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71.
72.
Ozsahin H Cavazzana-Calvo M Notarangelo LD Schulz A Thrasher AJ Mazzolari E Slatter MA Le Deist F Blanche S Veys P Fasth A Bredius R Sedlacek P Wulffraat N Ortega J Heilmann C O'Meara A Wachowiak J Kalwak K Matthes-Martin S Gungor T Ikinciogullari A Landais P Cant AJ Friedrich W Fischer A 《Blood》2008,111(1):439-445
Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency with microthrombocytopenia, eczema, recurrent infections, autoimmune disorders, and malignancies that are life-threatening in the majority of patients. In this long-term, retrospective, multicenter study, we analyzed events that occurred in 96 WAS patients who received transplants between 1979 and 2001 who survived at least 2 years following hematopoietic stem-cell transplantation (HSCT). Events included chronic graft-versus-host disease (cGVHD), autoimmunity, infections, and sequelae of before or after HSCT complications. Three patients (3%) died 2.1 to 21 years following HSCT. Overall 7-year event-free survival rate was 75%. It was lower in recipients of mismatched related donors, also in relation with an older age at HSCT and disease severity. The most striking finding was the observation of cGVHD-independent autoimmunity in 20% of patients strongly associated with a mixed/split chimerism status (P < .001), suggesting that residual-host lymphocytes can mediate autoimmune disease despite the coexistence of donor lymphocytes. Infectious complications (6%) related to splenectomy were also significant and may warrant a more restrictive approach to performing splenectomy in WAS patients. Overall, this study provides the basis for a prospective, standardized, and more in-depth detailed analysis of chimerism and events in long-term follow-up of WAS patients who receive transplants to design better-adapted therapeutic strategies. 相似文献
73.
Emily Staples Beatriz Morillo-Gutierrez Jessica Davies Daniel Petersheim Michel Massaad Mary Slatter Dimitra Dimou Rainer Doffinger Scott Hackett Dinkantha Kumararatne James Hadfield Matthew D. Eldridge Raif S. Geha Mario Abinun James E. D. Thaventhiran 《Journal of clinical immunology》2017,37(5):415-418
74.
Sexually transmitted infections (STIs) in young people are increasing, with children aged less than 16 years being particularly vulnerable. We compared the demographic details, spectrum of infection, contraceptive practice and source of referral in patients aged less than 16 years attending 2 genitourinary clinics, one in Swansea and the other in London. In the London population, children aged less than 16 years represented 0.7% of the total new attendances compared with 1.4% in Swansea. The female to male ratio was almost 4:1 in both clinics with most infections confined to female attenders. In females the incidence of chlamydial infection, genital warts and anaerobic (bacterial) vaginosis was 5.5%, 19% and 8%, respectively in London compared with 27%, 32% and 36% in Swansea. Seventy-two per cent of patients attending the clinic in London were self referred compared with 40% in Swansea. Contraceptive practice was also markedly different in the 2 populations, and over one-third of children in both clinics used no contraception. The high incidence of STIs in both populations and low use of contraception has serious implications for the sexual health of young people and emphasizes the need for effective sexual health education at an early age. 相似文献
75.
Shiraki Mayuka Williams Eleri Yokoyama Norifumi Shinoda Kunihiro Nademi Zohreh Matsumoto Kana Nihira Hiroshi Honda Yoshitaka Izawa Kazushi Nishikomori Ryuta Slatter Mary A. Cant Andrew J. Gennery Andrew R. Ohnishi Hidenori Kanegane Hirokazu 《Journal of clinical immunology》2021,41(8):1954-1956
Journal of Clinical Immunology - 相似文献
76.
77.
Amel Hassan Pamela Lee Paraskevi Maggina Jin Hua Xu Diana Moreira Mary Slatter Zohreh Nademi Austen Worth Stuart Adams Alison Jones Catherine Cale Zoe Allwood Kanchan Rao Robert Chiesa Persis Amrolia Hubert Gaspar E. Graham Davies Paul Veys Andrew Gennery Waseem Qasim 《The Journal of allergy and clinical immunology》2014
78.
Christopher C. Dvorak Amel Hassan Mary A. Slatter Manfred Hönig Arjan C. Lankester Rebecca H. Buckley Michael A. Pulsipher Jeffrey H. Davis Tayfun Güngör Melissa Gabriel Jacob H. Bleesing Nancy Bunin Petr Sedlacek James A. Connelly David F. Crawford Luigi D. Notarangelo Sung-Yun Pai Jake Hassid Paul Veys Andrew R. Gennery Morton J. Cowan 《The Journal of allergy and clinical immunology》2014
79.
Carruthers Vicky-Anne Lum Su Han Flood Terence Slatter Mary A. Gennery Andrew R. 《Journal of clinical immunology》2022,42(3):703-705
Journal of Clinical Immunology - 相似文献
80.