全文获取类型
收费全文 | 490篇 |
免费 | 47篇 |
国内免费 | 8篇 |
专业分类
儿科学 | 13篇 |
妇产科学 | 13篇 |
基础医学 | 45篇 |
口腔科学 | 38篇 |
临床医学 | 50篇 |
内科学 | 153篇 |
皮肤病学 | 16篇 |
神经病学 | 32篇 |
特种医学 | 73篇 |
外科学 | 26篇 |
综合类 | 8篇 |
一般理论 | 1篇 |
预防医学 | 25篇 |
眼科学 | 4篇 |
药学 | 29篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 12篇 |
2018年 | 4篇 |
2017年 | 2篇 |
2016年 | 7篇 |
2015年 | 16篇 |
2014年 | 8篇 |
2013年 | 23篇 |
2012年 | 10篇 |
2011年 | 8篇 |
2010年 | 22篇 |
2009年 | 20篇 |
2008年 | 18篇 |
2007年 | 17篇 |
2006年 | 4篇 |
2005年 | 4篇 |
2004年 | 4篇 |
2003年 | 5篇 |
2002年 | 5篇 |
2001年 | 5篇 |
1999年 | 9篇 |
1998年 | 21篇 |
1997年 | 36篇 |
1996年 | 33篇 |
1995年 | 20篇 |
1994年 | 24篇 |
1993年 | 20篇 |
1992年 | 6篇 |
1991年 | 13篇 |
1990年 | 13篇 |
1989年 | 15篇 |
1988年 | 16篇 |
1987年 | 13篇 |
1986年 | 15篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 16篇 |
1982年 | 19篇 |
1981年 | 15篇 |
1980年 | 7篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有545条查询结果,搜索用时 15 毫秒
101.
Seah Davinia S. Tayob Nabihah Leone Jose Pablo Hu Jiani Yin Jun Hughes Melissa Scott Sarah M. Lederman Ruth I. Frank Elizabeth Sohl Jessica J. Stadler Zsofia K. Erick Timothy K. Peppercorn Jeffrey Winer Eric P. Silverman Stuart G. Come Steven E. Lin Nancy U. 《Breast cancer research and treatment》2022,192(1):201-210
Breast Cancer Research and Treatment - We sought to understand the attitudes of individuals with abnormal breast imaging findings prompting a diagnostic breast biopsy toward donation of blood,... 相似文献
102.
CJH Kramer L Lanjouw D Ruano A ter Elst G Santandrea N Solleveld-Westerink N Werner AH van der Hout CD de Kroon T van Wezel LPV Berger M Jalving J Wesseling VTHBM Smit GH de Bock CJ van Asperen MJE Mourits MPG Vreeswijk J Bart T Bosse 《The Journal of pathology》2024,262(2):137-146
The identification of causal BRCA1/2 pathogenic variants (PVs) in epithelial ovarian carcinoma (EOC) aids the selection of patients for genetic counselling and treatment decision-making. Current recommendations therefore stress sequencing of all EOCs, regardless of histotype. Although it is recognised that BRCA1/2 PVs cluster in high-grade serous ovarian carcinomas (HGSOC), this view is largely unsubstantiated by detailed analysis. Here, we aimed to analyse the results of BRCA1/2 tumour sequencing in a centrally revised, consecutive, prospective series including all EOC histotypes. Sequencing of n = 946 EOCs revealed BRCA1/2 PVs in 125 samples (13%), only eight of which were found in non-HGSOC histotypes. Specifically, BRCA1/2 PVs were identified in high-grade endometrioid (3/20; 15%), low-grade endometrioid (1/40; 2.5%), low-grade serous (3/67; 4.5%), and clear cell (1/64; 1.6%) EOCs. No PVs were identified in any mucinous ovarian carcinomas tested. By re-evaluation and using loss of heterozygosity and homologous recombination deficiency analyses, we then assessed: (1) whether the eight ‘anomalous’ cases were potentially histologically misclassified and (2) whether the identified variants were likely causal in carcinogenesis. The first ‘anomalous’ non-HGSOC with a BRCA1/2 PV proved to be a misdiagnosed HGSOC. Next, germline BRCA2 variants, found in two p53-abnormal high-grade endometrioid tumours, showed substantial evidence supporting causality. One additional, likely causal variant, found in a p53-wildtype low-grade serous ovarian carcinoma, was of somatic origin. The remaining cases showed retention of the BRCA1/2 wildtype allele, suggestive of non-causal secondary passenger variants. We conclude that likely causal BRCA1/2 variants are present in high-grade endometrioid tumours but are absent from the other EOC histotypes tested. Although the findings require validation, these results seem to justify a transition from universal to histotype-directed sequencing. Furthermore, in-depth functional analysis of tumours harbouring BRCA1/2 variants combined with detailed revision of cancer histotypes can serve as a model in other BRCA1/2-related cancers. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 相似文献
103.
Dr. S. Sohl R. Renner U. Winter M. Bodendorf U. Paasch J.C. Simon R. Treudler 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》2009,60(10):826-829
Patients treated with TNF-α inhibitors frequently have serum autoantibodies, but only a few develop clinically apparent lupus erythematosus. The TNF-α inhibitor adalimumab is a fully humanized antibody and seems to induce autoantibodies less frequently than other drugs of this group. We report on a patient with rheumatoid arthritis, who developed anti-histone antibodies and lupus tumidus after eight months on adalimumab therapy. 相似文献
104.
Anne Moyer Stephanie J. Sohl Sarah K. Knapp-Oliver Stefan Schneider 《Cancer treatment reviews》2009,35(5):475-484
The considerable amount of research examining psychosocial interventions for cancer patients makes it important to examine its scope and methodological quality. This comprehensive overview characterizes the field with as few exclusions as possible. A systematic search strategy identified 673 reports comprising 488 unique projects conducted over a 25 year time span. Although the literature on this topic has grown over time, the research was predominantly conducted in the United States (57.0%), largely with breast cancer patients (included in 70.5% of the studies). The intervention approach used most frequently was cognitive behavioral (32.4%), the treatment goal was often improving quality of life generally (69.5%), and the professionals delivering the interventions were typically nurses (29.1%) or psychologists (22.7%). Overall, there was some discrepancy between the types of interventions studied and the types of supportive services available to and sought by cancer patients. Strengths of this research include using randomized designs (62.9%), testing for baseline group equivalence (84.5%), and monitoring treatment, which rose significantly from being used in 48.1–64.4% of projects over time. However, deficiencies in such areas as examining treatment mechanisms and the adequacy of reporting of methodology, essential for useful syntheses of research on these interventions, remain to be addressed. Methodological challenges related to the complexity of this applied research, such as participants seeking treatment outside of research, contamination, and reactions to randomization, also were apparent. Future research could benefit from closer interactions between academic and voluntary sectors and expanding the diversity of participants. 相似文献
105.
106.
107.
108.
109.
Three children aged 17 months to 17 years developed right-sided peripheral lung abscesses. Clinical signs were fever and cough. Laboratory cultures were negative, and the patients did not respond to appropriate antibiotic coverage. Under fluoroscopic guidance, purulent material was removed from the abscesses by needle aspiration. The patients became afebrile within 24 hours; none suffered complications of bleeding or pneumothorax. Cultures of the aspirate were positive for microorganisms sensitive to the prescribed treatments. A simple aspiration technique is described and proposed as useful for selected patients when surgical drainage is recommended. There was no morbidity in our cases, and recovery from a typically prolonged course was shortened by the procedure. 相似文献
110.
功能性消化不良者胃排空功能和体表胃电变化的研究 总被引:1,自引:0,他引:1
以SPECT胃排空检测技术和WCDF-4B胃电分析仪检测了12例FD患者液、固体食物胃排空和体表胃电图的变化。结果显示:FD患者的液体胃排空与对照组无明显差异,仅在摄食后比对照组更多地分布于远端胃内:固体食物的排模式发生变化,表现为初始排空较快,继后的排空延缓,7例半排空时间延长。 相似文献