MODIFIED BROMOPHENOL BLUE DYE BINDING METHOD FOR QUANTITATION OF MICROALBUMINURIA IN DIABETES MELLITUS

Albumin excretion in microalbuminuria range is one of the earliest manifestation of nephropathy, specially in diabetes mellitus. The modified dye binding method using bromo-phenol blue was studied in 27 healthy controls and 54 patients of diabetes mellitus, negative for albuminuria by albustix test. The analytical recovery (99.4 to 104.0%), within run coefficient of variation (0.8 to 0.36%) and day-to-day coefficient of variation (2.39 to 0.82%), for low and higher range were within acceptable limits. The values in controls ranged as follows: urinary albumin concentration (mg/L) 7.7 – 28.4 in 2-hour specimen and 10.3 – 29.2 in overnight specimen; albumin excretion rate (µg/min) 7.8 – 29.7 in 2-hour and 9.2 – 29.6 in overnight specimen; and albumin creatinine ratio (mg/g) 10.6 – 29.6 in 2-hour and 11.9 – 29.6 in overnight specimens.Correlation analysis of various albumin excretion parameters revealed excellent correlation between estimations from overnight and 2-hour samples for albumin-creatinine ratio (r = 1.00) and albumin excretion rate (r=0.96). Equally good correlation was observed between 2-hour albumin-creatinine ratio and albumin excretion rate (r=0.95). In 10 of 54 patients excretion rate was more than 200 µg/min and could have been detected by repeat albustix test. Of the 36 positive for microalbuminuria, 21 had one or more target organ involvement. There was no target organ involvement in 8 patients negative for microalbuminuria. Screening for microalbuminuria by this simple and economic method, using 2-hour albumin-excretion rate or albumin-creatinine ratio could be one of the earliest investigations in diabetic patients.KEY WORDS: Microalbuminuria, Spectrophotometeric method, Diabetes mellitus     

LIPID PROFILE IN NORMAL HEALTHY CHILDREN

One hundred and fifty healthy children in the age group of 0–12 years were studied to establish normal levels of lipid profile. They were divided into six equal groups viz., newborns, 0–1 year, 1–4 years, 4–7 years, 7–10 years and 10–12 years. The mean values ± SD for total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides were 70 ± 14.48 mg/dl, 35.1 ± 8.04 mg/dl, 23.8 ± 10.62 mg/dl and 50.9 ± 20.77 mg/dl respectively for male neonates and 71.8 ± 13.96 mg/dl, 34.6 ± 6.55 mg/dl, 25.5 ± 9.29 mg/dl and 57.2 ± 18.57 mg/dl respectively for female neonates. These values increased to 158.7 ± 21.23 mg/dl, 60.7 ± 11.70 mg/dl, 80.3 ± 19.26 mg/dl, 86.7 ± 28.80 mg/dl in males and 161.6 ± 23.09 mg/dl 66.7 ± 8.75 mg/dl, 75.8 ± 20.26 mg/dl and 93.2 ± 44.09 mg/dl in females respectively between 10–12 years of age, The various lipid fractions were at the lowest level at birth and increased significantly during first year of life, there after showing a much slower rise in levels. There was no significant difference in values between male and female children.KEY WORDS: Lipid profile, Total cholesterol, HDL cholesterol, LDL cholesterol, Triglycerides     

医院大规模收治SARS病人时的护理人力资源管理

大规模收治SARS病人时医院护理部采取及时计划部署，灵活调整补充人力；发挥护理骨干的作用；制定在非常时期的管理规定；重视人性关怀等措施，有效地提高护理团队的战斗力。提出护理管理者在人才培养，人力的配置和使用方面需要深入的探讨和研究。     

行为主义理论在小儿脑瘫功能训练中的应用

目的探讨桑代克的行为主义理论在脑瘫患儿运动功能训练中的作用。方法将80例脑瘫患儿按时间先后顺序分为两组,一对一训练组36例采用一对一的训练,综合训练组44例采用综合训练,以改善主、客观因素对脑瘫患儿训练活动中的不利影响。结果通过采用上述两种不同的治疗方式对患儿进行运动功能训练,一对一训练组36例患儿疗效显著19例,有效11例,无效6例;综合训练组疗效显著31例,有效11例,无效2例。采用Ridit分析u=34.333,P<0.01,差异有统计学意义。结论行为主义理论指导下进一步深化的综合训练法是以患儿为中心的综合性治疗,疗效显著,值得临床推广应用。     

膀胱内注射肉毒素A治疗氯胺酮相关性膀胱功能障碍28例临床研究

目的 探讨肉毒素A膀胱内注射治疗氯胺酮相关性膀胱功能障碍的临床价值、疗效.方法 我院从2009年8月至2014年7月收治氯胺酮相关性膀胱功能障碍患者28例,膀胱镜下均匀分布于膀胱逼尿肌内注射A型肉毒素200U,记录治疗前及治疗1、4、12周后患者临床症状(日间排尿次数、夜间排尿次数、每次尿量、OABSS评分)改善情况,及利用抑郁焦虑自评表对比患者治疗前与治疗后4周评分,进行疗效评价.结果 患者治疗前及治疗后1、4、12周日间排尿次数分别为(21.39±3.60)、(15.94±3.29)、(14.83±2.67)、(13.33±2.33)次,夜间排尿次数分别为(14.28±3.91)、(9.72±3.20)、(7.83±2.00)、(7.28±1.84)次,治疗后排尿次数明显减少;每次尿量分别为(30.00±8.89)、(52.56±6.78)、(60.94±8.04)、(65.67±12.40) mL,治疗后排尿量增加;OABSS评分分别为(10.0±1.19)、(7.61±1.04)、(7.17±1.20)、(6.94±1.16)分,较治疗前明显下降,临床症状指标比较差异有统计学意义(P＜0.01).患者治疗前与治疗后4周抑郁与焦虑的心理评分分别为(48.44±5.87)、(38.39±4.77)与(51.39±4.33)、(38.78±5.24)分,差异具有统计学意义(P＜0.01).结论 戒除氯胺酮,肉毒素A膀胱内注射治疗可短期内较明显缓解氯胺酮相关性膀胱功能障碍症状,长期疗效仍需进一步随访.     

公共关系学与学科形象建设关系的研究

目的 研究公共关系学与学科形象建设的关系,提高学科在医疗市场的竞争能力 方法 正确运用激励机制,增强内部凝聚力;提高医疗护理水平,让公众信任自己;改变旧的服务观念,让公众了解自己;尊重服务对象,让公众宣传自己 结果 塑造了团队形象,“名牌”技术形象,“人性化”服务形象和和睦家庭形象。结论公共关系是学科管理者“内求团结,外求发展”的管理艺术。     

Reactive-inflammatory and degenerative-dystrophic changes in the nervous system in experimental syringomyelia

The results of immunomorphologic and histochemical investigations of 12 rabbits with experimental syringomyelia are presented. Chronic pachymeningitis of the hind brain, resulting from the administration of kaolin leads to the disorders of liquor circulation on the level of outlet of the fourth ventricle this being a start mechanism for the cavity formation in the spinal cord. The reactive inflammatory, degenerative and immune reactions accompany the formation of cavity in the nervous tissue. The formation of cavity is followed by asymmetrical segment demyelination and reparative hyperplasia of the astroglial cells and gliosis of the cavity walls.     

黄龙通络胶囊治疗中风病的临床研究

目的:观察黄龙通络胶囊治疗中风病的临床疗效.方法:采用随机对照试验,共观察病人120例,其中黄龙通络胶囊治疗组90例,中风回春片对照组30例,两组均治疗28天.结果:黄龙通络胶囊治疗组愈显率72.2%,总有效率93.33%;中风回春片对照组愈显率40%,总有效率83.33%,两组比较有统计学意义(P＜0.01).结论:黄龙通络胶囊具有化瘀通络、益气活血的功效,用于治疗中风病能明显改善患者的临床症状、体征,降低血浆比黏度、红细胞比容、纤维蛋白元、并能调节脂代谢紊乱,改善患者高血压状态,是治疗中风病人的有效药物.