacity, and residual volume were observed in the overlap group. Finally, significantly lower serum eosinophil count and higher IgE were seen in the overlap group.Conclusion
Our results showed that the overlap phenotype was older, male asthmatic patients who have a higher lifetime smoking intensity, more atopy and generally worse lung function. 相似文献79.
Ji Yeon Kang Sook Hee Sung Yeon Ju Lee Tae In Choi Seung Jin Choi 《Journal of Korean medical science》2014,29(10):1353-1359
Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG]; and 302 intervention group [IG]) and 77 in subjects with Q allele (KQ+QQ) (13 CG and 64 IG). The web-based intervention based on a lifestyle modification was delivered by e-mail once a month for 10 months. In the KK, IG demonstrated significantly decreased levels of fasting serum insulin (FSI) as compared to CG and homeostasis model of assessment of insulin resistance (HOMA-IR). In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG. After analysis of covariance, K121Q did significantly influence the change of HbA1c in CG after appropriate adjustment. In a multivariate model, BMI change predicted HOMA-IR change (adjusted β=0.801; P=0.022) in KK IG subjects with T2DM. ENPP1 K121Q did not influence the change in IR. However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.
Graphical Abstract
相似文献80.
Byeong-Ho Jeong Gee Young Suh Jin Young An Moo Suk Park Jin Hwa Lee Myung-Goo Lee Je Hyeong Kim Yun Seong Kim Hye Sook Choi Kyung Chan Kim Won-Yeon Lee Younsuck Koh 《Journal of Korean medical science》2014,29(6):864-870
Knowledge of clinical demographics and outcomes of mechanically ventilated patients is important but there are few prospectively collected data in Korea. The objective of the present study was to describe the current status of mechanically ventilated patients in Korea as of 2010. We analyzed the data of Korean patients (275 patients in 12 Korean intensive care units [ICU]) participating in a multinational prospective cohort study on mechanical ventilation. The most common indication for mechanical ventilation was pneumonia (23%). Pressure-limited ventilation modes were preferred over volume-cycled ventilation modes. Non-invasive positive pressure ventilation was used in only seven (2%) patients as the initial ventilatory support. Median duration of mechanical ventilation was 7 days and ICU mortality was 36%. The multiple logistic regression model revealed that the Simplified Acute Physiology Score II (SAPS II) score at ICU admission (odds ratio [OR], 1.034; 95% confidence interval [CI], 1.001-1.036; P=0.033), peak pressure (OR, 1.054; 95% CI, 1.016-1.095; P=0.006), and the number of failed organs (OR, 2.132; 95% CI, 1.634-2.781; P<0.001) were independently associated with ICU mortality. This study provides a snapshot of current practice of mechanical ventilation in Korea.