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排序方式: 共有490条查询结果,搜索用时 25 毫秒
441.
M Smelt 《Nursing times》1975,71(33):1308-1309
442.
The association between histo-compatibility antigens and disease is reviewed, in particular that between HLA-B27 and spondylitic disorders, i.e., ankylosing spondylitis, Reiter's arthritis, psoriatic arthritis, and ankylosing hyperostosis. We determined whether the presence of HLA-B27 predicted specific radiographic findings and, conversely, whether specific radiographic changes predicted antigenic status. The prevalences of the HLA-B27 antigen in our patients were: ankylosing spondylitis, 100%; Reiter's arthritis, 93%; psoriatic arthritis, 55%; and ankylosing hyperostosis, 12%. The only specific radiographic finding associated with B27 positivity was severe spondylitis in psoriasis. 相似文献
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446.
It is more than a century since tympanic epithelial dispersion was first noted. This concept has not been analyzed mechanically until now. Serial photography of a circular disc holding 530 2.5 mm diameter ball-bearings, some of which were painted black to represent ink dots, has shown the centrifugal movement, enlargement and fragmentation of these marked areas when ball-bearings are added at random into the monolayer. Ink dots applied to mammalian drumheads move in a similar fashion. The model not only represented all the known tympanic epithelial phenomena faithfully, but could also be used to predict a mitotic index for the human drum. The index derived is consistent with normal human forearm skin if the dispersion of the corneocytes is due to the final shape change and insertion of lower epithelial cells into the lowest corneocyte layer. 相似文献
447.
448.
Liu YM; Shiau CY; Wong TT; Wang LW; Wu LJ; Chi KH; Chen KY; Yen SH 《Japanese journal of clinical oncology》1998,28(8):474-479
BACKGROUND: A retrospective analysis was made to clarify the relationship
between prognosis, radiation dose and survival of brain stem gliomas.
METHODS: From 1983 to 1995, 22 children with brain stem tumors were treated
by radiotherapy in the Veterans General Hospital-Taipei. Twelve patients
had pathology proof and the remainder were diagnosed by computerized
tomography and/or magnetic resonance imaging. Seven patients had
postoperative radiotherapy. Fifteen patients had radiotherapy as primary
management, five of whom had adjuvant chemotherapy. All patients received
4000-7060 cGy, either in conventional daily or hyperfractionated twice
daily radiotherapy. Survival from date of diagnosis was calculated by the
Kaplan-Meier method. Univariate analyses and multivariate analyses were
calculated by the log rank test and the Cox proportional hazard model,
respectively. RESULTS: Most patients showed improvement following
treatment. The overall 2-year survival rate was 55.5% with a median
survival of 27.1 months. Two-year survival for patients with primary
management of operation and radiotherapy (n = 7), radiotherapy alone (n =
10) and radiotherapy with adjuvant chemotherapy (n = 5) were 66.7, 50 and
53.3%, respectively. In univariate analysis, the study revealed that the
growth pattern of tumors and the simultaneous presence of cranial
neuropathy and long tract sign were significant prognostic factors (P =
0.017 and 0.036). A trend of better outcome with radiation dose > 6600
cGy and the hyperfractionation scheme was also noted in our study (P =
0.0573 and 0.0615). However, only the hyperfractionation scheme was also
noted in our study (P = 0.0573 and 0.0615). However, only the
hyperfractionation scheme showed significance in multivariate analyses (P =
0.0355). Survival was not significantly affected by age, gender or method
of diagnosis. CONCLUSION: Radiotherapy appears to be an effective treatment
modality of brain stem tumors. Patients with both cranial neuropathy and
long tract signs had a poorer outcome. Hyperfractionated radiotherapy may
give better local control and lead to better survival.
相似文献
449.
AO Grange M Santosham AK Ayodele FEA Lesi RY Stallings KH Brown 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(8):825-832
A randomized clinical trial was carried out to compare a locally available maize-cowpea-palm oil diet (group MCP) with a commercially produced lactose-free, soy protein isolate formula (group SF) for the dietary management of 69 Nigerian boys, 6–24 months of age, hospitalized for acute, watery diarrhea. Although the treatment groups were generally similar initially, the children in group SF had slightly lower mean weight-for-age z scores ( p = O.OS), lower serum bicarbonate levels ( p = 0.04) and greater stool outputs during the period of rehydration before the diets were initiated ( p = 0.01). Rates of treatment failure in group MCP (5.7%) and group SF (8.8%) were similar ( p = 0.67). There were no significant differences in the adjusted mean stool outputs by study group on days 1–5, but the children in group SF had slightly lower fecal weights on day 6 ( p = 0.05). Children in group MCP had a substantially reduced duration of liquid stool excretion (estimated median duration 42 h versus 140 h; p < 0.001). On the other hand, children in group SF consumed considerably more of their diet, had greater net absorption of macronutrients and greater rates of weight gain than those in group MCP. We conclude that children can safely consume the MCP diet during acute, watery diarrhea without increasing their risk of treatment failure or augmenting stool output. However, the diet may not be adequate as a sole source of nutrients beyond the period of acute illness. 相似文献
450.
Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase 总被引:4,自引:2,他引:4
Koshy B; Matilla T; Burright EN; Merry DE; Fischbeck KH; Orr HT; Zoghbi HY 《Human molecular genetics》1996,5(9):1311-1318
Spinocerebellar ataxia type1 (SCA1) is one of several neurodegenerative
disorders caused by expansions of translated CAG trinucleotide repeats
which code for polyglutamine in the respective proteins. Most hypotheses
about the molecular defect in these disorders suggest a gain of function,
which may involve interactions with other proteins via the expanded
polyglutamine tract. In this study we used ataxin-1, the SCA1 gene product,
as a bait in the yeast two-hybrid system and identified the glycolytic
enzyme glyceraldehyde-3-phosphate dehydrogenase as an ataxin-1 interacting
protein. In addition, the yeast two hybrid data demonstrate that wild type
and mutant ataxin-1 form homo and heterodimers. Physical interaction
between GAPDH and ataxin-1 was also demonstrated in vitro. To investigate
if GAPDH might interact with other glutamine repeat-containing proteins
involved in neurodegenerative disorders, we tested its binding to the
androgen receptor which is mutated in spinobulbar muscular atrophy. The
androgen receptor interacts with GAPDH both in the yeast two-hybrid system
and in vitro. The binding of both ataxin-1 and the androgen receptor to
GAPDH does not vary with the length of the polyglutamine tract. While
provocative, these findings do not address the selective neuronal loss in
each of these disorders in light of the wide expression patterns of GAPDH
and the respective polyglutamine containing proteins. Nonetheless, such
interactions may increase the susceptibility of specific neurons to a
variety of insults and initiate degeneration.
相似文献