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991.
992.
A Kumar P K Misra R Mehotra Y C Govil G S Rana 《The American review of respiratory disease》1991,143(6):1350-1352
Serologic markers for hepatitis viruses were studied in 40 children who developed acute hepatitis during antituberculosis therapy with rifampin and isoniazid, with the aim of assessing the contributory role of these viruses toward producing hepatic injury. Hepatitis A and B were confirmed in 7.5 and 35% patients, respectively, by IgM antibodies. Epidemiologic evidence suggested the possibility of non-A, non-B hepatitis in at least a few of the remaining 23 children. Hepatitis B was seen more often in children with severe tubercular disease (72%) and was largely (92.8%) parenterally transmitted. The study highlights that the endemicity of viral hepatitis in developing countries, among other factors, could also be responsible for the reported higher incidence of hepatotoxicity from developing countries and also for the increased risk of hepatotoxicity seen in severe tubercular disease. 相似文献
993.
Kazrin is a recently described desmosomal protein that binds the cornified envelope precursor periplakin. In this study, we have examined kazrin isoform A expression during the development of Xenopus tropicalis and investigated the consequences of its depletion. Whole mount in situ hybridisation revealed that kazrinA mRNA is expressed throughout the embryo at least until tadpole stages. Xenopus tropicalis embryos that had been injected with antisense morpholino oligonucleotides directed against kazrinA failed to elongate properly and showed defects in development of the head, eye, notochord, and somites. We also observed that the epidermis became disorganised and frequently separated from the underlying mesoderm, causing the formation of epidermal blisters. Together, our results suggest that loss of kazrinA causes defects in cell adhesion that affect axial elongation, cell differentiation, and epidermal morphogenesis. 相似文献
994.
995.
996.
A Arora R K Tandon P Jain R R Singh A N Malaviya S Mukherjee J Agarwal V S Rana 《Tropical gastroenterology》1989,10(1):56-61
This reports a 27 yr old female Patient with seronegative polyarthritis who presented with lower GI bleeding and subsequently developed evidence of cutaneous vasculitis (palpable purpura) and orogenital ulcers. The cause of the GI bleeding was multiple ulcerations in the terminal ileum, cecum ascending colon and transverse colon. Continued and massive bleeding necessitated surgical resection of the involved segment of gut which on histopathological examination confirmed the presence of vasculities. This patient was thus diagnosed as having Behcet's disease. Although major GI bleeding is a rare manifestation of Behcet's disease with vasculitis of the gut, one must consider this possibility if the patient has multi-system involvement with evidence of vasculitis involving the skin in the form of palpable purpura. 相似文献
997.
Laparoscopic appendectomy in a female patient with situs inversus: case report and literature review. 总被引:1,自引:0,他引:1
Jonathan Y Song Nasir Rana Carlos A Rotman 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2004,8(2):175-177
BACKGROUND: Situs inversus is an uncommon condition caused by a single autosomal recessive gene of incomplete penetration. A potential diagnostic dilemma can occur in the young female patient with a history of situs inversus who presents with pelvic pain. METHODS: A 32-year-old multiparous patient with a known history of situs inversus presented with complaints of pelvic pain. A medical history and full physical examination were indicative of possible endometriosis. RESULTS: The patient underwent an operative laparoscopy, which revealed stage II pelvic endometriosis based on the American Fertility Society Revised Classification for Endometriosis (R-AFS), with appendicular and periappendicular adhesions involving the cecum. Ablation of endometriosis and an appendectomy were performed. CONCLUSION: The authors believe the laparoscopic approach to an appendectomy is ideal in a patient with situs inversus and should be performed at the time of laparoscopy performed for another reason. 相似文献
998.
999.
In early life, patients with sickle cell disease (SCD) can have acute, life-threatening emergencies related to splenic hypofunction
(overwhelming bacterial sepsis), as well as anemic crises from acute splenic sequestration because of sudden pooling of blood
in the spleen. The landmark penicillin prophylaxis study in 1985 showed a remarkable decrease in mortality from sepsis in
young children with SCD who were treated with oral penicillin prophylaxis compared to placebo. Since that study, newborns
are screened for SCD and placed on oral penicillin prophylaxis in nearly all of the United States, as well as in other countries
where the disease is highly prevalent. The previously described permanent, complete and nearly universal “autosplenectomy”
emerging by late childhood or early adulthood is now challenged by recent findings of reversibility of splenic dysfunction
by the antisickling drug hydroxyurea or by successful allogeneic stem cell transplantation, even in older patients. Imaging
techniques for hypofunction of the spleen are the most commonly used modalities to guide the clinician in decisions regarding
medical or surgical management. 相似文献
1000.
Laura Washburn Nhu Thao Nguyen Galván Priyanka Moolchandani Matthew B. Price Smruti Rath Ruth Ackah Kevin A. Myers R. P. Wood Sandra Parsons Ryan P. Brown Elitza Ranova Matthew Goss Abbas Rana John A. Goss 《American journal of transplantation》2021,21(1):114-122
Imminent death donation (IDD) is described as living organ donation prior to a planned withdrawal of life-sustaining care in an imminently dying patient. Although IDD was ethically justified by United Network for Organ Sharing, the concept remains controversial due to presumed lack of public support. The aim of this study was to evaluate the public's attitudes towards IDD. A cross-sectional survey was conducted of US adults age >18 years (n = 2644). The survey included a case scenario of a patient with a devastating brain injury. Responses were assessed on a 5-point Likert scale. Results showed that 68% - 74% of participants agreed or strongly agreed with IDD when posed as a general question and in relation to the case scenario. Participants were concerned about “recovery after a devastating brain injury” (34%), and that “doctors would not try as hard to save a patient's life” (33%). Only 9% of participants would be less likely to trust the organ donation process. In conclusion, our study demonstrates strong public support for IDD in the case of a patient with a devastating brain injury. Notably, participants were not largely concerned with losing trust in the organ donation process. These results justify policy change towards imminent death donation. 相似文献